In Vivo Reduction of Bacterial Populations in the Urinary Tract of Catheterized Sheep by Iontophoresis

C. P. Davis, M. E. Shirtliff, J. M. Scimeca, S. L. Hoskins, M. M. Warren

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Purpose: Iontophoresis kills microbes in vitro and, therefore, may be a useful method for eliminating microbial populations associated with catheter-induced urinary tract infections in vivo. Materials and Methods: Catheters were modified to deliver current to platinum electrodes in the catheter tip. Female sheep were catheterized with this iontophoretic catheter and left ambulatory. In 5 sheep (experimental group) 400 microampere was applied to the catheter and withheld in 4 sheep (control group) for 20 to 21 days. The animals were then sacrificed. During the study, types and concentrations of bacteria, and physical and chemical characteristics of the urine samples were determined. Results: Throughout the study, bacteria levels were reduced in urinary tracts of the experimental group (103 to 104 microbes per ml.) compared with the control group (107 microbes per ml.), without extensive alterations to urine chemistry or the sheep urinary tract. Conclusions: Since iontophoresis safely reduced bacterial populations in catheterized sheep, this technology may reduce or eliminate nosocomial, catheter-induced urinary tract infections in humans.

Original languageEnglish (US)
Pages (from-to)1948-1953
Number of pages6
JournalThe Journal of urology
Volume154
Issue number5
DOIs
StatePublished - Nov 1995
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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