In vitro alterations in human fibroblast behavior secondary to silicone polymers

Robert L. McCauley, William B. Riley, Rudolph A. Juliano, Patricia Brown, Michael J. Evans, Martin C. Robson

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    The etiology of fibrous capsular contractures in patients with silicone prostheses is unclear. However, cellular responses to the silicone polymers of the prostheses have not been examined. The exposure of human dermal fibroblasts to the components of the silicone gel prosthesis results in a significant change in cellular configuration and a progressive reduction in cell proliferation as determined by total matrix protein assays and hemocytometer cell counts. Transmission electron microscopy, however, documents a twofold increase in the rough endoplasmic reticulum when cells are exposed to the silicone gel. These findings suggest significant alterations in the behavior of human fibroblast subpopulations in response to silicone polymers.

    Original languageEnglish (US)
    Pages (from-to)103-109
    Number of pages7
    JournalJournal of Surgical Research
    Volume49
    Issue number1
    DOIs
    StatePublished - 1990

    Fingerprint

    Silicones
    Silicone Gels
    Prostheses and Implants
    Polymers
    Fibroblasts
    Rough Endoplasmic Reticulum
    Contracture
    Transmission Electron Microscopy
    Cell Count
    Cell Proliferation
    Skin
    In Vitro Techniques
    Proteins

    ASJC Scopus subject areas

    • Surgery

    Cite this

    McCauley, R. L., Riley, W. B., Juliano, R. A., Brown, P., Evans, M. J., & Robson, M. C. (1990). In vitro alterations in human fibroblast behavior secondary to silicone polymers. Journal of Surgical Research, 49(1), 103-109. https://doi.org/10.1016/0022-4804(90)90118-L

    In vitro alterations in human fibroblast behavior secondary to silicone polymers. / McCauley, Robert L.; Riley, William B.; Juliano, Rudolph A.; Brown, Patricia; Evans, Michael J.; Robson, Martin C.

    In: Journal of Surgical Research, Vol. 49, No. 1, 1990, p. 103-109.

    Research output: Contribution to journalArticle

    McCauley, RL, Riley, WB, Juliano, RA, Brown, P, Evans, MJ & Robson, MC 1990, 'In vitro alterations in human fibroblast behavior secondary to silicone polymers', Journal of Surgical Research, vol. 49, no. 1, pp. 103-109. https://doi.org/10.1016/0022-4804(90)90118-L
    McCauley, Robert L. ; Riley, William B. ; Juliano, Rudolph A. ; Brown, Patricia ; Evans, Michael J. ; Robson, Martin C. / In vitro alterations in human fibroblast behavior secondary to silicone polymers. In: Journal of Surgical Research. 1990 ; Vol. 49, No. 1. pp. 103-109.
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