TY - JOUR
T1 - In vitro inactivation of plasma α1-proteinase inhibitor by epoxides and 1,2-dihaloethanes
AU - Ansari, G. A.S.
AU - Gan, Jose C.
AU - Barton, Brian K.
PY - 1988/7/1
Y1 - 1988/7/1
N2 - The inactivating effects of three epoxides and two dihaloethanes on the proteinase inhibitory activities of α1-proteinase inhibitor, as well as those of the plasma itself, were investigated. All of the three epoxides (styrene oxide, ethylene oxide and propylene oxide), individually, inactivated the elastase inhibitory or trypsin inhibitory activity of proteinase inhibitor, and that of whole plasma. Styrene oxide is the most effective inactivator of either purified α1-proteinase inhibitor or plasma, followed by ethylene oxide and propylene oxide in a decreasing order of potency. The dihaloethanes, 1,2-dichloroethane and 1,2-dibromoethane, also inactivated the proteinase inhibitory activities of α1-proteinase inhibitor with the former being somewhat more effective than the latter. Concomitant modification of the amino group was also observed with these chemicals.
AB - The inactivating effects of three epoxides and two dihaloethanes on the proteinase inhibitory activities of α1-proteinase inhibitor, as well as those of the plasma itself, were investigated. All of the three epoxides (styrene oxide, ethylene oxide and propylene oxide), individually, inactivated the elastase inhibitory or trypsin inhibitory activity of proteinase inhibitor, and that of whole plasma. Styrene oxide is the most effective inactivator of either purified α1-proteinase inhibitor or plasma, followed by ethylene oxide and propylene oxide in a decreasing order of potency. The dihaloethanes, 1,2-dichloroethane and 1,2-dibromoethane, also inactivated the proteinase inhibitory activities of α1-proteinase inhibitor with the former being somewhat more effective than the latter. Concomitant modification of the amino group was also observed with these chemicals.
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U2 - 10.1007/BF01055521
DO - 10.1007/BF01055521
M3 - Article
C2 - 3261576
AN - SCOPUS:0023889176
SN - 0090-4341
VL - 17
SP - 537
EP - 542
JO - Archives of Environmental Contamination and Toxicology
JF - Archives of Environmental Contamination and Toxicology
IS - 4
ER -