In vivo study of glucose-induced changes in skin properties assessed with optical coherence tomography

Roman V. Kuranov, Veronika V. Sapozhnikova, Donald Prough, Inga Cicenaite, Rinat Esenaliev

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Recently, our in vivo studies demonstrated a strong correlation between blood glucose concentration and the slope of the optical coherence tomography (OCT) signal when the probing beam was scanned over a straight line. To improve the sensitivity of OCT for blood glucose monitoring, two-dimensional (2D) lateral scanning of the OCT probing beam was proposed. Depth-dependent changes in pig skin properties with variation of blood glucose concentration were revealed due to significant suppression of speckle noise and motion artefacts in 2D scanning mode. The correlation coefficient of the OCT signal slope with blood glucose concentration varied periodically in the range from -0.9 to +0.9 depending on depth. The period of variation of the correlation coefficient was 100-150 νm that corresponded to the distance between neighbour collagen bundles. We also observed a decrease of skin thickness by 10 ± 7.5 νm with an increase of blood glucose concentration by 277 ± 56 mg dl -1. Mechanisms of glucose-induced changes in skin properties owing to tissue layer shift caused by dehydration associated with the glucose osmotic effect were considered.

Original languageEnglish (US)
Article number001
Pages (from-to)3885-3900
Number of pages16
JournalPhysics in Medicine and Biology
Volume51
Issue number16
DOIs
StatePublished - Aug 21 2006

Fingerprint

Optical tomography
Optical Coherence Tomography
glucose
Glucose
Blood Glucose
Skin
tomography
blood
Blood
correlation coefficients
Dehydration
slopes
Scanning
Artifacts
scanning
swine
Swine
Collagen
collagens
Speckle

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

In vivo study of glucose-induced changes in skin properties assessed with optical coherence tomography. / Kuranov, Roman V.; Sapozhnikova, Veronika V.; Prough, Donald; Cicenaite, Inga; Esenaliev, Rinat.

In: Physics in Medicine and Biology, Vol. 51, No. 16, 001, 21.08.2006, p. 3885-3900.

Research output: Contribution to journalArticle

Kuranov, Roman V. ; Sapozhnikova, Veronika V. ; Prough, Donald ; Cicenaite, Inga ; Esenaliev, Rinat. / In vivo study of glucose-induced changes in skin properties assessed with optical coherence tomography. In: Physics in Medicine and Biology. 2006 ; Vol. 51, No. 16. pp. 3885-3900.
@article{4fe56ce420d34fddb10b74357f03428d,
title = "In vivo study of glucose-induced changes in skin properties assessed with optical coherence tomography",
abstract = "Recently, our in vivo studies demonstrated a strong correlation between blood glucose concentration and the slope of the optical coherence tomography (OCT) signal when the probing beam was scanned over a straight line. To improve the sensitivity of OCT for blood glucose monitoring, two-dimensional (2D) lateral scanning of the OCT probing beam was proposed. Depth-dependent changes in pig skin properties with variation of blood glucose concentration were revealed due to significant suppression of speckle noise and motion artefacts in 2D scanning mode. The correlation coefficient of the OCT signal slope with blood glucose concentration varied periodically in the range from -0.9 to +0.9 depending on depth. The period of variation of the correlation coefficient was 100-150 νm that corresponded to the distance between neighbour collagen bundles. We also observed a decrease of skin thickness by 10 ± 7.5 νm with an increase of blood glucose concentration by 277 ± 56 mg dl -1. Mechanisms of glucose-induced changes in skin properties owing to tissue layer shift caused by dehydration associated with the glucose osmotic effect were considered.",
author = "Kuranov, {Roman V.} and Sapozhnikova, {Veronika V.} and Donald Prough and Inga Cicenaite and Rinat Esenaliev",
year = "2006",
month = "8",
day = "21",
doi = "10.1088/0031-9155/51/16/001",
language = "English (US)",
volume = "51",
pages = "3885--3900",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP Publishing Ltd.",
number = "16",

}

TY - JOUR

T1 - In vivo study of glucose-induced changes in skin properties assessed with optical coherence tomography

AU - Kuranov, Roman V.

AU - Sapozhnikova, Veronika V.

AU - Prough, Donald

AU - Cicenaite, Inga

AU - Esenaliev, Rinat

PY - 2006/8/21

Y1 - 2006/8/21

N2 - Recently, our in vivo studies demonstrated a strong correlation between blood glucose concentration and the slope of the optical coherence tomography (OCT) signal when the probing beam was scanned over a straight line. To improve the sensitivity of OCT for blood glucose monitoring, two-dimensional (2D) lateral scanning of the OCT probing beam was proposed. Depth-dependent changes in pig skin properties with variation of blood glucose concentration were revealed due to significant suppression of speckle noise and motion artefacts in 2D scanning mode. The correlation coefficient of the OCT signal slope with blood glucose concentration varied periodically in the range from -0.9 to +0.9 depending on depth. The period of variation of the correlation coefficient was 100-150 νm that corresponded to the distance between neighbour collagen bundles. We also observed a decrease of skin thickness by 10 ± 7.5 νm with an increase of blood glucose concentration by 277 ± 56 mg dl -1. Mechanisms of glucose-induced changes in skin properties owing to tissue layer shift caused by dehydration associated with the glucose osmotic effect were considered.

AB - Recently, our in vivo studies demonstrated a strong correlation between blood glucose concentration and the slope of the optical coherence tomography (OCT) signal when the probing beam was scanned over a straight line. To improve the sensitivity of OCT for blood glucose monitoring, two-dimensional (2D) lateral scanning of the OCT probing beam was proposed. Depth-dependent changes in pig skin properties with variation of blood glucose concentration were revealed due to significant suppression of speckle noise and motion artefacts in 2D scanning mode. The correlation coefficient of the OCT signal slope with blood glucose concentration varied periodically in the range from -0.9 to +0.9 depending on depth. The period of variation of the correlation coefficient was 100-150 νm that corresponded to the distance between neighbour collagen bundles. We also observed a decrease of skin thickness by 10 ± 7.5 νm with an increase of blood glucose concentration by 277 ± 56 mg dl -1. Mechanisms of glucose-induced changes in skin properties owing to tissue layer shift caused by dehydration associated with the glucose osmotic effect were considered.

UR - http://www.scopus.com/inward/record.url?scp=33746781794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746781794&partnerID=8YFLogxK

U2 - 10.1088/0031-9155/51/16/001

DO - 10.1088/0031-9155/51/16/001

M3 - Article

VL - 51

SP - 3885

EP - 3900

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 16

M1 - 001

ER -