In silico analysis suggests repurposing of ibuprofen for prevention and treatment of EBOLA virus disease

Veljko Veljkovic, Marco Goeijenbier, Sanja Glisic, Nevena Veljkovic, Vladimir R. Perovic, Milan Sencanski, Donald R. Branch, Slobodan Paessler

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The large 2014/2015 Ebola virus outbreak in West Africa points out the urgent need to develop new preventive and therapeutic approaches that are effective against Ebola viruses and can be rapidly utilized. Recently, a simple theoretical criterion for the virtual screening of molecular libraries for candidate inhibitors of Ebola virus infection was proposed. Using this method the 'drug space' was screened and 267 approved and 382 experimental drugs as candidates for treatment of the Ebola virus disease (EVD) have been selected. Detailed analysis of these drugs revealed the non-steroidal anti-inflammatory drug ibuprofen as an inexpensive, widely accessible and minimally toxic candidate for prevention and treatment of EVD. Furthermore, the molecular mechanism underlying this possible protective effect of ibuprofen against EVD is suggested in this article.

Original languageEnglish (US)
Article number104
JournalF1000Research
Volume4
DOIs
StatePublished - May 1 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Veljkovic, V., Goeijenbier, M., Glisic, S., Veljkovic, N., Perovic, V. R., Sencanski, M., Branch, D. R., & Paessler, S. (2015). In silico analysis suggests repurposing of ibuprofen for prevention and treatment of EBOLA virus disease. F1000Research, 4, [104]. https://doi.org/10.12688/f1000research.6436.1