Impact of maternal age on obstetric outcome

Jane Cleary-Goldman, Fergal D. Malone, John Vidaver, Robert H. Ball, David A. Nyberg, Christine H. Comstock, George Saade, Keith A. Eddleman, Susan Klugman, Lorraine Bugoff, Ilan E. Timor-Tritsch, Sabrina D. Craigo, Stephen R. Carr, Honor M. Wolfe, Diana W. Bianchi, Mary D'Alton

Research output: Contribution to journalArticle

449 Citations (Scopus)

Abstract

OBJECTIVE: To estimate the effect of maternal age on obstetric outcomes. METHODS: A prospective database from a multicenter investigation of singletons, the FASTER trial, was studied. Subjects were divided into 3 age groups: 1) less than 35 years, 2) 35-39 years, and 3) 40 years and older. Multivariable logistic regression analysis was used to assess the effect of age on outcomes after adjusting for race, parity, body mass index, education, marital status, smoking, medical history, use of assisted conception, and patient's study site. RESULTS: A total of 36,056 women with complete data were available: 28,398 (79%) less than 35 years of age; 6,294 (17%) 35-39 years; and 1,364 (4%) 40 years and older. Increasing age was significantly associated with miscarriage (adjusted odds ratio [adjOR]2.0 and 2.4 for ages 35-39 years and age 40 years and older, respectively), chromosomal abnormalities (adjOR 4.0 and 9.9), congenital anomalies (adjOR 1.4 and 1.7), gestational diabetes (adjOR 1.8 and 2.4), placenta previa (adjOR 1.8 and 2.8), and cesarean delivery (adjOR 1.6 and 2.0). Patients aged 35-39 years were at increased risk for macrosomia (adjOR 1.4). Increased risk for abruption (adjOR 2.3), preterm delivery (adjOR 1.4), low birth weight (adjOR 1.6), and perinatal mortality (adjOR 2.2) was noted in women aged 40 years and older. CONCLUSION: Increasing maternal age is independently associated with specific adverse pregnancy outcomes. Increasing age is a continuum rather than a threshold effect.

Original languageEnglish (US)
Pages (from-to)983-990
Number of pages8
JournalObstetrics and Gynecology
Volume105
Issue number5 I
DOIs
StatePublished - May 2005
Externally publishedYes

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Maternal Age
Obstetrics
Odds Ratio
Placenta Previa
Gestational Diabetes
Perinatal Mortality
Marital Status
Low Birth Weight Infant
Spontaneous Abortion
Pregnancy Outcome
Parity
Chromosome Aberrations
Body Mass Index
Age Groups
Logistic Models
Smoking
Regression Analysis
Databases
Education

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Cleary-Goldman, J., Malone, F. D., Vidaver, J., Ball, R. H., Nyberg, D. A., Comstock, C. H., ... D'Alton, M. (2005). Impact of maternal age on obstetric outcome. Obstetrics and Gynecology, 105(5 I), 983-990. https://doi.org/10.1097/01.AOG.0000158118.75532.51

Impact of maternal age on obstetric outcome. / Cleary-Goldman, Jane; Malone, Fergal D.; Vidaver, John; Ball, Robert H.; Nyberg, David A.; Comstock, Christine H.; Saade, George; Eddleman, Keith A.; Klugman, Susan; Bugoff, Lorraine; Timor-Tritsch, Ilan E.; Craigo, Sabrina D.; Carr, Stephen R.; Wolfe, Honor M.; Bianchi, Diana W.; D'Alton, Mary.

In: Obstetrics and Gynecology, Vol. 105, No. 5 I, 05.2005, p. 983-990.

Research output: Contribution to journalArticle

Cleary-Goldman, J, Malone, FD, Vidaver, J, Ball, RH, Nyberg, DA, Comstock, CH, Saade, G, Eddleman, KA, Klugman, S, Bugoff, L, Timor-Tritsch, IE, Craigo, SD, Carr, SR, Wolfe, HM, Bianchi, DW & D'Alton, M 2005, 'Impact of maternal age on obstetric outcome', Obstetrics and Gynecology, vol. 105, no. 5 I, pp. 983-990. https://doi.org/10.1097/01.AOG.0000158118.75532.51
Cleary-Goldman J, Malone FD, Vidaver J, Ball RH, Nyberg DA, Comstock CH et al. Impact of maternal age on obstetric outcome. Obstetrics and Gynecology. 2005 May;105(5 I):983-990. https://doi.org/10.1097/01.AOG.0000158118.75532.51
Cleary-Goldman, Jane ; Malone, Fergal D. ; Vidaver, John ; Ball, Robert H. ; Nyberg, David A. ; Comstock, Christine H. ; Saade, George ; Eddleman, Keith A. ; Klugman, Susan ; Bugoff, Lorraine ; Timor-Tritsch, Ilan E. ; Craigo, Sabrina D. ; Carr, Stephen R. ; Wolfe, Honor M. ; Bianchi, Diana W. ; D'Alton, Mary. / Impact of maternal age on obstetric outcome. In: Obstetrics and Gynecology. 2005 ; Vol. 105, No. 5 I. pp. 983-990.
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T1 - Impact of maternal age on obstetric outcome

AU - Cleary-Goldman, Jane

AU - Malone, Fergal D.

AU - Vidaver, John

AU - Ball, Robert H.

AU - Nyberg, David A.

AU - Comstock, Christine H.

AU - Saade, George

AU - Eddleman, Keith A.

AU - Klugman, Susan

AU - Bugoff, Lorraine

AU - Timor-Tritsch, Ilan E.

AU - Craigo, Sabrina D.

AU - Carr, Stephen R.

AU - Wolfe, Honor M.

AU - Bianchi, Diana W.

AU - D'Alton, Mary

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N2 - OBJECTIVE: To estimate the effect of maternal age on obstetric outcomes. METHODS: A prospective database from a multicenter investigation of singletons, the FASTER trial, was studied. Subjects were divided into 3 age groups: 1) less than 35 years, 2) 35-39 years, and 3) 40 years and older. Multivariable logistic regression analysis was used to assess the effect of age on outcomes after adjusting for race, parity, body mass index, education, marital status, smoking, medical history, use of assisted conception, and patient's study site. RESULTS: A total of 36,056 women with complete data were available: 28,398 (79%) less than 35 years of age; 6,294 (17%) 35-39 years; and 1,364 (4%) 40 years and older. Increasing age was significantly associated with miscarriage (adjusted odds ratio [adjOR]2.0 and 2.4 for ages 35-39 years and age 40 years and older, respectively), chromosomal abnormalities (adjOR 4.0 and 9.9), congenital anomalies (adjOR 1.4 and 1.7), gestational diabetes (adjOR 1.8 and 2.4), placenta previa (adjOR 1.8 and 2.8), and cesarean delivery (adjOR 1.6 and 2.0). Patients aged 35-39 years were at increased risk for macrosomia (adjOR 1.4). Increased risk for abruption (adjOR 2.3), preterm delivery (adjOR 1.4), low birth weight (adjOR 1.6), and perinatal mortality (adjOR 2.2) was noted in women aged 40 years and older. CONCLUSION: Increasing maternal age is independently associated with specific adverse pregnancy outcomes. Increasing age is a continuum rather than a threshold effect.

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