Impact of providing vitamin A to the routine pulmonary care of extremely low birth weight infants

Alvaro Moreira, Melinda Caskey, Rafael Fonseca, Michael Malloy, Cara Geary

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective. The objective of this study was to determine if the continued use of vitamin A in a nursery utilizing early surfactant and nasal continuous positive airway pressure (CPAP) was warranted. Study design.A retrospective, cohort study of appropriately sized, preterm neonates weighing ≤1000g at birth was conducted. Two time periods were compared: Pre-Vitamin A was composed of extremely low birth weight who were routinely cared for with early nasal CPAP (n=76); and Post-Vitamin A (n=102) consisted of ELBWs who were cared for similar to Pre-Vitamin A, but with the addition of vitamin A. Outcome variables included the incidence of BPD and other pulmonary and major neonatal morbidities. Results. Between Pre-Vitamin A and Post-Vitamin A the incidence of moderate to severe BPD decreased by 11%, from 33% to 22% (p=0.2). No difference was found in the number of ventilator days or in the incidence of any other neonatal morbidity or mortality, including intraventricular hemorrhage, necrotizing enterocolitis, or patent ductus arteriosus requiring surgical ligation. Conclusion. In a neonatal unit utilizing early surfactant followed by nasal CPAP at delivery, supplementing extremely premature neonates with vitamin A demonstrated a trend towards a decrease in the incidence of moderate to severe BPD; however, this change requires a larger sample to verify in the future.

Original languageEnglish (US)
Pages (from-to)84-88
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume25
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Extremely Low Birth Weight Infant
Vitamin A
Lung
Continuous Positive Airway Pressure
Incidence
Surface-Active Agents
Newborn Infant
Morbidity
Necrotizing Enterocolitis
Patent Ductus Arteriosus
Nurseries
Low Birth Weight Infant
Mechanical Ventilators
Ligation
Cohort Studies
Retrospective Studies
Parturition
Hemorrhage
Mortality

Keywords

  • bronchopulmonary disease
  • conventional mechanical ventilation
  • Nasal continuous positive airway pressure
  • neonatal respiratory support
  • prematurity
  • retinol

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Impact of providing vitamin A to the routine pulmonary care of extremely low birth weight infants. / Moreira, Alvaro; Caskey, Melinda; Fonseca, Rafael; Malloy, Michael; Geary, Cara.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 25, No. 1, 01.2012, p. 84-88.

Research output: Contribution to journalArticle

@article{056984f791ff4f6fb67e8c1c93d46eaf,
title = "Impact of providing vitamin A to the routine pulmonary care of extremely low birth weight infants",
abstract = "Objective. The objective of this study was to determine if the continued use of vitamin A in a nursery utilizing early surfactant and nasal continuous positive airway pressure (CPAP) was warranted. Study design.A retrospective, cohort study of appropriately sized, preterm neonates weighing ≤1000g at birth was conducted. Two time periods were compared: Pre-Vitamin A was composed of extremely low birth weight who were routinely cared for with early nasal CPAP (n=76); and Post-Vitamin A (n=102) consisted of ELBWs who were cared for similar to Pre-Vitamin A, but with the addition of vitamin A. Outcome variables included the incidence of BPD and other pulmonary and major neonatal morbidities. Results. Between Pre-Vitamin A and Post-Vitamin A the incidence of moderate to severe BPD decreased by 11{\%}, from 33{\%} to 22{\%} (p=0.2). No difference was found in the number of ventilator days or in the incidence of any other neonatal morbidity or mortality, including intraventricular hemorrhage, necrotizing enterocolitis, or patent ductus arteriosus requiring surgical ligation. Conclusion. In a neonatal unit utilizing early surfactant followed by nasal CPAP at delivery, supplementing extremely premature neonates with vitamin A demonstrated a trend towards a decrease in the incidence of moderate to severe BPD; however, this change requires a larger sample to verify in the future.",
keywords = "bronchopulmonary disease, conventional mechanical ventilation, Nasal continuous positive airway pressure, neonatal respiratory support, prematurity, retinol",
author = "Alvaro Moreira and Melinda Caskey and Rafael Fonseca and Michael Malloy and Cara Geary",
year = "2012",
month = "1",
doi = "10.3109/14767058.2011.561893",
language = "English (US)",
volume = "25",
pages = "84--88",
journal = "Journal of Maternal-Fetal and Neonatal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Impact of providing vitamin A to the routine pulmonary care of extremely low birth weight infants

