In vitro comparison of four tocolytic agents, alone and in combination

George Saade, O. Taskin, M. A. Belfort, B. Erturan, K. J. Moise

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: To compare the tocolytic effects of magnesium sulfate, ritodrine, terbutaline, and nifedipine on human myometrial strips. Methods: Myometrial strips were suspended in organ chambers for isotonic measurements and contracted with KCl. Strips from nonpregnant patients were used to obtain concentration-response curves. Myometrial strips from pregnant uteri were then exposed to the molar concentrations causing 50% relaxation in the nonpregnant tissues. Results: In strips from nonpregnant patients, nifedipine was found to be the most potent tocolytic. Using strips from nonlaboring patients, nifedipine caused relaxation similar to ritodrine, and both were more effective than magnesium sulfate or terbutaline. Combinations were more effective than single agents. These agents were found to be equally less effective in myometrial strips from laboring patients. Conclusions: Nifedipine, alone or in combination, relaxes myometrial strips more effectively than the other agents studied. Myometrial strips from laboring patients are more resistant to inhibition, with none of the agents being superior.

Original languageEnglish (US)
Pages (from-to)374-378
Number of pages5
JournalObstetrics and Gynecology
Volume84
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

Tocolytic Agents
Nifedipine
Ritodrine
Terbutaline
Magnesium Sulfate
Uterus
In Vitro Techniques

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Saade, G., Taskin, O., Belfort, M. A., Erturan, B., & Moise, K. J. (1994). In vitro comparison of four tocolytic agents, alone and in combination. Obstetrics and Gynecology, 84(3), 374-378.

In vitro comparison of four tocolytic agents, alone and in combination. / Saade, George; Taskin, O.; Belfort, M. A.; Erturan, B.; Moise, K. J.

In: Obstetrics and Gynecology, Vol. 84, No. 3, 1994, p. 374-378.

Research output: Contribution to journalArticle

Saade, G, Taskin, O, Belfort, MA, Erturan, B & Moise, KJ 1994, 'In vitro comparison of four tocolytic agents, alone and in combination', Obstetrics and Gynecology, vol. 84, no. 3, pp. 374-378.
Saade G, Taskin O, Belfort MA, Erturan B, Moise KJ. In vitro comparison of four tocolytic agents, alone and in combination. Obstetrics and Gynecology. 1994;84(3):374-378.
Saade, George ; Taskin, O. ; Belfort, M. A. ; Erturan, B. ; Moise, K. J. / In vitro comparison of four tocolytic agents, alone and in combination. In: Obstetrics and Gynecology. 1994 ; Vol. 84, No. 3. pp. 374-378.
@article{5ea54891dd424847b04145fac1f27f3e,
title = "In vitro comparison of four tocolytic agents, alone and in combination",
abstract = "Objective: To compare the tocolytic effects of magnesium sulfate, ritodrine, terbutaline, and nifedipine on human myometrial strips. Methods: Myometrial strips were suspended in organ chambers for isotonic measurements and contracted with KCl. Strips from nonpregnant patients were used to obtain concentration-response curves. Myometrial strips from pregnant uteri were then exposed to the molar concentrations causing 50{\%} relaxation in the nonpregnant tissues. Results: In strips from nonpregnant patients, nifedipine was found to be the most potent tocolytic. Using strips from nonlaboring patients, nifedipine caused relaxation similar to ritodrine, and both were more effective than magnesium sulfate or terbutaline. Combinations were more effective than single agents. These agents were found to be equally less effective in myometrial strips from laboring patients. Conclusions: Nifedipine, alone or in combination, relaxes myometrial strips more effectively than the other agents studied. Myometrial strips from laboring patients are more resistant to inhibition, with none of the agents being superior.",
author = "George Saade and O. Taskin and Belfort, {M. A.} and B. Erturan and Moise, {K. J.}",
year = "1994",
language = "English (US)",
volume = "84",
pages = "374--378",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - In vitro comparison of four tocolytic agents, alone and in combination

AU - Saade, George

AU - Taskin, O.

AU - Belfort, M. A.

AU - Erturan, B.

AU - Moise, K. J.

PY - 1994

Y1 - 1994

N2 - Objective: To compare the tocolytic effects of magnesium sulfate, ritodrine, terbutaline, and nifedipine on human myometrial strips. Methods: Myometrial strips were suspended in organ chambers for isotonic measurements and contracted with KCl. Strips from nonpregnant patients were used to obtain concentration-response curves. Myometrial strips from pregnant uteri were then exposed to the molar concentrations causing 50% relaxation in the nonpregnant tissues. Results: In strips from nonpregnant patients, nifedipine was found to be the most potent tocolytic. Using strips from nonlaboring patients, nifedipine caused relaxation similar to ritodrine, and both were more effective than magnesium sulfate or terbutaline. Combinations were more effective than single agents. These agents were found to be equally less effective in myometrial strips from laboring patients. Conclusions: Nifedipine, alone or in combination, relaxes myometrial strips more effectively than the other agents studied. Myometrial strips from laboring patients are more resistant to inhibition, with none of the agents being superior.

AB - Objective: To compare the tocolytic effects of magnesium sulfate, ritodrine, terbutaline, and nifedipine on human myometrial strips. Methods: Myometrial strips were suspended in organ chambers for isotonic measurements and contracted with KCl. Strips from nonpregnant patients were used to obtain concentration-response curves. Myometrial strips from pregnant uteri were then exposed to the molar concentrations causing 50% relaxation in the nonpregnant tissues. Results: In strips from nonpregnant patients, nifedipine was found to be the most potent tocolytic. Using strips from nonlaboring patients, nifedipine caused relaxation similar to ritodrine, and both were more effective than magnesium sulfate or terbutaline. Combinations were more effective than single agents. These agents were found to be equally less effective in myometrial strips from laboring patients. Conclusions: Nifedipine, alone or in combination, relaxes myometrial strips more effectively than the other agents studied. Myometrial strips from laboring patients are more resistant to inhibition, with none of the agents being superior.

UR - http://www.scopus.com/inward/record.url?scp=0028095011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028095011&partnerID=8YFLogxK

M3 - Article

VL - 84

SP - 374

EP - 378

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 3

ER -