Abstract
Seven triterpenoids namely, ursolic acid (1) cis-3-O-p-hydroxycinnamoyl ursolic acid (2), trans-3-O-p-hydroxycinnamoyl ursolic acid (3), oleanolic acid (4), corosolic acid (5), maslinic acid (6) and β-amyrin (7) were isolated from the leaves of Saurauia roxburghii based on spectroscopic indication. Compounds 2, 3 and 4 were isolated from this plant for the first time. The LC50 for crude ethanol, n-hexane, chloroform, ethyl-acetate; column fractions H-13 of the crude n-hexane, C-19 of the crude chloroform and three pure compounds 1, 3 and 4 were found to be 12.59, 14.79, 14.06, 11.75, 10.96, 4.37, 6.92 and 11.88 μg mLG1, respectively. The crude ethanol extract exhibited good; n-hexane, chloroform, ethyl-acetate extracts exhibited moderate; five column fractions (H-13, C-15, C-19, E-18 and E-24) exhibited low to mild and three pure compounds (1, 3 and 4) presented moderate antibacterial activity against maximum of the tested bacteria.
Original language | English (US) |
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Pages (from-to) | 821-827 |
Number of pages | 7 |
Journal | International Journal of Pharmacology |
Volume | 11 |
Issue number | 7 |
DOIs | |
State | Published - Aug 28 2015 |
Externally published | Yes |
Keywords
- Antimicrobial and cytotoxic activity
- Cis-3-O-p-hydroxycinnamoyl ursolic acid
- Oleanolic acid
- Trans-3-O-phydroxy- cinnamoyl ursolic acid
- Triterpenoids
ASJC Scopus subject areas
- Pharmacology