AU - Moreira, Alvaro

AU - Caskey, Melinda

AU - Fonseca, Rafael

AU - Malloy, Michael

AU - Geary, Cara

PY - 2012/1

Y1 - 2012/1

N2 - Objective. The objective of this study was to determine if the continued use of vitamin A in a nursery utilizing early surfactant and nasal continuous positive airway pressure (CPAP) was warranted. Study design.A retrospective, cohort study of appropriately sized, preterm neonates weighing ≤1000g at birth was conducted. Two time periods were compared: Pre-Vitamin A was composed of extremely low birth weight who were routinely cared for with early nasal CPAP (n=76); and Post-Vitamin A (n=102) consisted of ELBWs who were cared for similar to Pre-Vitamin A, but with the addition of vitamin A. Outcome variables included the incidence of BPD and other pulmonary and major neonatal morbidities. Results. Between Pre-Vitamin A and Post-Vitamin A the incidence of moderate to severe BPD decreased by 11%, from 33% to 22% (p=0.2). No difference was found in the number of ventilator days or in the incidence of any other neonatal morbidity or mortality, including intraventricular hemorrhage, necrotizing enterocolitis, or patent ductus arteriosus requiring surgical ligation. Conclusion. In a neonatal unit utilizing early surfactant followed by nasal CPAP at delivery, supplementing extremely premature neonates with vitamin A demonstrated a trend towards a decrease in the incidence of moderate to severe BPD; however, this change requires a larger sample to verify in the future.

AB - Objective. The objective of this study was to determine if the continued use of vitamin A in a nursery utilizing early surfactant and nasal continuous positive airway pressure (CPAP) was warranted. Study design.A retrospective, cohort study of appropriately sized, preterm neonates weighing ≤1000g at birth was conducted. Two time periods were compared: Pre-Vitamin A was composed of extremely low birth weight who were routinely cared for with early nasal CPAP (n=76); and Post-Vitamin A (n=102) consisted of ELBWs who were cared for similar to Pre-Vitamin A, but with the addition of vitamin A. Outcome variables included the incidence of BPD and other pulmonary and major neonatal morbidities. Results. Between Pre-Vitamin A and Post-Vitamin A the incidence of moderate to severe BPD decreased by 11%, from 33% to 22% (p=0.2). No difference was found in the number of ventilator days or in the incidence of any other neonatal morbidity or mortality, including intraventricular hemorrhage, necrotizing enterocolitis, or patent ductus arteriosus requiring surgical ligation. Conclusion. In a neonatal unit utilizing early surfactant followed by nasal CPAP at delivery, supplementing extremely premature neonates with vitamin A demonstrated a trend towards a decrease in the incidence of moderate to severe BPD; however, this change requires a larger sample to verify in the future.

KW - bronchopulmonary disease

KW - conventional mechanical ventilation

KW - Nasal continuous positive airway pressure

KW - neonatal respiratory support

KW - prematurity

KW - retinol

UR - http://www.scopus.com/inward/record.url?scp=84055217555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84055217555&partnerID=8YFLogxK

U2 - 10.3109/14767058.2011.561893

DO - 10.3109/14767058.2011.561893

M3 - Article

C2 - 21740337

AN - SCOPUS:84055217555

VL - 25

SP - 84

EP - 88

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

SN - 1476-7058

IS - 1

ER -