Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region

Isabel Rodriguez-Barraquer, Federico Costa, Eduardo J.M. Nascimento, Nivison Nery Júnior, Priscila M.S. Castanha, Gielson Almeida Sacramento, Jaqueline Cruz, Mayara Carvalho, Daiana De Olivera, José E. Hagan, Haritha Adhikarla, Elsio A. Wunder, Danilo F. Coêlho, Sasha R. Azar, Shannan Rossi, Nikos Vasilakis, Scott Weaver, Guilherme S. Ribeiro, Angel Balmaseda, Eva HarrisMaurício L. Nogueira, Mitermayer G. Reis, Ernesto T.A. Marques, Derek A.T. Cummings, Albert I. Ko

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.

Original languageEnglish (US)
Pages (from-to)607-610
Number of pages4
JournalScience
Volume363
Issue number6427
DOIs
StatePublished - Feb 8 2019

Fingerprint

Dengue
Immunity
Dengue Virus
Pandemics
Disease Outbreaks
Brazil
Immunoglobulins
Antigens
Antibodies
Zika Virus

ASJC Scopus subject areas

  • General

Cite this

Rodriguez-Barraquer, I., Costa, F., Nascimento, E. J. M., Júnior, N. N., Castanha, P. M. S., Sacramento, G. A., ... Ko, A. I. (2019). Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. Science, 363(6427), 607-610. https://doi.org/10.1126/science.aav6618

Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. / Rodriguez-Barraquer, Isabel; Costa, Federico; Nascimento, Eduardo J.M.; Júnior, Nivison Nery; Castanha, Priscila M.S.; Sacramento, Gielson Almeida; Cruz, Jaqueline; Carvalho, Mayara; De Olivera, Daiana; Hagan, José E.; Adhikarla, Haritha; Wunder, Elsio A.; Coêlho, Danilo F.; Azar, Sasha R.; Rossi, Shannan; Vasilakis, Nikos; Weaver, Scott; Ribeiro, Guilherme S.; Balmaseda, Angel; Harris, Eva; Nogueira, Maurício L.; Reis, Mitermayer G.; Marques, Ernesto T.A.; Cummings, Derek A.T.; Ko, Albert I.

In: Science, Vol. 363, No. 6427, 08.02.2019, p. 607-610.

Research output: Contribution to journalArticle

Rodriguez-Barraquer, I, Costa, F, Nascimento, EJM, Júnior, NN, Castanha, PMS, Sacramento, GA, Cruz, J, Carvalho, M, De Olivera, D, Hagan, JE, Adhikarla, H, Wunder, EA, Coêlho, DF, Azar, SR, Rossi, S, Vasilakis, N, Weaver, S, Ribeiro, GS, Balmaseda, A, Harris, E, Nogueira, ML, Reis, MG, Marques, ETA, Cummings, DAT & Ko, AI 2019, 'Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region', Science, vol. 363, no. 6427, pp. 607-610. https://doi.org/10.1126/science.aav6618
Rodriguez-Barraquer I, Costa F, Nascimento EJM, Júnior NN, Castanha PMS, Sacramento GA et al. Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. Science. 2019 Feb 8;363(6427):607-610. https://doi.org/10.1126/science.aav6618
Rodriguez-Barraquer, Isabel ; Costa, Federico ; Nascimento, Eduardo J.M. ; Júnior, Nivison Nery ; Castanha, Priscila M.S. ; Sacramento, Gielson Almeida ; Cruz, Jaqueline ; Carvalho, Mayara ; De Olivera, Daiana ; Hagan, José E. ; Adhikarla, Haritha ; Wunder, Elsio A. ; Coêlho, Danilo F. ; Azar, Sasha R. ; Rossi, Shannan ; Vasilakis, Nikos ; Weaver, Scott ; Ribeiro, Guilherme S. ; Balmaseda, Angel ; Harris, Eva ; Nogueira, Maurício L. ; Reis, Mitermayer G. ; Marques, Ernesto T.A. ; Cummings, Derek A.T. ; Ko, Albert I. / Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. In: Science. 2019 ; Vol. 363, No. 6427. pp. 607-610.
@article{e79c3c681f5a4494b11ff9e97a119d25,
title = "Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region",
abstract = "The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73{\%} of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.",
author = "Isabel Rodriguez-Barraquer and Federico Costa and Nascimento, {Eduardo J.M.} and J{\'u}nior, {Nivison Nery} and Castanha, {Priscila M.S.} and Sacramento, {Gielson Almeida} and Jaqueline Cruz and Mayara Carvalho and {De Olivera}, Daiana and Hagan, {Jos{\'e} E.} and Haritha Adhikarla and Wunder, {Elsio A.} and Co{\^e}lho, {Danilo F.} and Azar, {Sasha R.} and Shannan Rossi and Nikos Vasilakis and Scott Weaver and Ribeiro, {Guilherme S.} and Angel Balmaseda and Eva Harris and Nogueira, {Maur{\'i}cio L.} and Reis, {Mitermayer G.} and Marques, {Ernesto T.A.} and Cummings, {Derek A.T.} and Ko, {Albert I.}",
year = "2019",
month = "2",
day = "8",
doi = "10.1126/science.aav6618",
language = "English (US)",
volume = "363",
pages = "607--610",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6427",

}

TY - JOUR

T1 - Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region

AU - Rodriguez-Barraquer, Isabel

AU - Costa, Federico

AU - Nascimento, Eduardo J.M.

AU - Júnior, Nivison Nery

AU - Castanha, Priscila M.S.

AU - Sacramento, Gielson Almeida

AU - Cruz, Jaqueline

AU - Carvalho, Mayara

AU - De Olivera, Daiana

AU - Hagan, José E.

AU - Adhikarla, Haritha

AU - Wunder, Elsio A.

AU - Coêlho, Danilo F.

AU - Azar, Sasha R.

AU - Rossi, Shannan

AU - Vasilakis, Nikos

AU - Weaver, Scott

AU - Ribeiro, Guilherme S.

AU - Balmaseda, Angel

AU - Harris, Eva

AU - Nogueira, Maurício L.

AU - Reis, Mitermayer G.

AU - Marques, Ernesto T.A.

AU - Cummings, Derek A.T.

AU - Ko, Albert I.

PY - 2019/2/8

Y1 - 2019/2/8

N2 - The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.

AB - The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.

UR - http://www.scopus.com/inward/record.url?scp=85061214181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061214181&partnerID=8YFLogxK

U2 - 10.1126/science.aav6618

DO - 10.1126/science.aav6618

M3 - Article

C2 - 30733412

AN - SCOPUS:85061214181

VL - 363

SP - 607

EP - 610

JO - Science

JF - Science

SN - 0036-8075

IS - 6427

ER -