@article{1049470510814aa780d0247c388b0169,
title = "In Vitro Characterization and in Vivo Effectiveness of Ebola Virus Specific Equine Polyclonal F(ab′)2",
abstract = "There is no vaccine or approved therapy against lethal Ebola virus (EBOV). We investigated a proven technology platform to produce polyclonal IgG fragments, F(ab′)2, against EBOV. Horses immunized with nanoparticles harboring surface glycoprotein trimers of EBOV-Zaire/Makona produced anti-Ebola IgG polyclonal antibodies with high neutralization activity. Highly purified equine anti-Ebola F(ab′)2 showed strong cross-neutralization of 2 Zaire EBOV strains (Gabon 2001 and Makona) and in vivo 3 or 5 daily F(ab′)2 intraperitoneal injections provided 100% protection to BALB/c mice against lethal EBOV challenge. Rapid preparation of purified equine anti-Ebola F(ab′)2 offers a potentially efficient therapeutic approach against EBOV disease in humans.",
keywords = "Ebola, F(ab′) fragments, equine, immunoglobulins",
author = "Trina Racine and M{\'e}lanie Denizot and Delphine Pannetier and Ludovic Nguyen and Ana{\"i}s Pasquier and Herv{\'e} Raoul and Saluzzo, {Jean Fran{\c c}ois} and Gary Kobinger and Francisco Veas and Herbreteau, {C{\'e}cile H.}",
note = "Funding Information: Financial support. This work was supported by the European Commission within the H2020 framework in the context of the Global IF-EBOLA European-US project (grant number 666102); the french Public Bank for Investment (BPI) within the industrial strategic innovation program (EMER-IT project), and by the study sponsor, Fab{\textquoteright}entech. Potential conflicts of interest. M. D., L. N., A. P., and C. H. H. are full-time employees of Fab{\textquoteright}entech and J. F. S. works as external consultant for Fab{\textquoteright}entech. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. Publisher Copyright: {\textcopyright} 2019 The Author(s) 2019.",
year = "2019",
month = jun,
day = "5",
doi = "10.1093/infdis/jiz068",
language = "English (US)",
volume = "220",
pages = "41--45",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",
}