In vivo administration of phencyclidine inhibits 3H-dopamine accumulation by rat brain striatal slices

T. W. Vickroy, K. M. Johnson

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Although phencyclidine is known to inhibit synaptosomal 3H-dopamine uptake in vitro, it is not known if this effect is produced after in vivo administration of the drug. 3H-dopamine uptake was studied in slices of striatal tissue which were prepared from saline- and phencyclidine-treated rats. Phencyclidine administration significantly reduced 3H-dopamine accumulation by striatal slices. The temporal features of this effect indicate that the inhibition of dopamine reuptake by phencyclidine may account for its reported indirect dopaminergic agonist activity in the intact animal.

Original languageEnglish (US)
Pages (from-to)351-354
Number of pages4
JournalSubstance and Alcohol Actions/Misuse
Volume1
Issue number4
StatePublished - Dec 1 1980

ASJC Scopus subject areas

  • Medicine(all)

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