Abstract
Seven triterpenoids namely, ursolic acid (1) cis-3-O-p-hydroxycinnamoyl ursolic acid (2), trans-3-O-p-hydroxycinnamoyl ursolic acid (3), oleanolic acid (4), corosolic acid (5), maslinic acid (6) and β-amyrin (7) were isolated from the leaves of Saurauia roxburghii based on spectroscopic indication. Compounds 2, 3 and 4 were isolated from this plant for the first time. The LC50 for crude ethanol, n-hexane, chloroform, ethyl-acetate; column fractions H-13 of the crude n-hexane, C-19 of the crude chloroform and three pure compounds 1, 3 and 4 were found to be 12.59, 14.79, 14.06, 11.75, 10.96, 4.37, 6.92 and 11.88 μg mLG1, respectively. The crude ethanol extract exhibited good; n-hexane, chloroform, ethyl-acetate extracts exhibited moderate; five column fractions (H-13, C-15, C-19, E-18 and E-24) exhibited low to mild and three pure compounds (1, 3 and 4) presented moderate antibacterial activity against maximum of the tested bacteria.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 821-827 |
| Number of pages | 7 |
| Journal | International Journal of Pharmacology |
| Volume | 11 |
| Issue number | 7 |
| DOIs | |
| State | Published - Aug 28 2015 |
| Externally published | Yes |
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Keywords
- Antimicrobial and cytotoxic activity
- Cis-3-O-p-hydroxycinnamoyl ursolic acid
- Oleanolic acid
- Trans-3-O-phydroxy- cinnamoyl ursolic acid
- Triterpenoids
ASJC Scopus subject areas
- Pharmacology
Cite this
In vitro antibacterial and in vivo brine shrimp lethal active compounds isolated from the leaves of Saurauia roxburghii. / Ahmed, Yunus; Yaakob, Zahira; Akhtar, Parul; Rahman, Mahbubur; Islam, Faridul.
In: International Journal of Pharmacology, Vol. 11, No. 7, 28.08.2015, p. 821-827.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro antibacterial and in vivo brine shrimp lethal active compounds isolated from the leaves of Saurauia roxburghii
AU - Ahmed, Yunus
AU - Yaakob, Zahira
AU - Akhtar, Parul
AU - Rahman, Mahbubur
AU - Islam, Faridul
PY - 2015/8/28
Y1 - 2015/8/28
N2 - Seven triterpenoids namely, ursolic acid (1) cis-3-O-p-hydroxycinnamoyl ursolic acid (2), trans-3-O-p-hydroxycinnamoyl ursolic acid (3), oleanolic acid (4), corosolic acid (5), maslinic acid (6) and β-amyrin (7) were isolated from the leaves of Saurauia roxburghii based on spectroscopic indication. Compounds 2, 3 and 4 were isolated from this plant for the first time. The LC50 for crude ethanol, n-hexane, chloroform, ethyl-acetate; column fractions H-13 of the crude n-hexane, C-19 of the crude chloroform and three pure compounds 1, 3 and 4 were found to be 12.59, 14.79, 14.06, 11.75, 10.96, 4.37, 6.92 and 11.88 μg mLG1, respectively. The crude ethanol extract exhibited good; n-hexane, chloroform, ethyl-acetate extracts exhibited moderate; five column fractions (H-13, C-15, C-19, E-18 and E-24) exhibited low to mild and three pure compounds (1, 3 and 4) presented moderate antibacterial activity against maximum of the tested bacteria.
AB - Seven triterpenoids namely, ursolic acid (1) cis-3-O-p-hydroxycinnamoyl ursolic acid (2), trans-3-O-p-hydroxycinnamoyl ursolic acid (3), oleanolic acid (4), corosolic acid (5), maslinic acid (6) and β-amyrin (7) were isolated from the leaves of Saurauia roxburghii based on spectroscopic indication. Compounds 2, 3 and 4 were isolated from this plant for the first time. The LC50 for crude ethanol, n-hexane, chloroform, ethyl-acetate; column fractions H-13 of the crude n-hexane, C-19 of the crude chloroform and three pure compounds 1, 3 and 4 were found to be 12.59, 14.79, 14.06, 11.75, 10.96, 4.37, 6.92 and 11.88 μg mLG1, respectively. The crude ethanol extract exhibited good; n-hexane, chloroform, ethyl-acetate extracts exhibited moderate; five column fractions (H-13, C-15, C-19, E-18 and E-24) exhibited low to mild and three pure compounds (1, 3 and 4) presented moderate antibacterial activity against maximum of the tested bacteria.
KW - Antimicrobial and cytotoxic activity
KW - Cis-3-O-p-hydroxycinnamoyl ursolic acid
KW - Oleanolic acid
KW - Trans-3-O-phydroxy- cinnamoyl ursolic acid
KW - Triterpenoids
UR - http://www.scopus.com/inward/record.url?scp=84942083997&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942083997&partnerID=8YFLogxK
U2 - 10.3923/ijp.2015.821.827
DO - 10.3923/ijp.2015.821.827
M3 - Article
AN - SCOPUS:84942083997
VL - 11
SP - 821
EP - 827
JO - International Journal of Pharmacology
JF - International Journal of Pharmacology
SN - 1811-7775
IS - 7
ER -