In vivo cryoablation of prostate tissue with temperature monitoring by optoacoustic imaging

Elena V. Petrova, Massoud Motamedi, Alexander A. Oraevskya, Sergey A. Ermilov

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    7 Citations (Scopus)

    Abstract

    Cryoablation of prostate cancer is an FDA approved clinical procedure, which involves repetitive rapid cooling of a lesion to lethal temperatures of-40°C and below. The major drawback of the technique is the insufficient control over the fast thermal processes that may result in severe complications (impotence, incontinence, perforation of the rectal wall) and morbidity. The developed optoacoustic imaging technique provides non-invasive real-time temperature mapping of tissue adjacent to prostate and enables more efficient control over the procedure, which is necessary to reduce side effects and accelerate the physician's learning curve. In these studies we successfully demonstrated real-time transrectal optoacoustic imaging during prostate cryoablation in live canine model focused on optoacoustic thermography of the rectal wall within the depth of 1cm. Our method utilized previously discovered universal thermal dependence of the normalized optoacoustic response of blood. Nanosecond-pulse radiation of Ti-Sapphire laser tuned to the isosbestic point of hemoglobin (802±3 nm) was delivered via fiberoptic illuminators assembled on both sides of the linear array of the 128-channel transrectal ultrasound probe. Temperature readouts at discrete locations inside and nearby prostate were also performed using standard transperineal needle sensors. The effect of homeostasis on optoacoustic imaging in live tissue was examined during cooling and shown to be significant only within the range of ±1.5°C in respect to the body temperature. Accuracy of in vivo optoacoustic temperature measurements was determined as ±2°C for the range of temperature from +35 to-15°C, which is more than sufficient for tracking the essential isotherms in the course of clinical procedures.

    Original languageEnglish (US)
    Title of host publicationPhotons Plus Ultrasound: Imaging and Sensing 2016
    PublisherSPIE
    Volume9708
    ISBN (Electronic)9781628419429
    DOIs
    StatePublished - 2016
    EventPhotons Plus Ultrasound: Imaging and Sensing 2016 - San Francisco, United States
    Duration: Feb 14 2016Feb 17 2016

    Other

    OtherPhotons Plus Ultrasound: Imaging and Sensing 2016
    CountryUnited States
    CitySan Francisco
    Period2/14/162/17/16

    Fingerprint

    Cryosurgery
    Photoacoustic effect
    Prostate
    Tissue
    Imaging techniques
    Temperature
    Monitoring
    Photoacoustic Techniques
    Hot Temperature
    learning curves
    body temperature
    cooling
    homeostasis
    illuminators
    perforation
    Learning Curve
    physicians
    temperature
    Aluminum Oxide
    hemoglobin

    Keywords

    • blood
    • cryotherapy
    • non-invasive
    • optoacoustics imaging
    • photoacoustic tomography
    • prostate
    • temperature monitoring

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics
    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Radiology Nuclear Medicine and imaging

    Cite this

    Petrova, E. V., Motamedi, M., Oraevskya, A. A., & Ermilov, S. A. (2016). In vivo cryoablation of prostate tissue with temperature monitoring by optoacoustic imaging. In Photons Plus Ultrasound: Imaging and Sensing 2016 (Vol. 9708). [97080G] SPIE. https://doi.org/10.1117/12.2211190

    In vivo cryoablation of prostate tissue with temperature monitoring by optoacoustic imaging. / Petrova, Elena V.; Motamedi, Massoud; Oraevskya, Alexander A.; Ermilov, Sergey A.

    Photons Plus Ultrasound: Imaging and Sensing 2016. Vol. 9708 SPIE, 2016. 97080G.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Petrova, EV, Motamedi, M, Oraevskya, AA & Ermilov, SA 2016, In vivo cryoablation of prostate tissue with temperature monitoring by optoacoustic imaging. in Photons Plus Ultrasound: Imaging and Sensing 2016. vol. 9708, 97080G, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2016, San Francisco, United States, 2/14/16. https://doi.org/10.1117/12.2211190
    Petrova EV, Motamedi M, Oraevskya AA, Ermilov SA. In vivo cryoablation of prostate tissue with temperature monitoring by optoacoustic imaging. In Photons Plus Ultrasound: Imaging and Sensing 2016. Vol. 9708. SPIE. 2016. 97080G https://doi.org/10.1117/12.2211190
    Petrova, Elena V. ; Motamedi, Massoud ; Oraevskya, Alexander A. ; Ermilov, Sergey A. / In vivo cryoablation of prostate tissue with temperature monitoring by optoacoustic imaging. Photons Plus Ultrasound: Imaging and Sensing 2016. Vol. 9708 SPIE, 2016.
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