Impact of oxandrolone treatment on acute outcomes after severe burn injury

Tam N. Pham, Matthew B. Klein, Nicole S. Gibran, Brett D. Arnoldo, Richard L. Gamelli, Geoffrey M. Silver, Marc G. Jeschke, Celeste Finnerty, Ronald G. Tompkins, David Herndon

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Pharmacologic modulation of hypermetabolism clearly benefits children with major burns, however, its role in adult burns remains to be defined. Oxandrolone appears to be a promising anabolic agent although few outcome data are as yet available. We examined whether early oxandrolone treatment in severely burned adults was associated with improved outcomes during acute hospitalization. We evaluated for potential associations between oxandrolone treatment and outcomes in a large cohort of severely burned adults in the context of a multicenter observational study. Patients were dichotomized with respect to oxandrolone treatment, defined as administration within 7 days after admission, with duration of at least 7 days. Acute hospitalization outcomes were compared with univariate and multivariate analyses. One hundred seventeen patients were included in this analysis. Mean patient age was 42.6 years (range, 18-86); 77% were male, with an average TBSA of 44.1%. Baseline and injury characteristics were similar among treatment and nontreatment cohorts. Oxandrolone treatment (N = 59) did not impact length of stay but was associated with a lower mortality rate (P = .01) by univariate analysis. Oxandrolone treatment was independently associated with higher survival by adjusted analyses (P = .02). Examination of early oxandrolone treatment in this cohort of severely burned adults suggests that this therapy is safe and may be associated with improved survival. Further studies are necessary to define the exact mechanisms by which oxandrolone is beneficial during inpatient treatment. (J Burn Care Res 2008;29:902-906)

Original languageEnglish (US)
Pages (from-to)902-906
Number of pages5
JournalJournal of Burn Care and Research
Volume29
Issue number6
DOIs
StatePublished - Nov 2008

Fingerprint

Oxandrolone
Wounds and Injuries
Therapeutics
Burns
Hospitalization
Anabolic Agents
Survival Analysis
Multicenter Studies
Observational Studies
Inpatients
Length of Stay
Multivariate Analysis

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery

Cite this

Pham, T. N., Klein, M. B., Gibran, N. S., Arnoldo, B. D., Gamelli, R. L., Silver, G. M., ... Herndon, D. (2008). Impact of oxandrolone treatment on acute outcomes after severe burn injury. Journal of Burn Care and Research, 29(6), 902-906. https://doi.org/10.1097/BCR.0b013e31818bal4d

Impact of oxandrolone treatment on acute outcomes after severe burn injury. / Pham, Tam N.; Klein, Matthew B.; Gibran, Nicole S.; Arnoldo, Brett D.; Gamelli, Richard L.; Silver, Geoffrey M.; Jeschke, Marc G.; Finnerty, Celeste; Tompkins, Ronald G.; Herndon, David.

In: Journal of Burn Care and Research, Vol. 29, No. 6, 11.2008, p. 902-906.

Research output: Contribution to journalArticle

Pham, TN, Klein, MB, Gibran, NS, Arnoldo, BD, Gamelli, RL, Silver, GM, Jeschke, MG, Finnerty, C, Tompkins, RG & Herndon, D 2008, 'Impact of oxandrolone treatment on acute outcomes after severe burn injury', Journal of Burn Care and Research, vol. 29, no. 6, pp. 902-906. https://doi.org/10.1097/BCR.0b013e31818bal4d
Pham, Tam N. ; Klein, Matthew B. ; Gibran, Nicole S. ; Arnoldo, Brett D. ; Gamelli, Richard L. ; Silver, Geoffrey M. ; Jeschke, Marc G. ; Finnerty, Celeste ; Tompkins, Ronald G. ; Herndon, David. / Impact of oxandrolone treatment on acute outcomes after severe burn injury. In: Journal of Burn Care and Research. 2008 ; Vol. 29, No. 6. pp. 902-906.
@article{b3035f2678b64838b0b2872a64e24f94,
title = "Impact of oxandrolone treatment on acute outcomes after severe burn injury",
abstract = "Pharmacologic modulation of hypermetabolism clearly benefits children with major burns, however, its role in adult burns remains to be defined. Oxandrolone appears to be a promising anabolic agent although few outcome data are as yet available. We examined whether early oxandrolone treatment in severely burned adults was associated with improved outcomes during acute hospitalization. We evaluated for potential associations between oxandrolone treatment and outcomes in a large cohort of severely burned adults in the context of a multicenter observational study. Patients were dichotomized with respect to oxandrolone treatment, defined as administration within 7 days after admission, with duration of at least 7 days. Acute hospitalization outcomes were compared with univariate and multivariate analyses. One hundred seventeen patients were included in this analysis. Mean patient age was 42.6 years (range, 18-86); 77{\%} were male, with an average TBSA of 44.1{\%}. Baseline and injury characteristics were similar among treatment and nontreatment cohorts. Oxandrolone treatment (N = 59) did not impact length of stay but was associated with a lower mortality rate (P = .01) by univariate analysis. Oxandrolone treatment was independently associated with higher survival by adjusted analyses (P = .02). Examination of early oxandrolone treatment in this cohort of severely burned adults suggests that this therapy is safe and may be associated with improved survival. Further studies are necessary to define the exact mechanisms by which oxandrolone is beneficial during inpatient treatment. (J Burn Care Res 2008;29:902-906)",
author = "Pham, {Tam N.} and Klein, {Matthew B.} and Gibran, {Nicole S.} and Arnoldo, {Brett D.} and Gamelli, {Richard L.} and Silver, {Geoffrey M.} and Jeschke, {Marc G.} and Celeste Finnerty and Tompkins, {Ronald G.} and David Herndon",
year = "2008",
month = "11",
doi = "10.1097/BCR.0b013e31818bal4d",
language = "English (US)",
volume = "29",
pages = "902--906",
journal = "Journal of Burn Care and Research",
issn = "1559-047X",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Impact of oxandrolone treatment on acute outcomes after severe burn injury

