Impaired ocular blood flow regulation in patients with open-angle glaucoma and diabetes

Yochai Shoshani, Alon Harris, Mohammadali Mohajel Shoja, Yoel Arieli, Rita Ehrlich, Sally Primus, Thomas Ciulla, Adam Cantor, Barbara Wirostko, Brent A. Siesky

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: To elucidate the potential impact of diabetes mellitus on primary open-angle glaucoma pathology through vascular deficiency. Design: Cross-section analysis from a longitudinal, prospective study. Participants: Eighty-four open-angle glaucoma patients (20 diabetic open-angle glaucoma patients and 64 non-diabetic open-angle glaucoma patients) Methods: Patients were analyzed for ocular structure, ocular perfusion pressure (OPP), retrobulbar blood flow and retinal capillary perfusion. Statistical analysis was performed by SPSS version 18.0. Comparisons between groups were made as well as multivariate linear regression analysis. Main Outcome Measure: Retrobulbar blood flow and the retinal microcirculation. Results: Central retinal artery peak systolic velocity was 13.5% lower in diabetic patients (P=0.007). In diabetic open-angle glaucoma patients, ocular perfusion pressure positively correlated with central retinal artery and temporal posterior ciliary artery peak systolic velocity (R=0.476, P=0.039 and R=0.529, P=0.02, respectively), and with central retinal artery and nasal posterior ciliary artery resistance index (R=0.537, P=0.018 and R=0.566, P=0.012 respectively). Average retinal nerve fibre layer positively correlated with central retinal artery peak systolic velocity and temporal posterior ciliary artery end diastolic velocity (R=0.501, P=0.029 and R=0.553, P=0.019, respectively), and negatively correlated with superior and inferior retinal avascular space in the diabetic group (R=-0.498, P=0.030 and R=-0.700, P=0.001, respectively); no correlations were found in the non-diabetic group. Negative correlations between retrobulbar and retinal circulations were only found in the diabetic open-angle glaucoma patients, whereas positive correlations between retinal flow and non-flow were only found in non-diabetic open-angle glaucoma patients. Conclusion: Diabetes may interfere with normal vascular regulation and contribute to glaucoma progression.

Original languageEnglish (US)
Pages (from-to)697-705
Number of pages9
JournalClinical and Experimental Ophthalmology
Volume40
Issue number7
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

Fingerprint

Open Angle Glaucoma
Retinal Artery
Ciliary Arteries
Perfusion
Blood Vessels
Microcirculation
Nerve Fibers
Nose
Glaucoma
Longitudinal Studies
Linear Models
Diabetes Mellitus
Regression Analysis
Outcome Assessment (Health Care)
Prospective Studies
Pathology
Blood Pressure
Pressure

Keywords

  • Diabetes
  • Glaucoma
  • Retinal microcirculation
  • Retrobulbar blood flow

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Shoshani, Y., Harris, A., Mohajel Shoja, M., Arieli, Y., Ehrlich, R., Primus, S., ... Siesky, B. A. (2012). Impaired ocular blood flow regulation in patients with open-angle glaucoma and diabetes. Clinical and Experimental Ophthalmology, 40(7), 697-705. https://doi.org/10.1111/j.1442-9071.2012.02778.x

Impaired ocular blood flow regulation in patients with open-angle glaucoma and diabetes. / Shoshani, Yochai; Harris, Alon; Mohajel Shoja, Mohammadali; Arieli, Yoel; Ehrlich, Rita; Primus, Sally; Ciulla, Thomas; Cantor, Adam; Wirostko, Barbara; Siesky, Brent A.

In: Clinical and Experimental Ophthalmology, Vol. 40, No. 7, 01.09.2012, p. 697-705.

Research output: Contribution to journalArticle

Shoshani, Y, Harris, A, Mohajel Shoja, M, Arieli, Y, Ehrlich, R, Primus, S, Ciulla, T, Cantor, A, Wirostko, B & Siesky, BA 2012, 'Impaired ocular blood flow regulation in patients with open-angle glaucoma and diabetes', Clinical and Experimental Ophthalmology, vol. 40, no. 7, pp. 697-705. https://doi.org/10.1111/j.1442-9071.2012.02778.x
Shoshani, Yochai ; Harris, Alon ; Mohajel Shoja, Mohammadali ; Arieli, Yoel ; Ehrlich, Rita ; Primus, Sally ; Ciulla, Thomas ; Cantor, Adam ; Wirostko, Barbara ; Siesky, Brent A. / Impaired ocular blood flow regulation in patients with open-angle glaucoma and diabetes. In: Clinical and Experimental Ophthalmology. 2012 ; Vol. 40, No. 7. pp. 697-705.
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AU - Ehrlich, Rita

AU - Primus, Sally

AU - Ciulla, Thomas

AU - Cantor, Adam

AU - Wirostko, Barbara

AU - Siesky, Brent A.

