Impact of hepatitis C virus infection on the course and outcome of patients with acute alcoholic hepatitis

Ashwani Kumar Singal, Sashidhar Sagi, Yong Fang Kuo, Steven Weinman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

BACKGROUND AND AIMS: Limited information is available on the impact of hepatitis C virus (HCV) infection on the clinical course and outcome of acute alcoholic hepatitis (AH), a condition with a significant mortality. We designed this retrospective study to assess effect of HCV on the outcome of patients with AH. METHODS: Medical charts of patients with a discharge diagnosis of AH (defined using rigorous clinical criteria) were reviewed. Patients were stratified based on the presence or absence of concomitant HCV infection. The disease severity was estimated at admission and at day 7 using model for end-stage disease and discriminant function index scores. Patient survival at 6 months was confirmed with the county death registry. RESULTS : A total of 76 (29 HCV positive) AH cases were analyzed. At admission, disease severity was similar in both groups with severe disease in 53% (49% of AH alone and 59% of AH+HCV; P=0.18). Although severity scores at day 7 were not available for all patients, disease severity tended to be worse for patients with AH+HCV. Kaplan-Meier survival curves showed a poor survival for AH+HCV compared with AH alone (69 vs. 91%; log-rank P=0.015). Although patients with AH+HCV were treated less often compared with AH alone (27 vs. 54%; P=0.05), HCV emerged as an independent risk factor for a poor outcome at 6 months (Cox proportional hazard ratio 8.45; P=0.01) after controlling for patient demographics, disease severity at admission, and treatment. CONCLUSION: HCV may be a risk factor for patients with AH with a worse outcome at 6 months. If our findings are confirmed in larger databases, prospective studies are needed to examine mechanisms for this effect of HCV on the outcome of AH.

Original languageEnglish (US)
Pages (from-to)204-209
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Volume23
Issue number3
DOIs
StatePublished - Mar 2011

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Alcoholic Hepatitis
Virus Diseases
Hepacivirus
Survival
Kaplan-Meier Estimate

Keywords

  • alcoholic hepatitis
  • alcoholic liver disease
  • hepatitis C virus

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Impact of hepatitis C virus infection on the course and outcome of patients with acute alcoholic hepatitis. / Singal, Ashwani Kumar; Sagi, Sashidhar; Kuo, Yong Fang; Weinman, Steven.

In: European Journal of Gastroenterology and Hepatology, Vol. 23, No. 3, 03.2011, p. 204-209.

Research output: Contribution to journalArticle

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abstract = "BACKGROUND AND AIMS: Limited information is available on the impact of hepatitis C virus (HCV) infection on the clinical course and outcome of acute alcoholic hepatitis (AH), a condition with a significant mortality. We designed this retrospective study to assess effect of HCV on the outcome of patients with AH. METHODS: Medical charts of patients with a discharge diagnosis of AH (defined using rigorous clinical criteria) were reviewed. Patients were stratified based on the presence or absence of concomitant HCV infection. The disease severity was estimated at admission and at day 7 using model for end-stage disease and discriminant function index scores. Patient survival at 6 months was confirmed with the county death registry. RESULTS : A total of 76 (29 HCV positive) AH cases were analyzed. At admission, disease severity was similar in both groups with severe disease in 53{\%} (49{\%} of AH alone and 59{\%} of AH+HCV; P=0.18). Although severity scores at day 7 were not available for all patients, disease severity tended to be worse for patients with AH+HCV. Kaplan-Meier survival curves showed a poor survival for AH+HCV compared with AH alone (69 vs. 91{\%}; log-rank P=0.015). Although patients with AH+HCV were treated less often compared with AH alone (27 vs. 54{\%}; P=0.05), HCV emerged as an independent risk factor for a poor outcome at 6 months (Cox proportional hazard ratio 8.45; P=0.01) after controlling for patient demographics, disease severity at admission, and treatment. CONCLUSION: HCV may be a risk factor for patients with AH with a worse outcome at 6 months. If our findings are confirmed in larger databases, prospective studies are needed to examine mechanisms for this effect of HCV on the outcome of AH.",
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