Impaired glucose tolerance in pediatric burn patients at discharge from the acute hospital stay

Ricki Y. Fram, Melanie G. Cree, Robert R. Wolfe, David Barr, David Herndon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Hyperglycemia, secondary to the hypermetabolic stress response, is a common occurrence after thermal injury. This stress response has been documented to persist up to 9 months postburn. The purpose of this study was to measure insulin sensitivity in severely burned children before discharge when wounds are 95% healed. Twenty-four children, aged 4 to 17 years, with burns ≥40% TBSA underwent a 2-hour oral glucose tolerance test before discharge from the acute pediatric burn unit. Plasma glucose and insulin levels as well as the Homeostasis Model Assessment for Insulin Resistance (HOMAIR) were compared with published oral glucose tolerance test data from healthy, nonburned children. There was a significant difference between severely burned children and nonburned, healthy children with respect to the HOMAIR. Severely burned children had a HOMAIR of 3.53 ± 1.62 compared with the value in nonburned, healthy children of 1.28 ± 0.16 (P < .05). Insulin resistance secondary to the hypermetabolic stress response persists in severely burned children when burn wounds are at least 95% healed. The results of this study warrant future investigations into therapeutic options for the burned child during the rehabilitative phase of their care after injury.

Original languageEnglish (US)
Pages (from-to)728-733
Number of pages6
JournalJournal of Burn Care and Research
Volume31
Issue number5
DOIs
StatePublished - Sep 2010

Fingerprint

Glucose Intolerance
Patient Discharge
Length of Stay
Pediatrics
Insulin Resistance
Homeostasis
Wounds and Injuries
Glucose Tolerance Test
Burn Units
Burns
Hyperglycemia
Hot Temperature
Insulin
Glucose

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery

Cite this

Impaired glucose tolerance in pediatric burn patients at discharge from the acute hospital stay. / Fram, Ricki Y.; Cree, Melanie G.; Wolfe, Robert R.; Barr, David; Herndon, David.

In: Journal of Burn Care and Research, Vol. 31, No. 5, 09.2010, p. 728-733.

Research output: Contribution to journalArticle

Fram, Ricki Y. ; Cree, Melanie G. ; Wolfe, Robert R. ; Barr, David ; Herndon, David. / Impaired glucose tolerance in pediatric burn patients at discharge from the acute hospital stay. In: Journal of Burn Care and Research. 2010 ; Vol. 31, No. 5. pp. 728-733.
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