Although phencyclidine is known to inhibit synaptosomal 3H-dopamine uptake in vitro, it is not known if this effect is produced after in vivo administration of the drug. 3H-dopamine uptake was studied in slices of striatal tissue which were prepared from saline- and phencyclidine-treated rats. Phencyclidine administration significantly reduced 3H-dopamine accumulation by striatal slices. The temporal features of this effect indicate that the inhibition of dopamine reuptake by phencyclidine may account for its reported indirect dopaminergic agonist activity in the intact animal.
|Original language||English (US)|
|Number of pages||4|
|Journal||Substance and Alcohol Actions/Misuse|
|State||Published - Dec 1 1980|
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