Inability of thoracic duct drain to prevent hyperacute rejection

J. C. Fish, M. W. Flye, A. Williams, Courtney Townsend, S. Rajaraman, J. A. Hokanson, H. E. Sarles, J. D. Bell, A. R. Remmers

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Serum and lymph albumin and Ig levels were measured during 6 weeks of lymphocyte depletion by thoracic duct drainage (TDD) in 21 patients prior to renal allotransplantation. In ten of these patients, the amount of protein lost from all sources (blood sampling, dialysis, and lymph centrifugation) was measured. The total amount of albumin lost was significantly greater than the amount of IgG lost. However, serum IgG declined at a faster rate and to a greater extent than albumin. Hyperacute or acute humoral rejection occurred in 14 grafts in 10 patients prepared by TDD despite negative crossmatch tests. These data suggest that removal of lymphocytes by TDD, rather than protein loss alone, affects IgG levels. On the other hand, TDD and IgG depletion do not prevent hyperacute or acute humoral rejection. This is most likely due to the inability of currently employed crossmatch tests to predict accurately which patients will manifest antibody-mediated graft rejection.

Original languageEnglish (US)
Pages (from-to)134-139
Number of pages6
JournalTransplantation
Volume36
Issue number2
StatePublished - 1983

Fingerprint

Thoracic Duct
Drainage
Immunoglobulin G
Lymph
Albumins
Lymphocyte Depletion
Graft Rejection
Centrifugation
Serum Albumin
Dialysis
Proteins
Lymphocytes
Transplants
Kidney
Antibodies
Serum

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Fish, J. C., Flye, M. W., Williams, A., Townsend, C., Rajaraman, S., Hokanson, J. A., ... Remmers, A. R. (1983). Inability of thoracic duct drain to prevent hyperacute rejection. Transplantation, 36(2), 134-139.

Inability of thoracic duct drain to prevent hyperacute rejection. / Fish, J. C.; Flye, M. W.; Williams, A.; Townsend, Courtney; Rajaraman, S.; Hokanson, J. A.; Sarles, H. E.; Bell, J. D.; Remmers, A. R.

In: Transplantation, Vol. 36, No. 2, 1983, p. 134-139.

Research output: Contribution to journalArticle

Fish, JC, Flye, MW, Williams, A, Townsend, C, Rajaraman, S, Hokanson, JA, Sarles, HE, Bell, JD & Remmers, AR 1983, 'Inability of thoracic duct drain to prevent hyperacute rejection', Transplantation, vol. 36, no. 2, pp. 134-139.
Fish JC, Flye MW, Williams A, Townsend C, Rajaraman S, Hokanson JA et al. Inability of thoracic duct drain to prevent hyperacute rejection. Transplantation. 1983;36(2):134-139.
Fish, J. C. ; Flye, M. W. ; Williams, A. ; Townsend, Courtney ; Rajaraman, S. ; Hokanson, J. A. ; Sarles, H. E. ; Bell, J. D. ; Remmers, A. R. / Inability of thoracic duct drain to prevent hyperacute rejection. In: Transplantation. 1983 ; Vol. 36, No. 2. pp. 134-139.
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