Impaired zinc and copper status in children with burn injuries

Need to reassess nutritional requirements

V. Saroja Voruganti, Gordon L. Klein, Hong Xing Lu, Suchmor Thomas, Jeanne H. Freeland-Graves, David Herndon

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Major burns are associated with impaired Zn and Cu status. These micronutrients are essential for bone matrix formation, linear growth, and wound healing. This study evaluated the status of Zn and Cu in burned children and assessed adequacy of supplementation. Six children, mean total body surface area (TBSA), 54 ± 9% (S.D.), were recruited. Nutrient intakes, plasma, wound exudate, and 24 h urine samples were collected and analyzed for Zn and Cu. Bone mineral content was assessed by dual energy X-ray absorptiometry. Dietary Zn and Cu were three times the dietary reference, and mean plasma concentrations of Zn and Cu were low at admission and discharge. Urinary Zn was elevated at admission, whereas Cu was elevated at both times. Wound Zn and Cu concentrations exceeded plasma concentrations, suggesting that inflammatory wound exudate was a primary route of loss. We demonstrate that burn injury in children results in low plasma levels of Zn and Cu that are inadequately compensated during hospitalization.

Original languageEnglish (US)
Pages (from-to)711-716
Number of pages6
JournalBurns
Volume31
Issue number6
DOIs
StatePublished - Sep 2005

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Nutritional Requirements
Zinc
Copper
Wounds and Injuries
Exudates and Transudates
Bone Matrix
Micronutrients
Body Surface Area
Photon Absorptiometry
Burns
Osteogenesis
Bone Density
Wound Healing
Hospitalization
Urine
Food
Growth

Keywords

  • Burns
  • Copper
  • Nutritional requirements
  • Wound exudate
  • Zinc

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

Cite this

Voruganti, V. S., Klein, G. L., Lu, H. X., Thomas, S., Freeland-Graves, J. H., & Herndon, D. (2005). Impaired zinc and copper status in children with burn injuries: Need to reassess nutritional requirements. Burns, 31(6), 711-716. https://doi.org/10.1016/j.burns.2005.04.026

Impaired zinc and copper status in children with burn injuries : Need to reassess nutritional requirements. / Voruganti, V. Saroja; Klein, Gordon L.; Lu, Hong Xing; Thomas, Suchmor; Freeland-Graves, Jeanne H.; Herndon, David.

In: Burns, Vol. 31, No. 6, 09.2005, p. 711-716.

Research output: Contribution to journalArticle

Voruganti, VS, Klein, GL, Lu, HX, Thomas, S, Freeland-Graves, JH & Herndon, D 2005, 'Impaired zinc and copper status in children with burn injuries: Need to reassess nutritional requirements', Burns, vol. 31, no. 6, pp. 711-716. https://doi.org/10.1016/j.burns.2005.04.026
Voruganti, V. Saroja ; Klein, Gordon L. ; Lu, Hong Xing ; Thomas, Suchmor ; Freeland-Graves, Jeanne H. ; Herndon, David. / Impaired zinc and copper status in children with burn injuries : Need to reassess nutritional requirements. In: Burns. 2005 ; Vol. 31, No. 6. pp. 711-716.
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