Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids

Keyphrases

• Peptide Ligand 100%
• Glycine 100%
• Binding Affinity 100%
• D-amino Acids 100%
• Binding Stability 100%
• Urokinase-type Plasminogen Activator 40%
• Bicyclic Peptide 40%
• Inhibitory Activity 20%
• Amino Acids 20%
• Mutagenesis 20%
• Cancer-related 20%
• Protein Binding 20%
• Protease 20%
• Peptide Inhibitor 20%
• High Failure Rate 20%
• Dihedral Angle 20%
• Peptide Backbone 20%
• Backbone Conformation 20%
• Beneficial mutations 20%
• X-ray Structural Analysis 20%
• Mutation Type 20%
• Cyclic Peptide 20%
• Glycine Residue 20%
• Proteolytic Resistance 20%

Biochemistry, Genetics and Molecular Biology

• Binding Affinity 100%
• Amino Acids 100%
• Urokinase 50%
• X Ray 25%
• Mutagenesis 25%
• Conformation 25%
• Structure Analysis 25%
• Serine 25%
• Protease 25%
• Dihedral Angle 25%
• Cyclic Peptide 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Amino Acid 100%
• Urokinase 50%
• Malignant Neoplasm 25%
• Proteinase 25%
• Mutagenesis 25%
• Serine 25%
• Cyclopeptide 25%