In Vitro and in Vivo Activity of Amiodarone Against Ebola Virus

Julie Dyall; Joshua C. Johnson; Brit J. Hart; Elena Postnikova; Yu Cong; Huanying Zhou; Dawn M. Gerhardt; Julia Michelotti; Anna N. Honko; Steven Kern; Lisa Evans Dewald; Kathleen G. O'Loughlin; Carol E. Green; Jon C. Mirsalis; Richard S. Bennett; Gene G. Olinger; Peter B. Jahrling; Lisa E. Hensley

doi:10.1093/infdis/jiy345

In Vitro and in Vivo Activity of Amiodarone Against Ebola Virus

Julie Dyall, Joshua C. Johnson, Brit J. Hart, Elena Postnikova, Yu Cong, Huanying Zhou, Dawn M. Gerhardt, Julia Michelotti, Anna N. Honko, Steven Kern, Lisa Evans Dewald, Kathleen G. O'Loughlin, Carol E. Green, Jon C. Mirsalis, Richard S. Bennett, Gene G. Olinger, Peter B. Jahrling, Lisa E. Hensley

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

At the onset of the 2013-2016 epidemic of Ebola virus disease (EVD), no vaccine or antiviral medication was approved for treatment. Therefore, considerable efforts were directed towards the concept of drug repurposing or repositioning. Amiodarone, an approved multi-ion channel blocker for the treatment of cardiac arrhythmia, was reported to inhibit filovirus entry in vitro. Compassionate use of amiodarone in EVD patients indicated a possible survival benefit. In support of further clinical testing, we confirmed anti-Ebola virus activity of amiodarone in different cell types. Despite promising in vitro results, amiodarone failed to protect Guinea pigs from a lethal dose of Ebola virus.

Original language	English (US)
Pages (from-to)	S592-S596
Journal	Journal of Infectious Diseases
Volume	218
DOIs	https://doi.org/10.1093/infdis/jiy345
State	Published - Nov 22 2018
Externally published	Yes

Keywords

amiodarone
antiviral
Ebola virus.

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jiy345

Cite this

Dyall, J., Johnson, J. C., Hart, B. J., Postnikova, E., Cong, Y., Zhou, H., Gerhardt, D. M., Michelotti, J., Honko, A. N., Kern, S., Dewald, L. E., O'Loughlin, K. G., Green, C. E., Mirsalis, J. C., Bennett, R. S., Olinger, G. G., Jahrling, P. B., & Hensley, L. E. (2018). In Vitro and in Vivo Activity of Amiodarone Against Ebola Virus. Journal of Infectious Diseases, 218, S592-S596. https://doi.org/10.1093/infdis/jiy345

Dyall, J, Johnson, JC, Hart, BJ, Postnikova, E, Cong, Y, Zhou, H, Gerhardt, DM, Michelotti, J, Honko, AN, Kern, S, Dewald, LE, O'Loughlin, KG, Green, CE, Mirsalis, JC, Bennett, RS, Olinger, GG, Jahrling, PB & Hensley, LE 2018, 'In Vitro and in Vivo Activity of Amiodarone Against Ebola Virus', Journal of Infectious Diseases, vol. 218, pp. S592-S596. https://doi.org/10.1093/infdis/jiy345

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abstract = "At the onset of the 2013-2016 epidemic of Ebola virus disease (EVD), no vaccine or antiviral medication was approved for treatment. Therefore, considerable efforts were directed towards the concept of drug repurposing or repositioning. Amiodarone, an approved multi-ion channel blocker for the treatment of cardiac arrhythmia, was reported to inhibit filovirus entry in vitro. Compassionate use of amiodarone in EVD patients indicated a possible survival benefit. In support of further clinical testing, we confirmed anti-Ebola virus activity of amiodarone in different cell types. Despite promising in vitro results, amiodarone failed to protect Guinea pigs from a lethal dose of Ebola virus.",

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In Vitro and in Vivo Activity of Amiodarone Against Ebola Virus

Abstract

Keywords

ASJC Scopus subject areas

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