Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region

Isabel Rodriguez-Barraquer; Federico Costa; Eduardo J.M. Nascimento; Nivison Nery Júnior; Priscila M.S. Castanha; Gielson Almeida Sacramento; Jaqueline Cruz; Mayara Carvalho; Daiana De Olivera; José E. Hagan; Haritha Adhikarla; Elsio A. Wunder; Danilo F. Coêlho; Sasha Azar; Shannan L. Rossi; Nikos Vasilakis; Scott C. Weaver; Guilherme S. Ribeiro; Angel Balmaseda; Eva Harris; Maurício L. Nogueira; Mitermayer G. Reis; Ernesto T.A. Marques; Derek A.T. Cummings; Albert I. Ko

doi:10.1126/science.aav6618

Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region

Isabel Rodriguez-Barraquer, Federico Costa, Eduardo J.M. Nascimento, Nivison Nery Júnior, Priscila M.S. Castanha, Gielson Almeida Sacramento, Jaqueline Cruz, Mayara Carvalho, Daiana De Olivera, José E. Hagan, Haritha Adhikarla, Elsio A. Wunder, Danilo F. Coêlho, Sasha Azar, Shannan L. Rossi, Nikos Vasilakis, Scott C. Weaver, Guilherme S. Ribeiro, Angel Balmaseda, Eva HarrisMaurício L. Nogueira, Mitermayer G. Reis, Ernesto T.A. Marques, Derek A.T. Cummings, Albert I. Ko

Pathology

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187 Scopus citations

Abstract

The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.

Original language	English (US)
Pages (from-to)	607-610
Number of pages	4
Journal	Science
Volume	363
Issue number	6427
DOIs	https://doi.org/10.1126/science.aav6618
State	Published - Feb 8 2019

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Rodriguez-Barraquer, I., Costa, F., Nascimento, E. J. M., Júnior, N. N., Castanha, P. M. S., Sacramento, G. A., Cruz, J., Carvalho, M., De Olivera, D., Hagan, J. E., Adhikarla, H., Wunder, E. A., Coêlho, D. F., Azar, S., Rossi, S. L., Vasilakis, N., Weaver, S. C., Ribeiro, G. S., Balmaseda, A., ... Ko, A. I. (2019). Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. Science, 363(6427), 607-610. https://doi.org/10.1126/science.aav6618

Rodriguez-Barraquer, I, Costa, F, Nascimento, EJM, Júnior, NN, Castanha, PMS, Sacramento, GA, Cruz, J, Carvalho, M, De Olivera, D, Hagan, JE, Adhikarla, H, Wunder, EA, Coêlho, DF, Azar, S, Rossi, SL , Vasilakis, N , Weaver, SC, Ribeiro, GS, Balmaseda, A, Harris, E, Nogueira, ML, Reis, MG, Marques, ETA, Cummings, DAT & Ko, AI 2019, 'Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region', Science, vol. 363, no. 6427, pp. 607-610. https://doi.org/10.1126/science.aav6618

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title = "Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region",

abstract = "The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.",

author = "Isabel Rodriguez-Barraquer and Federico Costa and Nascimento, {Eduardo J.M.} and J{\'u}nior, {Nivison Nery} and Castanha, {Priscila M.S.} and Sacramento, {Gielson Almeida} and Jaqueline Cruz and Mayara Carvalho and {De Olivera}, Daiana and Hagan, {Jos{\'e} E.} and Haritha Adhikarla and Wunder, {Elsio A.} and Co{\^e}lho, {Danilo F.} and Sasha Azar and Rossi, {Shannan L.} and Nikos Vasilakis and Weaver, {Scott C.} and Ribeiro, {Guilherme S.} and Angel Balmaseda and Eva Harris and Nogueira, {Maur{\'i}cio L.} and Reis, {Mitermayer G.} and Marques, {Ernesto T.A.} and Cummings, {Derek A.T.} and Ko, {Albert I.}",

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AU - Costa, Federico

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AU - Júnior, Nivison Nery

AU - Castanha, Priscila M.S.

AU - Sacramento, Gielson Almeida

AU - Cruz, Jaqueline

AU - Carvalho, Mayara

AU - De Olivera, Daiana

AU - Hagan, José E.

AU - Adhikarla, Haritha

AU - Wunder, Elsio A.

AU - Coêlho, Danilo F.

AU - Azar, Sasha

AU - Rossi, Shannan L.

AU - Vasilakis, Nikos

AU - Weaver, Scott C.

AU - Ribeiro, Guilherme S.

AU - Balmaseda, Angel

AU - Harris, Eva

AU - Nogueira, Maurício L.

AU - Reis, Mitermayer G.

AU - Marques, Ernesto T.A.

AU - Cummings, Derek A.T.

AU - Ko, Albert I.

PY - 2019/2/8

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Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region

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