Improvement of venous leg ulcers with androgen replacement therapy in a patient with undiagnosed klinefelter syndrome

Shwetha Thukuntla; Pratima Kumar

doi:10.4161/derm.3.4.15333

Improvement of venous leg ulcers with androgen replacement therapy in a patient with undiagnosed klinefelter syndrome

Shwetha Thukuntla
, Pratima Kumar

Internal Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Klinefelter syndrome (Ks) is the most common genetic form of male hypogonadism. The majority (80-90%) of patients have 47, XXY karyotype while mosaicism is seen in only 10-20% of patients. Leg ulcers may be a presenting symptom of KS with a prevalence of 6-13%. Treatment with testosterone has been reported to improve the ulcers.

Original language	English (US)
Pages (from-to)	233-234
Number of pages	2
Journal	Dermato-Endocrinology
Volume	3
Issue number	4
DOIs	https://doi.org/10.4161/derm.3.4.15333
State	Published - Oct 2011

Keywords

Androgen therapy
Klinefelter syndrome
Leg ulcers
Mosaicism
Plasminogen activator inhibitor

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Dermatology

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10.4161/derm.3.4.15333

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title = "Improvement of venous leg ulcers with androgen replacement therapy in a patient with undiagnosed klinefelter syndrome",

abstract = "Klinefelter syndrome (Ks) is the most common genetic form of male hypogonadism. The majority (80-90\%) of patients have 47, XXY karyotype while mosaicism is seen in only 10-20\% of patients. Leg ulcers may be a presenting symptom of KS with a prevalence of 6-13\%. Treatment with testosterone has been reported to improve the ulcers.",

keywords = "Androgen therapy, Klinefelter syndrome, Leg ulcers, Mosaicism, Plasminogen activator inhibitor",

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AU - Kumar, Pratima

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N2 - Klinefelter syndrome (Ks) is the most common genetic form of male hypogonadism. The majority (80-90%) of patients have 47, XXY karyotype while mosaicism is seen in only 10-20% of patients. Leg ulcers may be a presenting symptom of KS with a prevalence of 6-13%. Treatment with testosterone has been reported to improve the ulcers.

AB - Klinefelter syndrome (Ks) is the most common genetic form of male hypogonadism. The majority (80-90%) of patients have 47, XXY karyotype while mosaicism is seen in only 10-20% of patients. Leg ulcers may be a presenting symptom of KS with a prevalence of 6-13%. Treatment with testosterone has been reported to improve the ulcers.

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KW - Leg ulcers

KW - Mosaicism

KW - Plasminogen activator inhibitor

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Improvement of venous leg ulcers with androgen replacement therapy in a patient with undiagnosed klinefelter syndrome

Abstract

Keywords

ASJC Scopus subject areas

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