In vivo effects of cardiotrophin-1

Hongkui Jin, Renhui Yang, Gilbert A. Keller, Anne Ryan, Annie Ko, David Finkle, Todd Swanson, Wei Li, Diane Pennica, William I. Wood, Nicholas F. Paoni

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Cardiotrophin-1 (CT-1) is a recently discovered cytokine that was isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. In this study, the effects of chronic administration of CT-1 to mice (0.5 or 2 μg by intraperitoneal injection, twice a day for 14 days) were determined. A dose-dependent increase in both the heart weight and ventricular weight to body ratios was observed in the treated groups. The body weights of the animals were unaffected. These results indicate that CT-1 can induce cardiac hypertrophy in vivo. CT-1 was not specific for the heart, however. It stimulated the growth of the liver, kidney, and spleen, and caused atrophy of the thymus. CT-1 administration also increased the platelet counts by 70%, with no change in mean platelet volume. Red blood cell counts were increased in the treated animals, and there was a concomitant increase in haemoglobin concentration. Thus, CT-1 has a broad spectrum of biological activities in vivo. This observation is consistent with previous in-vitro findings showing that the mRNA for CT-1 is expressed in several tissues, and that CT-1 can function through binding to the leukaemia inhibitory factor (LIF) receptor and signalling through the gp130 pathway.

Original languageEnglish (US)
Pages (from-to)920-926
Number of pages7
JournalCytokine
Volume8
Issue number12
DOIs
StatePublished - Dec 1996
Externally publishedYes

Fingerprint

Cardiomegaly
Platelets
Animals
OSM-LIF Receptors
Body Weight
Mean Platelet Volume
Thymus
Erythrocyte Count
cardiotrophin 1
Bioactivity
Intraperitoneal Injections
Platelet Count
Cardiac Myocytes
Liver
Thymus Gland
Atrophy
Hemoglobins
Blood
Spleen
Cells

Keywords

  • Cardiac hypertrophy
  • Cardiotrophin-1
  • Cytokine
  • Haematopoiesis
  • Mitochondria

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

Cite this

Jin, H., Yang, R., Keller, G. A., Ryan, A., Ko, A., Finkle, D., ... Paoni, N. F. (1996). In vivo effects of cardiotrophin-1. Cytokine, 8(12), 920-926. https://doi.org/10.1006/cyto.1996.0123

In vivo effects of cardiotrophin-1. / Jin, Hongkui; Yang, Renhui; Keller, Gilbert A.; Ryan, Anne; Ko, Annie; Finkle, David; Swanson, Todd; Li, Wei; Pennica, Diane; Wood, William I.; Paoni, Nicholas F.

In: Cytokine, Vol. 8, No. 12, 12.1996, p. 920-926.

Research output: Contribution to journalArticle

Jin, H, Yang, R, Keller, GA, Ryan, A, Ko, A, Finkle, D, Swanson, T, Li, W, Pennica, D, Wood, WI & Paoni, NF 1996, 'In vivo effects of cardiotrophin-1', Cytokine, vol. 8, no. 12, pp. 920-926. https://doi.org/10.1006/cyto.1996.0123
Jin H, Yang R, Keller GA, Ryan A, Ko A, Finkle D et al. In vivo effects of cardiotrophin-1. Cytokine. 1996 Dec;8(12):920-926. https://doi.org/10.1006/cyto.1996.0123
Jin, Hongkui ; Yang, Renhui ; Keller, Gilbert A. ; Ryan, Anne ; Ko, Annie ; Finkle, David ; Swanson, Todd ; Li, Wei ; Pennica, Diane ; Wood, William I. ; Paoni, Nicholas F. / In vivo effects of cardiotrophin-1. In: Cytokine. 1996 ; Vol. 8, No. 12. pp. 920-926.
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