Implantation of rat islet-filled micromachined biocapsules in mice

Tejal A. Desai, Derek J. Hansford, Mauro Ferrari, Cristiana Rastellini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study investigates whether microfabricated silicon-based biocapsules, with uniform membrane pore sizes in the tens of nanometer range, can provide immunoprotection of rat islets transplanted into a mouse model. By utilizing microfabrication technology, biocapsules are fabricated with membranes having precisely controlled and uniform pore sizes, allowing one to optimize parameters specifically for the immunoisolation of hormone-secreting cells. The study evaluates biocompatibility and short term therapeutic efficacy for implanted biocapsules.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
ISSN (Print)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Desai, T. A., Hansford, D. J., Ferrari, M., & Rastellini, C. (1999). Implantation of rat islet-filled micromachined biocapsules in mice. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 2). IEEE.