Impaired Interoception in a Preclinical Model of Functional Dyspepsia

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3 Scopus citations

Abstract

Introduction: The etiologies of functional dyspepsia symptoms, including postprandial distress syndrome, remain unknown. We tested the hypothesis that neonatal colon inflammation induces postprandial distress syndrome-like symptoms in adult life that associate with increased activation of vagal afferent pathways and forebrain limbic regions. Results: These rats showed a significant decrease in nutrient meal consumption to satiety after an overnight fast, decrease in gastric emptying, decrease in total distance traveled, and decrease in percent distance traveled in midfield versus control rats in open field test, indicating postprandial anxiety- and depression-like behaviors. Adult naïve rats treated with oral iodoacetamide to induce H. pylori-like mild gastritis demonstrated similar postprandial effects as the above rats. Conclusions: We concluded that neonatal colon inflammation is a risk factor for the development of postprandial distress syndrome-like symptoms. While mild gastritis can induce symptoms similar to those of neonatal colon inflammation, gastritis in these rats does not worsen the symptoms.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalDigestive Diseases and Sciences
DOIs
StateAccepted/In press - Mar 29 2017

Keywords

  • Anxiety
  • Functional dyspepsia
  • Gastric emptying
  • Visceral hypersensitivity
  • Visceral pain

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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