In vitro myometrial contractility profiles of different pharmacological agents used for induction of labor

Giuseppe Chiossi, Maged Costantine, Egle Bytautiene, Ancizar Betancourt, Gary Hankins, George Saade, Monica Longo

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

ObjectiveTo investigate the effects of different pharmacological induction agents on myometrial contractility. Study DesignMyometrial biopsies were obtained from 13 term nonlaboring women undergoing scheduled cesarean delivery. Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (1010 mol/L to 105 mol/L) of prostaglandin E1 (PGE1), E2 (PGE2), and oxytocin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using one-way analysis of variance on ranks with Dunn post hoc test. ResultsOxytocin-induced myometrial contractility was superior to PGE1, PGE2, and time controls (CTR) at all the concentrations tested. When only prostaglandins were compared with CTR, PGE1 105 mol/L increased myometrial contractility, and PGE2 had no effects. ConclusionOxytocin and prostaglandins have different effects on myometrial contractility accounting for different mechanisms of action and side effects. The increased uterine contractility observed with PGE1 as compared with PGE2 can contribute to explain the higher success of vaginal delivery.

Original languageEnglish (US)
Pages (from-to)699-703
Number of pages5
JournalAmerican Journal of Perinatology
Volume29
Issue number9
DOIs
StatePublished - 2012

Fingerprint

Induced Labor
Alprostadil
Pharmacology
Prostaglandins
Oxytocin
In Vitro Techniques
Dinoprostone
Area Under Curve
Analysis of Variance
Biopsy

Keywords

  • organ chamber
  • oxytocin
  • prostaglandin E1
  • prostaglandin E2
  • uterine contractility

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

In vitro myometrial contractility profiles of different pharmacological agents used for induction of labor. / Chiossi, Giuseppe; Costantine, Maged; Bytautiene, Egle; Betancourt, Ancizar; Hankins, Gary; Saade, George; Longo, Monica.

In: American Journal of Perinatology, Vol. 29, No. 9, 2012, p. 699-703.

Research output: Contribution to journalArticle

Chiossi, Giuseppe ; Costantine, Maged ; Bytautiene, Egle ; Betancourt, Ancizar ; Hankins, Gary ; Saade, George ; Longo, Monica. / In vitro myometrial contractility profiles of different pharmacological agents used for induction of labor. In: American Journal of Perinatology. 2012 ; Vol. 29, No. 9. pp. 699-703.
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