In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses

Michael K. Lo, Pei-Yong Shi, Yen Liang Chen, Mike Flint, Christina F. Spiropoulou

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study, we describe the in vitro antiviral activity of adenosine analog NITD008 against KFDV, AHFV, OHFV, as well as Tick-borne Encephalitis virus (TBEV). Alongside the well-established activity of NITD008 against mosquito-borne flaviviruses, our results have demonstrated the feasibility of identifying nucleoside analog inhibitors that have pan-flavivirus activity.

Original languageEnglish (US)
Pages (from-to)46-49
Number of pages4
JournalAntiviral Research
Volume130
DOIs
StatePublished - Jun 1 2016

Fingerprint

Tick-Borne Encephalitis Viruses
Flavivirus
Ticks
Adenosine
Antiviral Agents
In Vitro Techniques
NITD008
Culicidae
Nucleosides
Fever

Keywords

  • Antiviral
  • Flavivirus
  • NITD008
  • Nucleoside analog
  • Tick-borne

ASJC Scopus subject areas

  • Virology
  • Pharmacology

Cite this

In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. / Lo, Michael K.; Shi, Pei-Yong; Chen, Yen Liang; Flint, Mike; Spiropoulou, Christina F.

In: Antiviral Research, Vol. 130, 01.06.2016, p. 46-49.

Research output: Contribution to journalArticle

Lo, Michael K. ; Shi, Pei-Yong ; Chen, Yen Liang ; Flint, Mike ; Spiropoulou, Christina F. / In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. In: Antiviral Research. 2016 ; Vol. 130. pp. 46-49.
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