Improved growth and decreased morbidities in <1000g neonates after early management changes

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: To test the hypothesis that three changes in the early management of extremely low birth weight (ELBW) neonates would decrease the incidence of extra-uterine growth restriction (EUGR) by 25%. The three early management practice changes (EMPC) included surfactant at delivery followed by immediate extubation to nasal continuous positive airway pressure (CPAP), decreased oxygen exposure and early parenteral amino acids. Study Design: Historical cohort study of preterm infants ≤ 1000g birth weight (BW) born at the University of Texas Medical Branch between January 2001 and June 2002 (pre-EMPC, before changes, n=87) and July 2004 to December 2005 (post-EMPC, after changes, n=76). Outcomes measured included feeding and growth parameters, morbidities and interventions. Statistical analysis included χ2-analysis, Student's t-test, and analysis of variance. Result: Infants in the post-EMPC cohort regained BW more quickly, maintained appropriate size for weight at 36 weeks and had less morbidity associated with poor long-term outcome. Predictors of EUGR included BW <750g and surgical necrotizing enterocolitis. Conclusion: The introduction of surfactant at delivery followed by immediate extubation to CPAP, decreased oxygen exposure and early parenteral amino acids in ELBW infants is possible, safe and associated with improvements in growth and morbidity.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalJournal of Perinatology
Volume28
Issue number5
DOIs
StatePublished - May 2008

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Practice Management
Birth Weight
Newborn Infant
Morbidity
Continuous Positive Airway Pressure
Growth
Surface-Active Agents
Extremely Low Birth Weight Infant
Oxygen
Amino Acids
Necrotizing Enterocolitis
Low Birth Weight Infant
Premature Infants
Analysis of Variance
Cohort Studies
Students
Weights and Measures
Incidence

Keywords

  • Delivery room CPAP
  • Early amino acids
  • Extra-uterine growth restriction
  • Neonatal nutrition and growth
  • Neurodevelopmental delay
  • Surfactant

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Improved growth and decreased morbidities in <1000g neonates after early management changes. / Geary, Cara; Fonseca, Rafael; Caskey, M. A.; Malloy, Michael.

In: Journal of Perinatology, Vol. 28, No. 5, 05.2008, p. 347-353.

Research output: Contribution to journalArticle

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