In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses

Michael K. Lo; Pei Yong Shi; Yen Liang Chen; Mike Flint; Christina F. Spiropoulou

doi:10.1016/j.antiviral.2016.03.013

In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses

Michael K. Lo, Pei Yong Shi, Yen Liang Chen, Mike Flint, Christina F. Spiropoulou

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study, we describe the in vitro antiviral activity of adenosine analog NITD008 against KFDV, AHFV, OHFV, as well as Tick-borne Encephalitis virus (TBEV). Alongside the well-established activity of NITD008 against mosquito-borne flaviviruses, our results have demonstrated the feasibility of identifying nucleoside analog inhibitors that have pan-flavivirus activity.

Original language	English (US)
Pages (from-to)	46-49
Number of pages	4
Journal	Antiviral research
Volume	130
DOIs	https://doi.org/10.1016/j.antiviral.2016.03.013
State	Published - Jun 1 2016

Keywords

Antiviral
Flavivirus
NITD008
Nucleoside analog
Tick-borne

ASJC Scopus subject areas

Pharmacology
Virology

Access to Document

10.1016/j.antiviral.2016.03.013

Cite this

@article{83e617cd27244436ad42dee7cf1ebc28,

title = "In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses",

abstract = "There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study, we describe the in vitro antiviral activity of adenosine analog NITD008 against KFDV, AHFV, OHFV, as well as Tick-borne Encephalitis virus (TBEV). Alongside the well-established activity of NITD008 against mosquito-borne flaviviruses, our results have demonstrated the feasibility of identifying nucleoside analog inhibitors that have pan-flavivirus activity.",

keywords = "Antiviral, Flavivirus, NITD008, Nucleoside analog, Tick-borne",

author = "Lo, {Michael K.} and Shi, {Pei Yong} and Chen, {Yen Liang} and Mike Flint and Spiropoulou, {Christina F.}",

note = "Funding Information: The findings and conclusions in this report are those of the authors and do not necessarily represent those of the Centers for Disease Control and Prevention. This work was financially supported by CDC core funding .",

year = "2016",

month = jun,

day = "1",

doi = "10.1016/j.antiviral.2016.03.013",

language = "English (US)",

volume = "130",

pages = "46--49",

journal = "Antiviral research",

issn = "0166-3542",

publisher = "Elsevier",

}

TY - JOUR

T1 - In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses

AU - Lo, Michael K.

AU - Shi, Pei Yong

AU - Chen, Yen Liang

AU - Flint, Mike

AU - Spiropoulou, Christina F.

N1 - Funding Information: The findings and conclusions in this report are those of the authors and do not necessarily represent those of the Centers for Disease Control and Prevention. This work was financially supported by CDC core funding .

PY - 2016/6/1

Y1 - 2016/6/1

N2 - There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study, we describe the in vitro antiviral activity of adenosine analog NITD008 against KFDV, AHFV, OHFV, as well as Tick-borne Encephalitis virus (TBEV). Alongside the well-established activity of NITD008 against mosquito-borne flaviviruses, our results have demonstrated the feasibility of identifying nucleoside analog inhibitors that have pan-flavivirus activity.

AB - There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study, we describe the in vitro antiviral activity of adenosine analog NITD008 against KFDV, AHFV, OHFV, as well as Tick-borne Encephalitis virus (TBEV). Alongside the well-established activity of NITD008 against mosquito-borne flaviviruses, our results have demonstrated the feasibility of identifying nucleoside analog inhibitors that have pan-flavivirus activity.

KW - Antiviral

KW - Flavivirus

KW - NITD008

KW - Nucleoside analog

KW - Tick-borne

UR - http://www.scopus.com/inward/record.url?scp=84961960658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961960658&partnerID=8YFLogxK

U2 - 10.1016/j.antiviral.2016.03.013

DO - 10.1016/j.antiviral.2016.03.013

M3 - Article

C2 - 27016316

AN - SCOPUS:84961960658

SN - 0166-3542

VL - 130

SP - 46

EP - 49

JO - Antiviral research

JF - Antiviral research

ER -

In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this