AU - Pham, Tam N.

AU - Klein, Matthew B.

AU - Gibran, Nicole S.

AU - Arnoldo, Brett D.

AU - Gamelli, Richard L.

AU - Silver, Geoffrey M.

AU - Jeschke, Marc G.

AU - Finnerty, Celeste

AU - Tompkins, Ronald G.

AU - Herndon, David

PY - 2008/11

Y1 - 2008/11

N2 - Pharmacologic modulation of hypermetabolism clearly benefits children with major burns, however, its role in adult burns remains to be defined. Oxandrolone appears to be a promising anabolic agent although few outcome data are as yet available. We examined whether early oxandrolone treatment in severely burned adults was associated with improved outcomes during acute hospitalization. We evaluated for potential associations between oxandrolone treatment and outcomes in a large cohort of severely burned adults in the context of a multicenter observational study. Patients were dichotomized with respect to oxandrolone treatment, defined as administration within 7 days after admission, with duration of at least 7 days. Acute hospitalization outcomes were compared with univariate and multivariate analyses. One hundred seventeen patients were included in this analysis. Mean patient age was 42.6 years (range, 18-86); 77% were male, with an average TBSA of 44.1%. Baseline and injury characteristics were similar among treatment and nontreatment cohorts. Oxandrolone treatment (N = 59) did not impact length of stay but was associated with a lower mortality rate (P = .01) by univariate analysis. Oxandrolone treatment was independently associated with higher survival by adjusted analyses (P = .02). Examination of early oxandrolone treatment in this cohort of severely burned adults suggests that this therapy is safe and may be associated with improved survival. Further studies are necessary to define the exact mechanisms by which oxandrolone is beneficial during inpatient treatment. (J Burn Care Res 2008;29:902-906)

AB - Pharmacologic modulation of hypermetabolism clearly benefits children with major burns, however, its role in adult burns remains to be defined. Oxandrolone appears to be a promising anabolic agent although few outcome data are as yet available. We examined whether early oxandrolone treatment in severely burned adults was associated with improved outcomes during acute hospitalization. We evaluated for potential associations between oxandrolone treatment and outcomes in a large cohort of severely burned adults in the context of a multicenter observational study. Patients were dichotomized with respect to oxandrolone treatment, defined as administration within 7 days after admission, with duration of at least 7 days. Acute hospitalization outcomes were compared with univariate and multivariate analyses. One hundred seventeen patients were included in this analysis. Mean patient age was 42.6 years (range, 18-86); 77% were male, with an average TBSA of 44.1%. Baseline and injury characteristics were similar among treatment and nontreatment cohorts. Oxandrolone treatment (N = 59) did not impact length of stay but was associated with a lower mortality rate (P = .01) by univariate analysis. Oxandrolone treatment was independently associated with higher survival by adjusted analyses (P = .02). Examination of early oxandrolone treatment in this cohort of severely burned adults suggests that this therapy is safe and may be associated with improved survival. Further studies are necessary to define the exact mechanisms by which oxandrolone is beneficial during inpatient treatment. (J Burn Care Res 2008;29:902-906)

UR - http://www.scopus.com/inward/record.url?scp=57149105345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57149105345&partnerID=8YFLogxK

U2 - 10.1097/BCR.0b013e31818bal4d

DO - 10.1097/BCR.0b013e31818bal4d

M3 - Article

C2 - 18849836

AN - SCOPUS:57149105345

VL - 29

SP - 902

EP - 906

JO - Journal of Burn Care and Research

JF - Journal of Burn Care and Research

SN - 1559-047X

IS - 6

ER -