TY - JOUR
T1 - In-human subject-specific evaluation of a control-theoretic plasma volume regulation model
AU - Bighamian, Ramin
AU - Kinsky, Michael
AU - Kramer, George
AU - Hahn, Jin Oh
N1 - Funding Information:
This work was supported by the Office of Naval Research under the Young Investigator Program Award [ ONR #N000141410591 , #N000141512018 ], University of Maryland under the Graduate Dean’s Dissertation Fellowship, American Heart Association under a Beginning Grant in Aid [ AHA #06650744 ], Foundation for Anesthesia Education and Research under a Mentored Research Training Grant [ FAER #58670 ], National Center for Research Resources , National Institutes of Health under a Clinical Translational Science Award [ NIH #UL1TR000071 ], and the Institute for Translational Science-Clinical Research Center (ITS-CRC) at the University of Texas Medical Branch (UTMB) at Galveston, TX. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the ONR, AHA, FAER, NIH, and UTMB.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/12/1
Y1 - 2017/12/1
N2 - The goal of this study was to conduct a subject-specific evaluation of a control-theoretic plasma volume regulation model in humans. We employed a set of clinical data collected from nine human subjects receiving fluid bolus with and without co-administration of an inotrope agent, including fluid infusion rate, plasma volume, and urine output. Once fitted to the data associated with each subject, the model accurately reproduced the fractional plasma volume change responses in all subjects: the error between actual versus model-reproduced fractional plasma volume change responses was only 1.4 ± 1.6% and 1.2 ± 0.3% of the average fractional plasma volume change responses in the absence and presence of inotrope co-administration. In addition, the model parameters determined by the subject-specific fitting assumed physiologically plausible values: (i) initial plasma volume was estimated to be 36 ± 11 mL/kg and 37 ± 10 mL/kg in the absence and presence of inotrope infusion, respectively, which was comparable to its actual counterpart of 37 ± 4 mL/kg and 43 ± 6 mL/kg; (ii) volume distribution ratio, specifying the ratio with which the inputted fluid is distributed in the intra- and extra-vascular spaces, was estimated to be 3.5 ± 2.4 and 1.9 ± 0.5 in the absence and presence of inotrope infusion, respectively, which accorded with the experimental observation that inotrope could enhance plasma volume expansion in response to fluid infusion. We concluded that the model was equipped with the ability to reproduce plasma volume response to fluid infusion in humans with physiologically plausible model parameters, and its validity may persist even under co-administration of inotropic agents.
AB - The goal of this study was to conduct a subject-specific evaluation of a control-theoretic plasma volume regulation model in humans. We employed a set of clinical data collected from nine human subjects receiving fluid bolus with and without co-administration of an inotrope agent, including fluid infusion rate, plasma volume, and urine output. Once fitted to the data associated with each subject, the model accurately reproduced the fractional plasma volume change responses in all subjects: the error between actual versus model-reproduced fractional plasma volume change responses was only 1.4 ± 1.6% and 1.2 ± 0.3% of the average fractional plasma volume change responses in the absence and presence of inotrope co-administration. In addition, the model parameters determined by the subject-specific fitting assumed physiologically plausible values: (i) initial plasma volume was estimated to be 36 ± 11 mL/kg and 37 ± 10 mL/kg in the absence and presence of inotrope infusion, respectively, which was comparable to its actual counterpart of 37 ± 4 mL/kg and 43 ± 6 mL/kg; (ii) volume distribution ratio, specifying the ratio with which the inputted fluid is distributed in the intra- and extra-vascular spaces, was estimated to be 3.5 ± 2.4 and 1.9 ± 0.5 in the absence and presence of inotrope infusion, respectively, which accorded with the experimental observation that inotrope could enhance plasma volume expansion in response to fluid infusion. We concluded that the model was equipped with the ability to reproduce plasma volume response to fluid infusion in humans with physiologically plausible model parameters, and its validity may persist even under co-administration of inotropic agents.
KW - Blood volume
KW - Circulatory resuscitation
KW - Control-theoretic model
KW - In-silico evaluation
KW - Mathematical model
KW - Physiological closed-loop control
KW - Physiological model
KW - Plasma volume
KW - Pre-clinical evaluation
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U2 - 10.1016/j.compbiomed.2017.10.006
DO - 10.1016/j.compbiomed.2017.10.006
M3 - Article
C2 - 29049911
AN - SCOPUS:85031736267
SN - 0010-4825
VL - 91
SP - 96
EP - 102
JO - Computers in Biology and Medicine
JF - Computers in Biology and Medicine
ER -