TY - JOUR
T1 - Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
AU - Rodriguez-Barraquer, Isabel
AU - Costa, Federico
AU - Nascimento, Eduardo J.M.
AU - Júnior, Nivison Nery
AU - Castanha, Priscila M.S.
AU - Sacramento, Gielson Almeida
AU - Cruz, Jaqueline
AU - Carvalho, Mayara
AU - De Olivera, Daiana
AU - Hagan, José E.
AU - Adhikarla, Haritha
AU - Wunder, Elsio A.
AU - Coêlho, Danilo F.
AU - Azar, Sasha R.
AU - Rossi, Shannan L.
AU - Vasilakis, Nikos
AU - Weaver, Scott C.
AU - Ribeiro, Guilherme S.
AU - Balmaseda, Angel
AU - Harris, Eva
AU - Nogueira, Maurício L.
AU - Reis, Mitermayer G.
AU - Marques, Ernesto T.A.
AU - Cummings, Derek A.T.
AU - Ko, Albert I.
N1 - Funding Information:
We thank the participants of the cohort study and the community leaders from the Pau da Lima Urban Health Council who mobilized support for the investigation; the team members from Oswaldo Cruz Foundation, Brazilian Ministry of Health, who participated in the data collection; the Company for Urban Development of the State of Bahía (CONDER), which provided digital maps of the study site; G. Kuan and the study team at the National Virology Laboratory, the Sócrates Flores Vivas Health Center, the Hospital Infantil Manuel de Jesús Rivera of the Nicaraguan Ministry of Health, and the Sustainable Sciences Institute for their work in collecting and characterizing the samples from the Nicaraguan Pediatric Dengue Cohort Study and the Pediatric Dengue Hospital-based Study in Managua, Nicaragua, that were used in this study; M. Montoya at the University of California, Berkeley, for assistance with sample management; and the World Reference Collection of Emerging Viruses and Arboviruses (WRCEVA) by the Allergan Foundation and the Global Virus Network for providing sera on U.S. travelers. This work could not be accomplished without the joint collaborative effort of the resident associations, community leaders, and residents that constitute the Urban Health Council of Pau da Lima. Supported by grants from the Yale School of Public Health; Oswaldo Cruz Foundation, Brazilian Ministry of Health; Brazilian National Council for Scientific and Technological Development (400830/2013-2, 440891/ 2016-7, and INCT-Dengue); Coordination for the Improvement of Higher Education Personnel, Brazilian Ministry of Education [440891/2016-7, National Postdoctoral Program (PNPD)]; Research Support Foundation for the State of Bahía (FAPESB PET0026/2013, APP0044/2016, 10206/2015, and PET0022/2016); Research Support Foundation for the State of São Paulo (FAPESP 2013/21719-3 and 2016/15021-1); CuraZika Foundation (curazika. pitt.edu); Wellcome Trust (102330/Z/13/Z); and NIH grants R01 AI121207, R01 TW009504, R01 AI052473, U01 AI088752, R25 TW009338, R01 NS064905, R24 AI120942, U01 AI115577, R01 AI099631, U54 AI065359, P01 AI106695, U19 AI118610, R01 AI114703, and U54 GM088491. S.R.A. was funded in part by the McLaughlin Fellowship Fund.
Publisher Copyright:
© 2017 The Authors.
PY - 2019/2/8
Y1 - 2019/2/8
N2 - The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.
AB - The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.
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U2 - 10.1126/science.aav6618
DO - 10.1126/science.aav6618
M3 - Article
C2 - 30733412
AN - SCOPUS:85061214181
VL - 363
SP - 607
EP - 610
JO - Science
JF - Science
SN - 0036-8075
IS - 6427
ER -