In vitro molecular mechanisms of bisphenol A action

Yelena B. Wetherill, Benson T. Akingbemi, Jun Kanno, John A. McLachlan, Angel Nadal, Carlos Sonnenschein, Cheryl S. Watson, R. Thomas Zoeller, Scott M. Belcher

    Research output: Contribution to journalArticle

    551 Citations (Scopus)

    Abstract

    Bisphenol A (BPA, 2,2-bis (4-hydroxyphenyl) propane; CAS# 80-05-7) is a chemical used primarily in the manufacture of polycarbonate plastic, epoxy resins and as a non-polymer additive to other plastics. Recent evidence has demonstrated that human and wildlife populations are exposed to levels of BPA which cause adverse reproductive and developmental effects in a number of different wildlife species and laboratory animal models. However, there are major uncertainties surrounding the spectrum of BPA's mechanisms of action, the tissue-specific impacts of exposures, and the critical windows of susceptibility during which target tissues are sensitive to BPA exposures. As a foundation to address some of those uncertainties, this review was prepared by the "In vitro" expert sub-panel assembled during the "Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assessing Risks to Human Health" workshop held in Chapel Hill, NC, Nov 28-29, 2006. The specific charge of this expert panel was to review and assess the strength of the published literature pertaining to the mechanisms of BPA action. The resulting document is a detailed review of published studies that have focused on the mechanistic basis of BPA action in diverse experimental models and an assessment of the strength of the evidence regarding the published BPA research.

    Original languageEnglish (US)
    Pages (from-to)178-198
    Number of pages21
    JournalReproductive Toxicology
    Volume24
    Issue number2
    DOIs
    StatePublished - Aug 2007

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    Uncertainty
    Animals
    Tissue
    Epoxy Resins
    Laboratory Animals
    Plastics
    Theoretical Models
    Animal Models
    Health
    Education
    Research
    Population
    bisphenol A
    In Vitro Techniques
    lexan

    Keywords

    • Allergic resonse
    • Androgen receptor
    • Bisphenol A (BPA, 2,2-bis(4-hydroxyphenyl) propane
    • Cell specificity
    • Endocrine disrupting chemical (EDC)
    • Endocrine disruption
    • Estrogen receptor
    • Expert panel review
    • GPR30
    • Immune system
    • In vitro mechanisms
    • Non-classical membrane estrogen receptor
    • Rapid signaling
    • Thyroid hormone
    • Thyroid receptor

    ASJC Scopus subject areas

    • Toxicology

    Cite this

    Wetherill, Y. B., Akingbemi, B. T., Kanno, J., McLachlan, J. A., Nadal, A., Sonnenschein, C., ... Belcher, S. M. (2007). In vitro molecular mechanisms of bisphenol A action. Reproductive Toxicology, 24(2), 178-198. https://doi.org/10.1016/j.reprotox.2007.05.010

    In vitro molecular mechanisms of bisphenol A action. / Wetherill, Yelena B.; Akingbemi, Benson T.; Kanno, Jun; McLachlan, John A.; Nadal, Angel; Sonnenschein, Carlos; Watson, Cheryl S.; Zoeller, R. Thomas; Belcher, Scott M.

    In: Reproductive Toxicology, Vol. 24, No. 2, 08.2007, p. 178-198.

    Research output: Contribution to journalArticle

    Wetherill, YB, Akingbemi, BT, Kanno, J, McLachlan, JA, Nadal, A, Sonnenschein, C, Watson, CS, Zoeller, RT & Belcher, SM 2007, 'In vitro molecular mechanisms of bisphenol A action', Reproductive Toxicology, vol. 24, no. 2, pp. 178-198. https://doi.org/10.1016/j.reprotox.2007.05.010
    Wetherill YB, Akingbemi BT, Kanno J, McLachlan JA, Nadal A, Sonnenschein C et al. In vitro molecular mechanisms of bisphenol A action. Reproductive Toxicology. 2007 Aug;24(2):178-198. https://doi.org/10.1016/j.reprotox.2007.05.010
    Wetherill, Yelena B. ; Akingbemi, Benson T. ; Kanno, Jun ; McLachlan, John A. ; Nadal, Angel ; Sonnenschein, Carlos ; Watson, Cheryl S. ; Zoeller, R. Thomas ; Belcher, Scott M. / In vitro molecular mechanisms of bisphenol A action. In: Reproductive Toxicology. 2007 ; Vol. 24, No. 2. pp. 178-198.
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