In vivo application of 2-D lateral scanning mode Optical Coherence Tomography for glucose sensing

Roman Kuranov, Donald Prough, Veronika Sapozhnikova, Inga Cicenaite, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Optical Coherence Tomography (OCT) was recently proposed by our group for noninvasive, continuous monitoring of blood glucose concentration in diabetics as well as in critically ill patients (both diabetic and non-diabetic). In our previous studies we tested OCT-based glucose sensing using one-dimensional (1-D) lateral scanning of the OCT probing beam over the tissue surface. The measured OCT signal was prone to motion artifacts and had high level of speckle noise. In this study we used two-dimensional (2-D) lateral scanning of the OCT probing beam and achieved 3.6-fold reduction of the speckle noise level. We also applied a post-processing Fourier filtration technique that resulted in an additional 2-2.5-fold suppression of noise. Our data indicate that the combination of acquisition time of 30-40s and the Fourier filtration technique may provide OCT monitoring of blood glucose concentration with a sensitivity of 1mM (18 mg/dL).

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsB.M. Cullum, J.C. Carter
Volume6007
DOIs
StatePublished - 2005
EventSmart Medical and Biomedical Sensor Technology III - Boston, MA, United States
Duration: Oct 24 2005Oct 26 2005

Other

OtherSmart Medical and Biomedical Sensor Technology III
CountryUnited States
CityBoston, MA
Period10/24/0510/26/05

Fingerprint

Optical tomography
glucose
Glucose
tomography
Scanning
scanning
Speckle
blood
Blood
Monitoring
artifacts
acquisition
retarding
Tissue
sensitivity
Processing

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Kuranov, R., Prough, D., Sapozhnikova, V., Cicenaite, I., & Esenaliev, R. (2005). In vivo application of 2-D lateral scanning mode Optical Coherence Tomography for glucose sensing. In B. M. Cullum, & J. C. Carter (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 6007). [60070K] https://doi.org/10.1117/12.630840

In vivo application of 2-D lateral scanning mode Optical Coherence Tomography for glucose sensing. / Kuranov, Roman; Prough, Donald; Sapozhnikova, Veronika; Cicenaite, Inga; Esenaliev, Rinat.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / B.M. Cullum; J.C. Carter. Vol. 6007 2005. 60070K.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kuranov, R, Prough, D, Sapozhnikova, V, Cicenaite, I & Esenaliev, R 2005, In vivo application of 2-D lateral scanning mode Optical Coherence Tomography for glucose sensing. in BM Cullum & JC Carter (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 6007, 60070K, Smart Medical and Biomedical Sensor Technology III, Boston, MA, United States, 10/24/05. https://doi.org/10.1117/12.630840
Kuranov R, Prough D, Sapozhnikova V, Cicenaite I, Esenaliev R. In vivo application of 2-D lateral scanning mode Optical Coherence Tomography for glucose sensing. In Cullum BM, Carter JC, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 6007. 2005. 60070K https://doi.org/10.1117/12.630840
Kuranov, Roman ; Prough, Donald ; Sapozhnikova, Veronika ; Cicenaite, Inga ; Esenaliev, Rinat. / In vivo application of 2-D lateral scanning mode Optical Coherence Tomography for glucose sensing. Proceedings of SPIE - The International Society for Optical Engineering. editor / B.M. Cullum ; J.C. Carter. Vol. 6007 2005.
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