In vitro alterations in human fibroblast behavior secondary to silicone polymers

Robert L. McCauley, William B. Riley, Rudolph A. Juliano, Patricia Brown, Michael J. Evans, Martin C. Robson

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    Abstract

    The etiology of fibrous capsular contractures in patients with silicone prostheses is unclear. However, cellular responses to the silicone polymers of the prostheses have not been examined. The exposure of human dermal fibroblasts to the components of the silicone gel prosthesis results in a significant change in cellular configuration and a progressive reduction in cell proliferation as determined by total matrix protein assays and hemocytometer cell counts. Transmission electron microscopy, however, documents a twofold increase in the rough endoplasmic reticulum when cells are exposed to the silicone gel. These findings suggest significant alterations in the behavior of human fibroblast subpopulations in response to silicone polymers.

    Original languageEnglish (US)
    Pages (from-to)103-109
    Number of pages7
    JournalJournal of Surgical Research
    Volume49
    Issue number1
    DOIs
    StatePublished - 1990

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    ASJC Scopus subject areas

    • Surgery

    Cite this

    McCauley, R. L., Riley, W. B., Juliano, R. A., Brown, P., Evans, M. J., & Robson, M. C. (1990). In vitro alterations in human fibroblast behavior secondary to silicone polymers. Journal of Surgical Research, 49(1), 103-109. https://doi.org/10.1016/0022-4804(90)90118-L