Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure

Faidon Magkos, Yannis Tsekouras, Stavros A. Kavouras, Bettina Mittendorfer, Labros S. Sidossis

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A single bout of moderate-intensity exercise increases whole-body insulin sensitivity for 12-48 h post-exercise; however, the relationship between exercise energy expenditure and the improvement in insulin sensitivity is not known. We hypothesized that the exercise-induced increase in whole-body insulin sensitivity, assessed with HOMAIR (homoeostasis model assessment of insulin resistance), is directly related to the energy expended during exercise. We studied 30 recreationally active non-obese men (age, 27 ± 5 years; body mass index, 24 ± 2 kg/m2) in the post-absorptive state on two separate occasions: once after exercising at 60% of V̇O2peak (peak oxygen consumption) for 30-120 min on the preceding afternoon (expending a total of 1.28-5.76 MJ) and once after an equivalent period of rest. Blood samples were obtained the following morning. Exercise-induced changes in HOMAIR were curvilinearly related to exercise energy expenditure (r = -0.666, P = 0.001) with a threshold of approx. 3.77 MJ (900 kcal) for improvements in HOMAIR to be manifested. In particular, HOMA IR was reduced by 32 ± 24 % (P = 0.003) in subjects who expended more than 3.77 MJ during exercise, but did not change for those who expended fewer than 3.77 MJ (-2 ± 21%; P = 0.301). Furthermore, the magnitude of change in HOMAIR after exercise was directly associated with baseline (i.e. resting) HOMAIR (r = -0.508, P = 0.004); this relationship persisted in multivariate analysis. We conclude that improved whole-body insulin resistance after a single bout of exercise is curvilinearly related to exercise energy expenditure, and requires unfeasible amounts of exercise for most sedentary individuals.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalClinical Science
Volume114
Issue number1-2
DOIs
StatePublished - Jan 2008
Externally publishedYes

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Energy Metabolism
Insulin Resistance
Exercise
Homeostasis
Oxygen Consumption
Body Mass Index
Multivariate Analysis

Keywords

  • Energy expenditure
  • Exercise
  • Glucose disposal
  • Homoeostasis model assessment of insulin resistance (HOMA)
  • Insulin sensitivity
  • Oxygen consumption (V̇o)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure. / Magkos, Faidon; Tsekouras, Yannis; Kavouras, Stavros A.; Mittendorfer, Bettina; Sidossis, Labros S.

In: Clinical Science, Vol. 114, No. 1-2, 01.2008, p. 59-64.

Research output: Contribution to journalArticle

Magkos, F, Tsekouras, Y, Kavouras, SA, Mittendorfer, B & Sidossis, LS 2008, 'Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure', Clinical Science, vol. 114, no. 1-2, pp. 59-64. https://doi.org/10.1042/CS20070134
Magkos, Faidon ; Tsekouras, Yannis ; Kavouras, Stavros A. ; Mittendorfer, Bettina ; Sidossis, Labros S. / Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure. In: Clinical Science. 2008 ; Vol. 114, No. 1-2. pp. 59-64.
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abstract = "A single bout of moderate-intensity exercise increases whole-body insulin sensitivity for 12-48 h post-exercise; however, the relationship between exercise energy expenditure and the improvement in insulin sensitivity is not known. We hypothesized that the exercise-induced increase in whole-body insulin sensitivity, assessed with HOMAIR (homoeostasis model assessment of insulin resistance), is directly related to the energy expended during exercise. We studied 30 recreationally active non-obese men (age, 27 ± 5 years; body mass index, 24 ± 2 kg/m2) in the post-absorptive state on two separate occasions: once after exercising at 60{\%} of V̇O2peak (peak oxygen consumption) for 30-120 min on the preceding afternoon (expending a total of 1.28-5.76 MJ) and once after an equivalent period of rest. Blood samples were obtained the following morning. Exercise-induced changes in HOMAIR were curvilinearly related to exercise energy expenditure (r = -0.666, P = 0.001) with a threshold of approx. 3.77 MJ (900 kcal) for improvements in HOMAIR to be manifested. In particular, HOMA IR was reduced by 32 ± 24 {\%} (P = 0.003) in subjects who expended more than 3.77 MJ during exercise, but did not change for those who expended fewer than 3.77 MJ (-2 ± 21{\%}; P = 0.301). Furthermore, the magnitude of change in HOMAIR after exercise was directly associated with baseline (i.e. resting) HOMAIR (r = -0.508, P = 0.004); this relationship persisted in multivariate analysis. We conclude that improved whole-body insulin resistance after a single bout of exercise is curvilinearly related to exercise energy expenditure, and requires unfeasible amounts of exercise for most sedentary individuals.",
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