In vivo monitoring of blood oxygenation in large veins with a triple-wavelength optoacoustic system

H. P. Brecht, Donald Prough, Y. Y. Petrov, I. Patrikeev, I. Y. Petrova, D. J. Deyo, I. Cicenaite, Rinat Esenaliev

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A noninvasive optoacoustic technique could be a clinically useful alternative to existing, invasive methods for cerebral oxygenation monitoring. Recently we proposed to use an optoacoustic technique for monitoring cerebral blood oxygenation by probing large cerebral and neck veins including the superior sagittal sinus and the internal jugular vein. In these studies we used a multi-wavelength optoacoustic system with a nanosecond optical parametric oscillator as a light source and a custommade optoacoustic probe for the measurement of the optoacoustic signals in vivo from the area of the sheep neck overlying the external jugular vein, which is similar in diameter and depth to the human internal jugular vein. Optoacoustic signals induced in venous blood were measured with high resolution despite the presence of a thick layer of tissues (up to 10 mm) between the external jugular vein and the optoacoustic probe. Three wavelengths were chosen to provide accurate and stable measurements of blood oxygenation: signals at 700 nm and 1064 nm demonstrated high correlation with actual oxygenation measured invasively with CO-Oximeter ("gold standard"), while the signal at 800 nm (isosbestic point) was independent of blood oxygenation and was used for calibration.

Original languageEnglish (US)
Pages (from-to)16261-16269
Number of pages9
JournalOptics Express
Volume15
Issue number24
DOIs
StatePublished - Nov 26 2007

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oxygenation
veins
blood
wavelengths
sheep
sinuses
probes
parametric amplifiers
light sources
high resolution

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

In vivo monitoring of blood oxygenation in large veins with a triple-wavelength optoacoustic system. / Brecht, H. P.; Prough, Donald; Petrov, Y. Y.; Patrikeev, I.; Petrova, I. Y.; Deyo, D. J.; Cicenaite, I.; Esenaliev, Rinat.

In: Optics Express, Vol. 15, No. 24, 26.11.2007, p. 16261-16269.

Research output: Contribution to journalArticle

Brecht, HP, Prough, D, Petrov, YY, Patrikeev, I, Petrova, IY, Deyo, DJ, Cicenaite, I & Esenaliev, R 2007, 'In vivo monitoring of blood oxygenation in large veins with a triple-wavelength optoacoustic system', Optics Express, vol. 15, no. 24, pp. 16261-16269. https://doi.org/10.1364/OE.15.016261
Brecht, H. P. ; Prough, Donald ; Petrov, Y. Y. ; Patrikeev, I. ; Petrova, I. Y. ; Deyo, D. J. ; Cicenaite, I. ; Esenaliev, Rinat. / In vivo monitoring of blood oxygenation in large veins with a triple-wavelength optoacoustic system. In: Optics Express. 2007 ; Vol. 15, No. 24. pp. 16261-16269.
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