In vivo application of 2-D lateral scanning mode Optical Coherence Tomography for glucose sensing

Roman Kuranov, Donald Prough, Veronika Sapozhnikova, Inga Cicenaite, Rinat Esenaliev

Research output: Contribution to journalConference article

6 Scopus citations

Abstract

Optical Coherence Tomography (OCT) was recently proposed by our group for noninvasive, continuous monitoring of blood glucose concentration in diabetics as well as in critically ill patients (both diabetic and non-diabetic). In our previous studies we tested OCT-based glucose sensing using one-dimensional (1-D) lateral scanning of the OCT probing beam over the tissue surface. The measured OCT signal was prone to motion artifacts and had high level of speckle noise. In this study we used two-dimensional (2-D) lateral scanning of the OCT probing beam and achieved 3.6-fold reduction of the speckle noise level. We also applied a post-processing Fourier filtration technique that resulted in an additional 2-2.5-fold suppression of noise. Our data indicate that the combination of acquisition time of 30-40s and the Fourier filtration technique may provide OCT monitoring of blood glucose concentration with a sensitivity of 1mM (18 mg/dL).

Original languageEnglish (US)
Article number60070K
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume6007
DOIs
StatePublished - Dec 1 2005
EventSmart Medical and Biomedical Sensor Technology III - Boston, MA, United States
Duration: Oct 24 2005Oct 26 2005

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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