Improved 6 Minute Walk Distance and Brain-Type Natriuretic Peptide after Continuous-Flow Ventricular Assist Device Placement in Children

Jason F. Goldberg, Robin S. Schlosser, James G. Walrath, Shaine A. Morris, Barbara A. Elias, Jack F. Price, Antonio G. Cabrera, Susan W. Denfield, Wiliam J. Dreyer, Yunfei Wang, Iki Adachi, Aamir Jeewa

Research output: Contribution to journalArticlepeer-review

Abstract

Despite increasing continuous-flow ventricular assist device (CF-VAD) use in children, minimal data exist regarding the functional recovery and rehabilitation potential after device placement. We hypothesized that after CF-VAD implantation, children would demonstrate a time-limited improvement in 6 minute walk distance (6MWD) and brain-type natriuretic peptide (BNP). A retrospective cohort study of 27 patients was conducted, those <18 years of age at a tertiary-care center during the study period. Seventy-four percent were male; median age was 12.7 years. Six minute walk distance and BNP were evaluated within 365 days of implantation. Associations were examined before and after 90 days postimplantation because a plateau in both values was seen after 90 days. Data included 92 6MWD and 341 BNP values. In the first 90 days, 6MWD increased by 12 percent predicted (%P) per 30 days (P < 0.01); with no significant change thereafter, increasing 0.6 %P per 30 days (P = 0.482). In the first 90 days, BNP decreased by 59% per 30 days (P < 0.01); with no significant change thereafter, increasing 1.2% per 30 days (P = 0.561). Six minute walk distance and BNP improved after CF-VAD implantation, with a significant improvement only in the first 90 days. Routine use of 6MWD and BNP can help in assessment of functional recovery in children after CF-VAD placement.

Original languageEnglish (US)
Pages (from-to)725-730
Number of pages6
JournalASAIO Journal
Volume65
Issue number7
DOIs
StatePublished - Sep 1 2019
Externally publishedYes

Keywords

  • heart failure
  • heart-assist devices
  • mechanical circulatory support
  • pediatrics
  • rehabilitation

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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