In vivo application of 2-D lateral scanning mode Optical Coherence Tomography for glucose sensing

Roman Kuranov; Donald Prough; Veronika Sapozhnikova; Inga Cicenaite; Rinat Esenaliev

doi:10.1117/12.630840

In vivo application of 2-D lateral scanning mode Optical Coherence Tomography for glucose sensing

Roman Kuranov, Donald Prough, Veronika Sapozhnikova, Inga Cicenaite, Rinat Esenaliev

Research output: Contribution to journal › Conference article › peer-review

8 Scopus citations

Abstract

Optical Coherence Tomography (OCT) was recently proposed by our group for noninvasive, continuous monitoring of blood glucose concentration in diabetics as well as in critically ill patients (both diabetic and non-diabetic). In our previous studies we tested OCT-based glucose sensing using one-dimensional (1-D) lateral scanning of the OCT probing beam over the tissue surface. The measured OCT signal was prone to motion artifacts and had high level of speckle noise. In this study we used two-dimensional (2-D) lateral scanning of the OCT probing beam and achieved 3.6-fold reduction of the speckle noise level. We also applied a post-processing Fourier filtration technique that resulted in an additional 2-2.5-fold suppression of noise. Our data indicate that the combination of acquisition time of 30-40s and the Fourier filtration technique may provide OCT monitoring of blood glucose concentration with a sensitivity of 1mM (18 mg/dL).

Original language	English (US)
Article number	60070K
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	6007
DOIs	https://doi.org/10.1117/12.630840
State	Published - 2005
Event	Smart Medical and Biomedical Sensor Technology III - Boston, MA, United States Duration: Oct 24 2005 → Oct 26 2005

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.630840

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title = "In vivo application of 2-D lateral scanning mode Optical Coherence Tomography for glucose sensing",

abstract = "Optical Coherence Tomography (OCT) was recently proposed by our group for noninvasive, continuous monitoring of blood glucose concentration in diabetics as well as in critically ill patients (both diabetic and non-diabetic). In our previous studies we tested OCT-based glucose sensing using one-dimensional (1-D) lateral scanning of the OCT probing beam over the tissue surface. The measured OCT signal was prone to motion artifacts and had high level of speckle noise. In this study we used two-dimensional (2-D) lateral scanning of the OCT probing beam and achieved 3.6-fold reduction of the speckle noise level. We also applied a post-processing Fourier filtration technique that resulted in an additional 2-2.5-fold suppression of noise. Our data indicate that the combination of acquisition time of 30-40s and the Fourier filtration technique may provide OCT monitoring of blood glucose concentration with a sensitivity of 1mM (18 mg/dL).",

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T1 - In vivo application of 2-D lateral scanning mode Optical Coherence Tomography for glucose sensing

AU - Kuranov, Roman

AU - Prough, Donald

AU - Sapozhnikova, Veronika

AU - Cicenaite, Inga

AU - Esenaliev, Rinat

PY - 2005

Y1 - 2005

N2 - Optical Coherence Tomography (OCT) was recently proposed by our group for noninvasive, continuous monitoring of blood glucose concentration in diabetics as well as in critically ill patients (both diabetic and non-diabetic). In our previous studies we tested OCT-based glucose sensing using one-dimensional (1-D) lateral scanning of the OCT probing beam over the tissue surface. The measured OCT signal was prone to motion artifacts and had high level of speckle noise. In this study we used two-dimensional (2-D) lateral scanning of the OCT probing beam and achieved 3.6-fold reduction of the speckle noise level. We also applied a post-processing Fourier filtration technique that resulted in an additional 2-2.5-fold suppression of noise. Our data indicate that the combination of acquisition time of 30-40s and the Fourier filtration technique may provide OCT monitoring of blood glucose concentration with a sensitivity of 1mM (18 mg/dL).

AB - Optical Coherence Tomography (OCT) was recently proposed by our group for noninvasive, continuous monitoring of blood glucose concentration in diabetics as well as in critically ill patients (both diabetic and non-diabetic). In our previous studies we tested OCT-based glucose sensing using one-dimensional (1-D) lateral scanning of the OCT probing beam over the tissue surface. The measured OCT signal was prone to motion artifacts and had high level of speckle noise. In this study we used two-dimensional (2-D) lateral scanning of the OCT probing beam and achieved 3.6-fold reduction of the speckle noise level. We also applied a post-processing Fourier filtration technique that resulted in an additional 2-2.5-fold suppression of noise. Our data indicate that the combination of acquisition time of 30-40s and the Fourier filtration technique may provide OCT monitoring of blood glucose concentration with a sensitivity of 1mM (18 mg/dL).

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T2 - Smart Medical and Biomedical Sensor Technology III

Y2 - 24 October 2005 through 26 October 2005

ER -

In vivo application of 2-D lateral scanning mode Optical Coherence Tomography for glucose sensing

Abstract

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