Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor

Keyphrases

• Drug-like 100%
• Desensitization 100%
• Catechol 100%
• D1 Dopamine Receptor 100%
• D1 Receptor 100%
• Arrestin 100%
• Arrestin Recruitment 100%
• Non-catechol 100%
• Therapeutic Strategies 50%
• Psychiatric Disease 50%
• Pharmacokinetic Properties 50%
• Motor Function 50%
• Selective Agonist 50%
• Rodent Models 50%
• Neurological Diseases 50%
• Receptor Desensitization 50%
• In Vivo Efficacy 50%
• Prolonged Exposure 50%
• Adenylyl Cyclase 50%
• Oral Administration 50%
• Dopamine D1 Receptor 50%
• Novel Class 50%
• Selective Activation 50%
• Parkinson's Disease Model 50%
• Reward Processing 50%
• D1 Agonist 50%
• In Vivo Pharmacokinetics 50%
• Functional Profile 50%
• Orthosteric Site 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Receptor 100%
• Desensitization 100%
• Catechol 100%
• Dopamine 1 Receptor 100%
• Retina S Antigen 100%
• Long Term Exposure 33%
• Adenylate Cyclase 33%
• Neurologic Disease 33%
• Parkinson's Disease 33%
• Catechol Derivative 33%
• Pharmacokinetics 33%
• Oral Administration 33%
• Mental Diseases 33%

Biochemistry, Genetics and Molecular Biology

• Agonist 100%
• Dopamine Receptor D1 100%
• Arrestin 100%
• Adenylate Cyclase 16%
• Receptor down Regulation 16%
• Motor Performance 16%
• Pharmacokinetic Properties 16%