Abstract
Objective. The objective of this study was to determine if the continued use of vitamin A in a nursery utilizing early surfactant and nasal continuous positive airway pressure (CPAP) was warranted. Study design.A retrospective, cohort study of appropriately sized, preterm neonates weighing ≤1000g at birth was conducted. Two time periods were compared: Pre-Vitamin A was composed of extremely low birth weight who were routinely cared for with early nasal CPAP (n=76); and Post-Vitamin A (n=102) consisted of ELBWs who were cared for similar to Pre-Vitamin A, but with the addition of vitamin A. Outcome variables included the incidence of BPD and other pulmonary and major neonatal morbidities. Results. Between Pre-Vitamin A and Post-Vitamin A the incidence of moderate to severe BPD decreased by 11%, from 33% to 22% (p=0.2). No difference was found in the number of ventilator days or in the incidence of any other neonatal morbidity or mortality, including intraventricular hemorrhage, necrotizing enterocolitis, or patent ductus arteriosus requiring surgical ligation. Conclusion. In a neonatal unit utilizing early surfactant followed by nasal CPAP at delivery, supplementing extremely premature neonates with vitamin A demonstrated a trend towards a decrease in the incidence of moderate to severe BPD; however, this change requires a larger sample to verify in the future.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 84-88 |
| Number of pages | 5 |
| Journal | Journal of Maternal-Fetal and Neonatal Medicine |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2012 |
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Keywords
- bronchopulmonary disease
- conventional mechanical ventilation
- Nasal continuous positive airway pressure
- neonatal respiratory support
- prematurity
- retinol
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology
Cite this
Impact of providing vitamin A to the routine pulmonary care of extremely low birth weight infants. / Moreira, Alvaro; Caskey, Melinda; Fonseca, Rafael; Malloy, Michael; Geary, Cara.
In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 25, No. 1, 01.2012, p. 84-88.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of providing vitamin A to the routine pulmonary care of extremely low birth weight infants
AU - Moreira, Alvaro
AU - Caskey, Melinda
AU - Fonseca, Rafael
AU - Malloy, Michael
AU - Geary, Cara
PY - 2012/1
Y1 - 2012/1
N2 - Objective. The objective of this study was to determine if the continued use of vitamin A in a nursery utilizing early surfactant and nasal continuous positive airway pressure (CPAP) was warranted. Study design.A retrospective, cohort study of appropriately sized, preterm neonates weighing ≤1000g at birth was conducted. Two time periods were compared: Pre-Vitamin A was composed of extremely low birth weight who were routinely cared for with early nasal CPAP (n=76); and Post-Vitamin A (n=102) consisted of ELBWs who were cared for similar to Pre-Vitamin A, but with the addition of vitamin A. Outcome variables included the incidence of BPD and other pulmonary and major neonatal morbidities. Results. Between Pre-Vitamin A and Post-Vitamin A the incidence of moderate to severe BPD decreased by 11%, from 33% to 22% (p=0.2). No difference was found in the number of ventilator days or in the incidence of any other neonatal morbidity or mortality, including intraventricular hemorrhage, necrotizing enterocolitis, or patent ductus arteriosus requiring surgical ligation. Conclusion. In a neonatal unit utilizing early surfactant followed by nasal CPAP at delivery, supplementing extremely premature neonates with vitamin A demonstrated a trend towards a decrease in the incidence of moderate to severe BPD; however, this change requires a larger sample to verify in the future.
AB - Objective. The objective of this study was to determine if the continued use of vitamin A in a nursery utilizing early surfactant and nasal continuous positive airway pressure (CPAP) was warranted. Study design.A retrospective, cohort study of appropriately sized, preterm neonates weighing ≤1000g at birth was conducted. Two time periods were compared: Pre-Vitamin A was composed of extremely low birth weight who were routinely cared for with early nasal CPAP (n=76); and Post-Vitamin A (n=102) consisted of ELBWs who were cared for similar to Pre-Vitamin A, but with the addition of vitamin A. Outcome variables included the incidence of BPD and other pulmonary and major neonatal morbidities. Results. Between Pre-Vitamin A and Post-Vitamin A the incidence of moderate to severe BPD decreased by 11%, from 33% to 22% (p=0.2). No difference was found in the number of ventilator days or in the incidence of any other neonatal morbidity or mortality, including intraventricular hemorrhage, necrotizing enterocolitis, or patent ductus arteriosus requiring surgical ligation. Conclusion. In a neonatal unit utilizing early surfactant followed by nasal CPAP at delivery, supplementing extremely premature neonates with vitamin A demonstrated a trend towards a decrease in the incidence of moderate to severe BPD; however, this change requires a larger sample to verify in the future.
KW - bronchopulmonary disease
KW - conventional mechanical ventilation
KW - Nasal continuous positive airway pressure
KW - neonatal respiratory support
KW - prematurity
KW - retinol
UR - http://www.scopus.com/inward/record.url?scp=84055217555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84055217555&partnerID=8YFLogxK
U2 - 10.3109/14767058.2011.561893
DO - 10.3109/14767058.2011.561893
M3 - Article
VL - 25
SP - 84
EP - 88
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
SN - 1476-7058
IS - 1
ER -