Impact of exogenous insulinlike growth factor 1 on hepatic energy metabolism in burn injury

Y. L. Dong, K. F. Huang, Z. F. Xia, D. H. Chung, T. Z. Yan, David Herndon, J. P. Waymack

Research output: Contribution to journalArticle

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Abstract

Background: Insulinlike growth factor 1 (IGF-1) has previously been demonstrated to improve the nutritional status of burned animals. The method by which it achieves this result has not yet been fully elucidated, but may be the result of alterations in hepatic metabolism. Objective: To determine if IGF-1 is able to correct the burn-induced impairments in hepatic metabolic function. Design: Seventy-two Sprague-Dawley rats were subjected to a sham burn (n=24), or a 50% total body surface area scald burn (n=48). Half the scald burn group received 3 μg/kg per day of IGF-1. The remainder received a placebo. The rats were sequentially assayed for multiple components of hepatic function. Results: Insulinlike growth factor 1 corrected the burn- induced decrease in hepatic adenosine triphosphate concentration and prevented the burn-induced increase in hepatic ketone body levels. Insulinlike growth factor 1 was also able to prevent the burn-induced decrease in the hepatic acetoacetate-β hydroxybutyrate ratio. Since this ratio is directly proportional to mitochondrial redox potential this indicates that IGF-1 is also able to prevent the burn-induced impairment in hepatic redox potential. Conclusions: These data indicate that part of the previously demonstrated beneficial effect of IGF-1 in burn injury may be due to its ability to improve multiple components of hepatic metabolism.

Original languageEnglish (US)
Pages (from-to)703-708
Number of pages6
JournalArchives of Surgery
Volume128
Issue number6
StatePublished - 1993

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Energy Metabolism
Intercellular Signaling Peptides and Proteins
Burns
Liver
Wounds and Injuries
Oxidation-Reduction
Hydroxybutyrates
Ketone Bodies
Body Surface Area
Nutritional Status
Sprague Dawley Rats
Adenosine Triphosphate
Placebos

ASJC Scopus subject areas

  • Surgery

Cite this

Dong, Y. L., Huang, K. F., Xia, Z. F., Chung, D. H., Yan, T. Z., Herndon, D., & Waymack, J. P. (1993). Impact of exogenous insulinlike growth factor 1 on hepatic energy metabolism in burn injury. Archives of Surgery, 128(6), 703-708.

Impact of exogenous insulinlike growth factor 1 on hepatic energy metabolism in burn injury. / Dong, Y. L.; Huang, K. F.; Xia, Z. F.; Chung, D. H.; Yan, T. Z.; Herndon, David; Waymack, J. P.

In: Archives of Surgery, Vol. 128, No. 6, 1993, p. 703-708.

Research output: Contribution to journalArticle

Dong, YL, Huang, KF, Xia, ZF, Chung, DH, Yan, TZ, Herndon, D & Waymack, JP 1993, 'Impact of exogenous insulinlike growth factor 1 on hepatic energy metabolism in burn injury', Archives of Surgery, vol. 128, no. 6, pp. 703-708.
Dong YL, Huang KF, Xia ZF, Chung DH, Yan TZ, Herndon D et al. Impact of exogenous insulinlike growth factor 1 on hepatic energy metabolism in burn injury. Archives of Surgery. 1993;128(6):703-708.
Dong, Y. L. ; Huang, K. F. ; Xia, Z. F. ; Chung, D. H. ; Yan, T. Z. ; Herndon, David ; Waymack, J. P. / Impact of exogenous insulinlike growth factor 1 on hepatic energy metabolism in burn injury. In: Archives of Surgery. 1993 ; Vol. 128, No. 6. pp. 703-708.
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