In vivo metabolism of the cardiovascular toxin, allylamine

Paul J. Boor, Radhika Sanduja, Thomas J. Nelson, G. A.S. Ansari

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Previous evidence from this laboratory demonstrated that allylamine, a known cardiovascular toxin, is metabolized in vitro to acrolein, which has been hypothesized to act as a distal toxin. In this study, 3-hydroxypropylmercapturic acid was isolated and identified by MS, NMR, and 2D-NMR spectroscopy as the sole urinary metabolite of allylamine metabolism in vivo. Parallel experiments showed reduced glutathione (GSH) depletion in several organs (most marked in aorta, blood, and lung), which is consistent with GSH conjugation of the proposed acrolein intermediate. These findings indicate that allylamine was metabolized in vivo to a highly reactive aldehyde which was converted to a mercapturic acid through a GSH conjugation pathway; the exact mechanisms of cellular damage remain unclear.

Original languageEnglish (US)
Pages (from-to)4347-4353
Number of pages7
JournalBiochemical Pharmacology
Volume36
Issue number24
DOIs
StatePublished - Dec 15 1987

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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