In-hospital left ventricular thrombus following ST-elevation myocardial infarction

Aiham Albaeni, Khaled Chatila, Hind A. Beydoun, May A. Beydoun, Mohamed Morsy, Wissam Khalife

Research output: Contribution to journalArticle

Abstract

Background: In-hospital left ventricular (LV) thrombus following acute ST-elevation myocardial infarction (STEMI) has not been evaluated on a national scale and was the focus of this investigation. Methods: We used the 2003 to 2013 Nationwide Inpatient Sample database to identify adults ≥18 years old with a principal diagnosis code of ST-elevation myocardial infarction. Patients were divided into two groups defined by the presence or absence of LV thrombus. Clinical characteristics and in-hospital outcomes were studied using relevant statistics. Multiple linear and logistic regression models were conducted to identify factors associated with LV thrombus. Results: Of 1,035,888 STEMI patients hospitalized in the U. S from 2003 to 2013, 1982 (0.2%) developed acute in-hospital LV thrombus. Compared to no LV thrombus, patients with LV thrombus were more likely to have in-hospital complications; acute ischemic and hemorrhagic stroke, acute renal failure, gastrointestinal bleed, cardiogenic shock, in-hospital cardiac arrest and mortality. They also had longer mean length of stay and higher hospital charges. Factors associated with LV thrombus included: anterior/anterolateral STEMI, acute or chronic heart failure with reduced ejection fraction, atrial fibrillation, LV aneurysm, Left heart valvular disease, acute or chronic deep venous thrombosis/pulmonary embolism and alcohol abuse. Patients with LV thrombus were less likely to be female [AOR 0.66, 95% CI (0.51–0.84)]. Conclusion: The identification of factors associated with early development of LV thrombus following STEMI, will help direct resources for specific high-risk group and prompt cost-effective therapies. Gender variability in LV thrombus development warrants further investigations.

Original languageEnglish (US)
JournalInternational Journal of Cardiology
DOIs
StatePublished - Jan 1 2019

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Thrombosis
Logistic Models
Anterior Wall Myocardial Infarction
ST Elevation Myocardial Infarction
Hospital Charges
Heart Valve Diseases
Cardiogenic Shock
Heart Arrest
Pulmonary Embolism
Acute Kidney Injury
Venous Thrombosis
Atrial Fibrillation
Alcoholism
Aneurysm
Inpatients
Linear Models
Length of Stay
Heart Failure
Stroke
Databases

Keywords

  • Gender variation
  • In-hospital complications
  • Left ventricular thrombus
  • Resource utilization
  • ST-elevation myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

In-hospital left ventricular thrombus following ST-elevation myocardial infarction. / Albaeni, Aiham; Chatila, Khaled; Beydoun, Hind A.; Beydoun, May A.; Morsy, Mohamed; Khalife, Wissam.

In: International Journal of Cardiology, 01.01.2019.

Research output: Contribution to journalArticle

Albaeni, Aiham ; Chatila, Khaled ; Beydoun, Hind A. ; Beydoun, May A. ; Morsy, Mohamed ; Khalife, Wissam. / In-hospital left ventricular thrombus following ST-elevation myocardial infarction. In: International Journal of Cardiology. 2019.
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