In vivo detection of superoxide anion production by the brain using a cytochrome c electrode

R. H. Fabian, Douglas Dewitt, T. A. Kent

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

A cytochrome c-coated platinized carbon electrode was utilized to detect superoxide generated by the brain during hypoxia/hypercarbia, focal ischemia, and reperfusion and following fluid percussion brain injury with and without hemorrhagic hypotension and reperfusion in the rat. All three of these forms of brain injury were associated with an increase in the superoxide signal. The cytochrome c electrode proved to be sensitive and responsive enough for minute-by-minute measurement of superoxide generation by brain tissue.

Original languageEnglish (US)
Pages (from-to)242-247
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume15
Issue number2
StatePublished - 1995

Fingerprint

Cytochromes c
Superoxides
Electrodes
Brain Injuries
Reperfusion
Brain
Percussion
Brain Hypoxia
Hypercapnia
Hypotension
Carbon
Ischemia

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Neuroscience(all)

Cite this

In vivo detection of superoxide anion production by the brain using a cytochrome c electrode. / Fabian, R. H.; Dewitt, Douglas; Kent, T. A.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 15, No. 2, 1995, p. 242-247.

Research output: Contribution to journalArticle

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