Abstract
The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 607-610 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 363 |
| Issue number | 6427 |
| DOIs | |
| State | Published - Feb 8 2019 |
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ASJC Scopus subject areas
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Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. / Rodriguez-Barraquer, Isabel; Costa, Federico; Nascimento, Eduardo J.M.; Júnior, Nivison Nery; Castanha, Priscila M.S.; Sacramento, Gielson Almeida; Cruz, Jaqueline; Carvalho, Mayara; De Olivera, Daiana; Hagan, José E.; Adhikarla, Haritha; Wunder, Elsio A.; Coêlho, Danilo F.; Azar, Sasha R.; Rossi, Shannan; Vasilakis, Nikos; Weaver, Scott; Ribeiro, Guilherme S.; Balmaseda, Angel; Harris, Eva; Nogueira, Maurício L.; Reis, Mitermayer G.; Marques, Ernesto T.A.; Cummings, Derek A.T.; Ko, Albert I.
In: Science, Vol. 363, No. 6427, 08.02.2019, p. 607-610.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
AU - Rodriguez-Barraquer, Isabel
AU - Costa, Federico
AU - Nascimento, Eduardo J.M.
AU - Júnior, Nivison Nery
AU - Castanha, Priscila M.S.
AU - Sacramento, Gielson Almeida
AU - Cruz, Jaqueline
AU - Carvalho, Mayara
AU - De Olivera, Daiana
AU - Hagan, José E.
AU - Adhikarla, Haritha
AU - Wunder, Elsio A.
AU - Coêlho, Danilo F.
AU - Azar, Sasha R.
AU - Rossi, Shannan
AU - Vasilakis, Nikos
AU - Weaver, Scott
AU - Ribeiro, Guilherme S.
AU - Balmaseda, Angel
AU - Harris, Eva
AU - Nogueira, Maurício L.
AU - Reis, Mitermayer G.
AU - Marques, Ernesto T.A.
AU - Cummings, Derek A.T.
AU - Ko, Albert I.
PY - 2019/2/8
Y1 - 2019/2/8
N2 - The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.
AB - The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.
UR - http://www.scopus.com/inward/record.url?scp=85061214181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061214181&partnerID=8YFLogxK
U2 - 10.1126/science.aav6618
DO - 10.1126/science.aav6618
M3 - Article
C2 - 30733412
AN - SCOPUS:85061214181
VL - 363
SP - 607
EP - 610
JO - Science
JF - Science
SN - 0036-8075
IS - 6427
ER -