Implantation of rat islet-filled micromachined biocapsules in mice

Tejal A. Desai, Derek J. Hansford, Mauro Ferrari, Cristiana Rastellini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study investigates whether microfabricated silicon-based biocapsules, with uniform membrane pore sizes in the tens of nanometer range, can provide immunoprotection of rat islets transplanted into a mouse model. By utilizing microfabrication technology, biocapsules are fabricated with membranes having precisely controlled and uniform pore sizes, allowing one to optimize parameters specifically for the immunoisolation of hormone-secreting cells. The study evaluates biocompatibility and short term therapeutic efficacy for implanted biocapsules.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Place of PublicationPiscataway, NJ, United States
PublisherIEEE
Pages749
Number of pages1
Volume2
ISBN (Print)0780356756
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

Fingerprint

Pore size
Rats
Membranes
Microfabrication
Hormones
Silicon
Biocompatibility

ASJC Scopus subject areas

  • Bioengineering

Cite this

Desai, T. A., Hansford, D. J., Ferrari, M., & Rastellini, C. (1999). Implantation of rat islet-filled micromachined biocapsules in mice. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2, pp. 749). Piscataway, NJ, United States: IEEE.

Implantation of rat islet-filled micromachined biocapsules in mice. / Desai, Tejal A.; Hansford, Derek J.; Ferrari, Mauro; Rastellini, Cristiana.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 Piscataway, NJ, United States : IEEE, 1999. p. 749.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Desai, TA, Hansford, DJ, Ferrari, M & Rastellini, C 1999, Implantation of rat islet-filled micromachined biocapsules in mice. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 2, IEEE, Piscataway, NJ, United States, pp. 749, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 10/13/99.
Desai TA, Hansford DJ, Ferrari M, Rastellini C. Implantation of rat islet-filled micromachined biocapsules in mice. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2. Piscataway, NJ, United States: IEEE. 1999. p. 749
Desai, Tejal A. ; Hansford, Derek J. ; Ferrari, Mauro ; Rastellini, Cristiana. / Implantation of rat islet-filled micromachined biocapsules in mice. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 Piscataway, NJ, United States : IEEE, 1999. pp. 749
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