Impact of Respiratory Symptoms and Pulmonary Function on Quality of Life of Long-term Survivors of Non-Small Cell Lung Cancer

Linda Sarna, Lorraine Evangelista, Donald Tashkin, Geraldine Padilla, Carmack Holmes, Mary Lynn Brecht, Fred Grannis

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Purpose: To describe respiratory symptoms and pulmonary function among long-term survivors of non-small cell lung cancer (NSCLC), and their relationship to quality of life (QOL). Methods: Cross-sectional survey of disease-free, 5-year minimum survivors of NSCLC (n = 142; 54% women; average age, 71 years); the majority (74%) had received a lobectomy. Analysis included frequency of self-reported respiratory symptoms (cough, phlegm, wheezing, breathlessness) as measured by the American Thoracic Society questionnaire, pulmonary function findings from hand-held spirometry, and QOL (Short Form-36). Results: Two thirds of survivors reported at least one respiratory symptom (mean, 1.3; SD, 1.2): 25% cough, 28% phlegm, 31% wheezing, and 39% dyspnea. Twenty-one percent reported that they spent most of the day in bed in the past 12 months because of respiratory symptoms. Average FEV1 percentage predicted was 68% (SD, 23); 21% had < 50% predicted FEV1. Based on spirometry results, 36% had a moderate/severe obstructive and/or restrictive ventilatory disorder. Survivors exposed to second-hand smoke (28%) were more than three times as likely to report respiratory symptoms. Respiratory symptom burden contributed to diminished QOL in several domains. Conclusions: The majority of these survivors experienced respiratory symptoms, and more than one third reported dyspnea, including one of five patients with seriously diminished pulmonary function. Symptom burden, rather than ventilatory impairment, contributed to diminished QOL. Further study is needed to determine the patterns and effective management of posttreatment respiratory symptoms on survivors of lung cancer.

Original languageEnglish (US)
Pages (from-to)439-445
Number of pages7
JournalChest
Volume125
Issue number2
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

Fingerprint

Non-Small Cell Lung Carcinoma
Survivors
Quality of Life
Lung
Dyspnea
Spirometry
Respiratory Sounds
Cough
Tobacco Smoke Pollution
Lung Neoplasms
Hand
Cross-Sectional Studies

Keywords

  • Cancer survivors
  • Chronic lung disease
  • Lung neoplasms
  • Pulmonary function
  • Quality of life
  • Respiratory symptoms
  • Tobacco, smoking

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Impact of Respiratory Symptoms and Pulmonary Function on Quality of Life of Long-term Survivors of Non-Small Cell Lung Cancer. / Sarna, Linda; Evangelista, Lorraine; Tashkin, Donald; Padilla, Geraldine; Holmes, Carmack; Brecht, Mary Lynn; Grannis, Fred.

In: Chest, Vol. 125, No. 2, 01.01.2004, p. 439-445.

Research output: Contribution to journalArticle

Sarna, Linda ; Evangelista, Lorraine ; Tashkin, Donald ; Padilla, Geraldine ; Holmes, Carmack ; Brecht, Mary Lynn ; Grannis, Fred. / Impact of Respiratory Symptoms and Pulmonary Function on Quality of Life of Long-term Survivors of Non-Small Cell Lung Cancer. In: Chest. 2004 ; Vol. 125, No. 2. pp. 439-445.
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abstract = "Purpose: To describe respiratory symptoms and pulmonary function among long-term survivors of non-small cell lung cancer (NSCLC), and their relationship to quality of life (QOL). Methods: Cross-sectional survey of disease-free, 5-year minimum survivors of NSCLC (n = 142; 54{\%} women; average age, 71 years); the majority (74{\%}) had received a lobectomy. Analysis included frequency of self-reported respiratory symptoms (cough, phlegm, wheezing, breathlessness) as measured by the American Thoracic Society questionnaire, pulmonary function findings from hand-held spirometry, and QOL (Short Form-36). Results: Two thirds of survivors reported at least one respiratory symptom (mean, 1.3; SD, 1.2): 25{\%} cough, 28{\%} phlegm, 31{\%} wheezing, and 39{\%} dyspnea. Twenty-one percent reported that they spent most of the day in bed in the past 12 months because of respiratory symptoms. Average FEV1 percentage predicted was 68{\%} (SD, 23); 21{\%} had < 50{\%} predicted FEV1. Based on spirometry results, 36{\%} had a moderate/severe obstructive and/or restrictive ventilatory disorder. Survivors exposed to second-hand smoke (28{\%}) were more than three times as likely to report respiratory symptoms. Respiratory symptom burden contributed to diminished QOL in several domains. Conclusions: The majority of these survivors experienced respiratory symptoms, and more than one third reported dyspnea, including one of five patients with seriously diminished pulmonary function. Symptom burden, rather than ventilatory impairment, contributed to diminished QOL. Further study is needed to determine the patterns and effective management of posttreatment respiratory symptoms on survivors of lung cancer.",
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AU - Holmes, Carmack

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AB - Purpose: To describe respiratory symptoms and pulmonary function among long-term survivors of non-small cell lung cancer (NSCLC), and their relationship to quality of life (QOL). Methods: Cross-sectional survey of disease-free, 5-year minimum survivors of NSCLC (n = 142; 54% women; average age, 71 years); the majority (74%) had received a lobectomy. Analysis included frequency of self-reported respiratory symptoms (cough, phlegm, wheezing, breathlessness) as measured by the American Thoracic Society questionnaire, pulmonary function findings from hand-held spirometry, and QOL (Short Form-36). Results: Two thirds of survivors reported at least one respiratory symptom (mean, 1.3; SD, 1.2): 25% cough, 28% phlegm, 31% wheezing, and 39% dyspnea. Twenty-one percent reported that they spent most of the day in bed in the past 12 months because of respiratory symptoms. Average FEV1 percentage predicted was 68% (SD, 23); 21% had < 50% predicted FEV1. Based on spirometry results, 36% had a moderate/severe obstructive and/or restrictive ventilatory disorder. Survivors exposed to second-hand smoke (28%) were more than three times as likely to report respiratory symptoms. Respiratory symptom burden contributed to diminished QOL in several domains. Conclusions: The majority of these survivors experienced respiratory symptoms, and more than one third reported dyspnea, including one of five patients with seriously diminished pulmonary function. Symptom burden, rather than ventilatory impairment, contributed to diminished QOL. Further study is needed to determine the patterns and effective management of posttreatment respiratory symptoms on survivors of lung cancer.

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