In vitro evidence for increased cellular immunity to lung cancer antigen during Levamisole immunotherapy

M. M. Urist, A. W. Boddie, C. M. Townsend, E. C. Holmes

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Levamisole, a potentiator of cell-mediated immunity, has been reported to increase survival in patients with resectable carcinoma of the lung. Cell-mediated immunity can be measured in vitro by the leukocyte migration inhibition test. We have previously reported that this test detects cell-mediated immunity to human lung tumor antigens. In the present studies, patients with lung cancer were treated with Levamisole. Their leukocytes were evaluated in the leukocyte migration inhibition assay before, during, and following Levamisole therapy. Small increases in cell-mediated immunity were observed when patients had a high pre-existing tumor immunity. When tumor-associated reactivity was absent prior to therapy, larger increases were measured. Although Levamisole is a nonspecific immunostimulant, these data indicate that in vitro anti-tumor immune responses are enhanced by Levamisole therapy. Augmentation of cell-mediated immunity to tumor antigens may explain the clinical benefits of Levamisole therapy.

Original languageEnglish (US)
Pages (from-to)189-194
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume73
Issue number2
DOIs
StatePublished - 1977

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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