Impaired Glucose Tolerance and Impaired Fasting Glucose

Shobha S. Rao, Phillip Disraeli, Tamara McGregor

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Impaired glucose tolerance and impaired fasting glucose form an intermediate stage in the natural history of diabetes mellitus. From 10 to 15 percent of adults in the United States have one of these conditions. Impaired glucose tolerance is defined as two-hour glucose levels of 140 to 199 mg per dL (7.8 to 11.0 mmol) on the 75-g oral glucose tolerance test, and impaired fasting glucose is defined as glucose levels of 100 to 125 mg per dL (5.6 to 6. 9 mmol per L) in fasting patients. These glucose levels are above normal but below the level that is diagnostic for diabetes. Patients with impaired glucose tolerance or impaired fasting glucose have a significant risk of developing diabetes and thus are an important target group for primary prevention. Risk factors for diabetes include family history of diabetes, body mass index greater than 25 kg per m2, sedentary lifestyle, hypertension, dyslipidemia, history of gestational diabetes or large-for-gestational-age infant, and polycystic ovary syndrome. Blacks, Latin Americans, Native Americans, and Asian-Pacific Islanders also are at increased risk for diabetes. Patients at higher risk should be screened with a fasting plasma glucose level. When the diagnosis of impaired glucose tolerance or impaired fasting glucose is made, physicians should counsel patients to lose 5 to 7 percent of their body weight and engage in moderate physical activity for at least 150 minutes per week. Drug therapy with metformin or acarbose has been shown to delay or prevent the onset of diabetes. However, medications are not as effective as lifestyle changes, and it is not known if treatment with these drugs is cost effective in the management of impaired glucose tolerance.

Original languageEnglish (US)
Pages (from-to)1961-1968+1971
JournalAmerican Family Physician
Volume69
Issue number8
StatePublished - Apr 15 2004
Externally publishedYes

Fingerprint

Glucose Intolerance
Fasting
Glucose
Acarbose
Sedentary Lifestyle
Drug Costs
Asian Americans
Gestational Diabetes
North American Indians
Polycystic Ovary Syndrome
Metformin
Primary Prevention
Glucose Tolerance Test
Dyslipidemias
Gestational Age
Life Style
Diabetes Mellitus
Body Mass Index
Body Weight
Exercise

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rao, S. S., Disraeli, P., & McGregor, T. (2004). Impaired Glucose Tolerance and Impaired Fasting Glucose. American Family Physician, 69(8), 1961-1968+1971.

Impaired Glucose Tolerance and Impaired Fasting Glucose. / Rao, Shobha S.; Disraeli, Phillip; McGregor, Tamara.

In: American Family Physician, Vol. 69, No. 8, 15.04.2004, p. 1961-1968+1971.

Research output: Contribution to journalArticle

Rao, SS, Disraeli, P & McGregor, T 2004, 'Impaired Glucose Tolerance and Impaired Fasting Glucose', American Family Physician, vol. 69, no. 8, pp. 1961-1968+1971.
Rao SS, Disraeli P, McGregor T. Impaired Glucose Tolerance and Impaired Fasting Glucose. American Family Physician. 2004 Apr 15;69(8):1961-1968+1971.
Rao, Shobha S. ; Disraeli, Phillip ; McGregor, Tamara. / Impaired Glucose Tolerance and Impaired Fasting Glucose. In: American Family Physician. 2004 ; Vol. 69, No. 8. pp. 1961-1968+1971.
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