In vitro alterations in human fibroblast behavior secondary to silicone polymers

Robert L. McCauley, William B. Riley, Rudolph A. Juliano, Patricia Brown, Michael J. Evans, Martin C. Robson

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The etiology of fibrous capsular contractures in patients with silicone prostheses is unclear. However, cellular responses to the silicone polymers of the prostheses have not been examined. The exposure of human dermal fibroblasts to the components of the silicone gel prosthesis results in a significant change in cellular configuration and a progressive reduction in cell proliferation as determined by total matrix protein assays and hemocytometer cell counts. Transmission electron microscopy, however, documents a twofold increase in the rough endoplasmic reticulum when cells are exposed to the silicone gel. These findings suggest significant alterations in the behavior of human fibroblast subpopulations in response to silicone polymers.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalJournal of Surgical Research
Volume49
Issue number1
DOIs
StatePublished - Jul 1990

ASJC Scopus subject areas

  • Surgery

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    McCauley, R. L., Riley, W. B., Juliano, R. A., Brown, P., Evans, M. J., & Robson, M. C. (1990). In vitro alterations in human fibroblast behavior secondary to silicone polymers. Journal of Surgical Research, 49(1), 103-109. https://doi.org/10.1016/0022-4804(90)90118-L