Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region

Isabel Rodriguez-Barraquer, Federico Costa, Eduardo J.M. Nascimento, Nivison Nery Júnior, Priscila M.S. Castanha, Gielson Almeida Sacramento, Jaqueline Cruz, Mayara Carvalho, Daiana De Olivera, José E. Hagan, Haritha Adhikarla, Elsio A. Wunder, Danilo F. Coêlho, Sasha R. Azar, Shannan L. Rossi, Nikos Vasilakis, Scott C. Weaver, Guilherme S. Ribeiro, Angel Balmaseda, Eva HarrisMaurício L. Nogueira, Mitermayer G. Reis, Ernesto T.A. Marques, Derek A.T. Cummings, Albert I. Ko

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.

Original languageEnglish (US)
Pages (from-to)607-610
Number of pages4
JournalScience
Volume363
Issue number6427
DOIs
StatePublished - Feb 8 2019

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region'. Together they form a unique fingerprint.

Cite this