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N2 - Background: To elucidate the potential impact of diabetes mellitus on primary open-angle glaucoma pathology through vascular deficiency. Design: Cross-section analysis from a longitudinal, prospective study. Participants: Eighty-four open-angle glaucoma patients (20 diabetic open-angle glaucoma patients and 64 non-diabetic open-angle glaucoma patients) Methods: Patients were analyzed for ocular structure, ocular perfusion pressure (OPP), retrobulbar blood flow and retinal capillary perfusion. Statistical analysis was performed by SPSS version 18.0. Comparisons between groups were made as well as multivariate linear regression analysis. Main Outcome Measure: Retrobulbar blood flow and the retinal microcirculation. Results: Central retinal artery peak systolic velocity was 13.5% lower in diabetic patients (P=0.007). In diabetic open-angle glaucoma patients, ocular perfusion pressure positively correlated with central retinal artery and temporal posterior ciliary artery peak systolic velocity (R=0.476, P=0.039 and R=0.529, P=0.02, respectively), and with central retinal artery and nasal posterior ciliary artery resistance index (R=0.537, P=0.018 and R=0.566, P=0.012 respectively). Average retinal nerve fibre layer positively correlated with central retinal artery peak systolic velocity and temporal posterior ciliary artery end diastolic velocity (R=0.501, P=0.029 and R=0.553, P=0.019, respectively), and negatively correlated with superior and inferior retinal avascular space in the diabetic group (R=-0.498, P=0.030 and R=-0.700, P=0.001, respectively); no correlations were found in the non-diabetic group. Negative correlations between retrobulbar and retinal circulations were only found in the diabetic open-angle glaucoma patients, whereas positive correlations between retinal flow and non-flow were only found in non-diabetic open-angle glaucoma patients. Conclusion: Diabetes may interfere with normal vascular regulation and contribute to glaucoma progression.

AB - Background: To elucidate the potential impact of diabetes mellitus on primary open-angle glaucoma pathology through vascular deficiency. Design: Cross-section analysis from a longitudinal, prospective study. Participants: Eighty-four open-angle glaucoma patients (20 diabetic open-angle glaucoma patients and 64 non-diabetic open-angle glaucoma patients) Methods: Patients were analyzed for ocular structure, ocular perfusion pressure (OPP), retrobulbar blood flow and retinal capillary perfusion. Statistical analysis was performed by SPSS version 18.0. Comparisons between groups were made as well as multivariate linear regression analysis. Main Outcome Measure: Retrobulbar blood flow and the retinal microcirculation. Results: Central retinal artery peak systolic velocity was 13.5% lower in diabetic patients (P=0.007). In diabetic open-angle glaucoma patients, ocular perfusion pressure positively correlated with central retinal artery and temporal posterior ciliary artery peak systolic velocity (R=0.476, P=0.039 and R=0.529, P=0.02, respectively), and with central retinal artery and nasal posterior ciliary artery resistance index (R=0.537, P=0.018 and R=0.566, P=0.012 respectively). Average retinal nerve fibre layer positively correlated with central retinal artery peak systolic velocity and temporal posterior ciliary artery end diastolic velocity (R=0.501, P=0.029 and R=0.553, P=0.019, respectively), and negatively correlated with superior and inferior retinal avascular space in the diabetic group (R=-0.498, P=0.030 and R=-0.700, P=0.001, respectively); no correlations were found in the non-diabetic group. Negative correlations between retrobulbar and retinal circulations were only found in the diabetic open-angle glaucoma patients, whereas positive correlations between retinal flow and non-flow were only found in non-diabetic open-angle glaucoma patients. Conclusion: Diabetes may interfere with normal vascular regulation and contribute to glaucoma progression.

KW - Diabetes

KW - Glaucoma

KW - Retinal microcirculation

KW - Retrobulbar blood flow

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