Abstract
BACKGROUND: Brief periods of physical inactivity can compromise muscle health. Increasing dietary protein intake is potentially beneficial but complicated by difficulties reconciling anabolic potential with a realistic food volume and energy intake. We sought to determine whether increasing dietary protein quality could reduce the negative effects of physical inactivity. METHODS: Twenty healthy, older men and women completed 7 days of bed rest followed by 5 days of rehabilitation. Volunteers consumed a mixed macronutrient diet (MIXED: N = 10; 68 ± 2 years; 1,722 ± 29 kcal/day; 0.97 ± 0.01 g protein/kg/day) or an isoenergetic, whey-augmented, higher protein quality diet (WHEY: N = 10; 69 ± 1 years; 1,706 ± 23 kcal/day; 0.90 ± 0.01 g protein/kg/day). Outcomes included body composition, blood glucose, insulin, and a battery of physical function tests. RESULTS: During bed rest, both groups experienced a 20% reduction in knee extension peak torque (p < .05). The WHEY diet partially protected leg lean mass (-1,035 vs. -680 ± 138 g, MIXED vs. WHEY; p = .08) and contributed to a greater loss of body fat (-90 vs. -233 ± 152 g, MIXED vs. WHEY; p < .05). Following rehabilitation, knee extension peak torque in the WHEY group fully recovered (-10.0 vs. 2.2 ± 4.1 Nm, MIXED vs. WHEY; p = .05). Blood glucose, insulin, aerobic capacity, and Short Physical Performance Battery (SPPB) changes were similar in both dietary conditions (p > .05). CONCLUSIONS: Improving protein quality without increasing total energy intake has the potential to partially counter some of the negative effects of bed rest in older adults.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1605-1611 |
| Number of pages | 7 |
| Journal | The journals of gerontology. Series A, Biological sciences and medical sciences |
| Volume | 74 |
| Issue number | 10 |
| DOIs | |
| State | Published - Sep 15 2019 |
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Keywords
- Atrophy
- Bed rest
- Nutrition
- Whey protein
ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology
Cite this
Improving Dietary Protein Quality Reduces the Negative Effects of Physical Inactivity on Body Composition and Muscle Function. / Arentson-Lantz, Emily J.; Galvan, Elfego; Ellison, Jennifer; Wacher, Adam; Paddon-Jones, Douglas.
In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 74, No. 10, 15.09.2019, p. 1605-1611.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Improving Dietary Protein Quality Reduces the Negative Effects of Physical Inactivity on Body Composition and Muscle Function
AU - Arentson-Lantz, Emily J.
AU - Galvan, Elfego
AU - Ellison, Jennifer
AU - Wacher, Adam
AU - Paddon-Jones, Douglas
PY - 2019/9/15
Y1 - 2019/9/15
N2 - BACKGROUND: Brief periods of physical inactivity can compromise muscle health. Increasing dietary protein intake is potentially beneficial but complicated by difficulties reconciling anabolic potential with a realistic food volume and energy intake. We sought to determine whether increasing dietary protein quality could reduce the negative effects of physical inactivity. METHODS: Twenty healthy, older men and women completed 7 days of bed rest followed by 5 days of rehabilitation. Volunteers consumed a mixed macronutrient diet (MIXED: N = 10; 68 ± 2 years; 1,722 ± 29 kcal/day; 0.97 ± 0.01 g protein/kg/day) or an isoenergetic, whey-augmented, higher protein quality diet (WHEY: N = 10; 69 ± 1 years; 1,706 ± 23 kcal/day; 0.90 ± 0.01 g protein/kg/day). Outcomes included body composition, blood glucose, insulin, and a battery of physical function tests. RESULTS: During bed rest, both groups experienced a 20% reduction in knee extension peak torque (p < .05). The WHEY diet partially protected leg lean mass (-1,035 vs. -680 ± 138 g, MIXED vs. WHEY; p = .08) and contributed to a greater loss of body fat (-90 vs. -233 ± 152 g, MIXED vs. WHEY; p < .05). Following rehabilitation, knee extension peak torque in the WHEY group fully recovered (-10.0 vs. 2.2 ± 4.1 Nm, MIXED vs. WHEY; p = .05). Blood glucose, insulin, aerobic capacity, and Short Physical Performance Battery (SPPB) changes were similar in both dietary conditions (p > .05). CONCLUSIONS: Improving protein quality without increasing total energy intake has the potential to partially counter some of the negative effects of bed rest in older adults.
AB - BACKGROUND: Brief periods of physical inactivity can compromise muscle health. Increasing dietary protein intake is potentially beneficial but complicated by difficulties reconciling anabolic potential with a realistic food volume and energy intake. We sought to determine whether increasing dietary protein quality could reduce the negative effects of physical inactivity. METHODS: Twenty healthy, older men and women completed 7 days of bed rest followed by 5 days of rehabilitation. Volunteers consumed a mixed macronutrient diet (MIXED: N = 10; 68 ± 2 years; 1,722 ± 29 kcal/day; 0.97 ± 0.01 g protein/kg/day) or an isoenergetic, whey-augmented, higher protein quality diet (WHEY: N = 10; 69 ± 1 years; 1,706 ± 23 kcal/day; 0.90 ± 0.01 g protein/kg/day). Outcomes included body composition, blood glucose, insulin, and a battery of physical function tests. RESULTS: During bed rest, both groups experienced a 20% reduction in knee extension peak torque (p < .05). The WHEY diet partially protected leg lean mass (-1,035 vs. -680 ± 138 g, MIXED vs. WHEY; p = .08) and contributed to a greater loss of body fat (-90 vs. -233 ± 152 g, MIXED vs. WHEY; p < .05). Following rehabilitation, knee extension peak torque in the WHEY group fully recovered (-10.0 vs. 2.2 ± 4.1 Nm, MIXED vs. WHEY; p = .05). Blood glucose, insulin, aerobic capacity, and Short Physical Performance Battery (SPPB) changes were similar in both dietary conditions (p > .05). CONCLUSIONS: Improving protein quality without increasing total energy intake has the potential to partially counter some of the negative effects of bed rest in older adults.
KW - Atrophy
KW - Bed rest
KW - Nutrition
KW - Whey protein
UR - http://www.scopus.com/inward/record.url?scp=85062990953&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062990953&partnerID=8YFLogxK
U2 - 10.1093/gerona/glz003
DO - 10.1093/gerona/glz003
M3 - Article
C2 - 30689727
AN - SCOPUS:85062990953
VL - 74
SP - 1605
EP - 1611
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
SN - 1079-5006
IS - 10
ER -