Impaired Interoception in a Preclinical Model of Functional Dyspepsia

John Winston, Jose E. Aguirre, Xuan-Zheng Shi, Sushil K. Sarna

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: The etiologies of functional dyspepsia symptoms, including postprandial distress syndrome, remain unknown. We tested the hypothesis that neonatal colon inflammation induces postprandial distress syndrome-like symptoms in adult life that associate with increased activation of vagal afferent pathways and forebrain limbic regions. Results: These rats showed a significant decrease in nutrient meal consumption to satiety after an overnight fast, decrease in gastric emptying, decrease in total distance traveled, and decrease in percent distance traveled in midfield versus control rats in open field test, indicating postprandial anxiety- and depression-like behaviors. Adult naïve rats treated with oral iodoacetamide to induce H. pylori-like mild gastritis demonstrated similar postprandial effects as the above rats. Conclusions: We concluded that neonatal colon inflammation is a risk factor for the development of postprandial distress syndrome-like symptoms. While mild gastritis can induce symptoms similar to those of neonatal colon inflammation, gastritis in these rats does not worsen the symptoms.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalDigestive Diseases and Sciences
DOIs
StateAccepted/In press - Mar 29 2017

Fingerprint

Dyspepsia
Gastritis
Colon
Inflammation
Iodoacetamide
Afferent Pathways
Gastric Emptying
Pylorus
Prosencephalon
Meals
Anxiety
Interoception
Depression
Food

Keywords

  • Anxiety
  • Functional dyspepsia
  • Gastric emptying
  • Visceral hypersensitivity
  • Visceral pain

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Impaired Interoception in a Preclinical Model of Functional Dyspepsia. / Winston, John; Aguirre, Jose E.; Shi, Xuan-Zheng; Sarna, Sushil K.

In: Digestive Diseases and Sciences, 29.03.2017, p. 1-11.

Research output: Contribution to journalArticle

@article{50e1781830674feb838460fb3f3ca028,
title = "Impaired Interoception in a Preclinical Model of Functional Dyspepsia",
abstract = "Introduction: The etiologies of functional dyspepsia symptoms, including postprandial distress syndrome, remain unknown. We tested the hypothesis that neonatal colon inflammation induces postprandial distress syndrome-like symptoms in adult life that associate with increased activation of vagal afferent pathways and forebrain limbic regions. Results: These rats showed a significant decrease in nutrient meal consumption to satiety after an overnight fast, decrease in gastric emptying, decrease in total distance traveled, and decrease in percent distance traveled in midfield versus control rats in open field test, indicating postprandial anxiety- and depression-like behaviors. Adult na{\"i}ve rats treated with oral iodoacetamide to induce H. pylori-like mild gastritis demonstrated similar postprandial effects as the above rats. Conclusions: We concluded that neonatal colon inflammation is a risk factor for the development of postprandial distress syndrome-like symptoms. While mild gastritis can induce symptoms similar to those of neonatal colon inflammation, gastritis in these rats does not worsen the symptoms.",
keywords = "Anxiety, Functional dyspepsia, Gastric emptying, Visceral hypersensitivity, Visceral pain",
author = "John Winston and Aguirre, {Jose E.} and Xuan-Zheng Shi and Sarna, {Sushil K.}",
year = "2017",
month = "3",
day = "29",
doi = "10.1007/s10620-017-4487-0",
language = "English (US)",
pages = "1--11",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",

}

TY - JOUR

T1 - Impaired Interoception in a Preclinical Model of Functional Dyspepsia

AU - Winston, John

AU - Aguirre, Jose E.

AU - Shi, Xuan-Zheng

AU - Sarna, Sushil K.

PY - 2017/3/29

Y1 - 2017/3/29

N2 - Introduction: The etiologies of functional dyspepsia symptoms, including postprandial distress syndrome, remain unknown. We tested the hypothesis that neonatal colon inflammation induces postprandial distress syndrome-like symptoms in adult life that associate with increased activation of vagal afferent pathways and forebrain limbic regions. Results: These rats showed a significant decrease in nutrient meal consumption to satiety after an overnight fast, decrease in gastric emptying, decrease in total distance traveled, and decrease in percent distance traveled in midfield versus control rats in open field test, indicating postprandial anxiety- and depression-like behaviors. Adult naïve rats treated with oral iodoacetamide to induce H. pylori-like mild gastritis demonstrated similar postprandial effects as the above rats. Conclusions: We concluded that neonatal colon inflammation is a risk factor for the development of postprandial distress syndrome-like symptoms. While mild gastritis can induce symptoms similar to those of neonatal colon inflammation, gastritis in these rats does not worsen the symptoms.

AB - Introduction: The etiologies of functional dyspepsia symptoms, including postprandial distress syndrome, remain unknown. We tested the hypothesis that neonatal colon inflammation induces postprandial distress syndrome-like symptoms in adult life that associate with increased activation of vagal afferent pathways and forebrain limbic regions. Results: These rats showed a significant decrease in nutrient meal consumption to satiety after an overnight fast, decrease in gastric emptying, decrease in total distance traveled, and decrease in percent distance traveled in midfield versus control rats in open field test, indicating postprandial anxiety- and depression-like behaviors. Adult naïve rats treated with oral iodoacetamide to induce H. pylori-like mild gastritis demonstrated similar postprandial effects as the above rats. Conclusions: We concluded that neonatal colon inflammation is a risk factor for the development of postprandial distress syndrome-like symptoms. While mild gastritis can induce symptoms similar to those of neonatal colon inflammation, gastritis in these rats does not worsen the symptoms.

KW - Anxiety

KW - Functional dyspepsia

KW - Gastric emptying

KW - Visceral hypersensitivity

KW - Visceral pain

UR - http://www.scopus.com/inward/record.url?scp=85016424337&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016424337&partnerID=8YFLogxK

U2 - 10.1007/s10620-017-4487-0

DO - 10.1007/s10620-017-4487-0

M3 - Article

SP - 1

EP - 11

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

ER -