Inadequate weight gain in overweight and obese pregnant women

What is the effect on fetal growth?

Patrick M. Catalano, Lisa Mele, Mark B. Landon, Susan M. Ramin, Uma M. Reddy, Brian Casey, Ronald J. Wapner, Michael W. Varner, Dwight J. Rouse, John M. Thorp, George Saade, Yoram Sorokin, Alan M. Peaceman, Jorge E. Tolosa

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Objective We sought to evaluate inadequate gestational weight gain and fetal growth among overweight and obese women. Study Design We conducted an analysis of prospective singleton term pregnancies in which 1053 overweight and obese women gained 5 kg (14.4 6.2 kg) or 188 who either lost or gained 5 kg (1.1 4.4 kg). Birthweight, fat mass, and lean mass were assessed using anthropometry. Small for gestational age (SGA) was defined as 10th percentile of a standard US population. Univariable and multivariable analysis evaluated the association between weight change and neonatal morphometry. Results There was no significant difference in age, race, smoking, parity, or gestational age between groups. Weight loss or gain 5 kg was associated with SGA, 18/188 (9.6%) vs 51/1053 (4.9%); (adjusted odds ratio, 2.6; 95% confidence interval, 1.4-4.7 P =.003). Neonates of women who lost or gained 5 kg had lower birthweight (3258-443 vs 3467 492 g, P.0001), fat mass (403 175 vs 471 193 g, P 0001), and lean mass (2855 321 vs 2995 347 g, P <.0001), and smaller length, percent fat mass, and head circumference. Adjusting for diabetic status, prepregnancy body mass index, smoking, parity, study site, gestational age, and sex, neonates of women who gained ≤5 kg had significantly lower birthweight, lean body mass, fat mass, percent fat mass, head circumference, and length. There were no significant differences in neonatal outcomes between those who lost weight and those who gained ≤5 kg. Conclusion In overweight and obese women weight loss or gain ≤5 kg is associated with increased risk of SGA and decreased neonatal fat mass, lean mass, and head circumference.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume211
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Fetal Development
Weight Gain
Pregnant Women
Gestational Age
Fats
Head
Parity
Weight Loss
Smoking
Newborn Infant
Weights and Measures
Anthropometry
Body Mass Index
Age Groups
Odds Ratio
Confidence Intervals
Pregnancy
Population

Keywords

  • fetal anthropometry
  • gestational diabetes
  • gestational weight loss

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Inadequate weight gain in overweight and obese pregnant women : What is the effect on fetal growth? / Catalano, Patrick M.; Mele, Lisa; Landon, Mark B.; Ramin, Susan M.; Reddy, Uma M.; Casey, Brian; Wapner, Ronald J.; Varner, Michael W.; Rouse, Dwight J.; Thorp, John M.; Saade, George; Sorokin, Yoram; Peaceman, Alan M.; Tolosa, Jorge E.

In: American Journal of Obstetrics and Gynecology, Vol. 211, No. 2, 2014.

Research output: Contribution to journalArticle

Catalano, PM, Mele, L, Landon, MB, Ramin, SM, Reddy, UM, Casey, B, Wapner, RJ, Varner, MW, Rouse, DJ, Thorp, JM, Saade, G, Sorokin, Y, Peaceman, AM & Tolosa, JE 2014, 'Inadequate weight gain in overweight and obese pregnant women: What is the effect on fetal growth?', American Journal of Obstetrics and Gynecology, vol. 211, no. 2. https://doi.org/10.1016/j.ajog.2014.02.004
Catalano, Patrick M. ; Mele, Lisa ; Landon, Mark B. ; Ramin, Susan M. ; Reddy, Uma M. ; Casey, Brian ; Wapner, Ronald J. ; Varner, Michael W. ; Rouse, Dwight J. ; Thorp, John M. ; Saade, George ; Sorokin, Yoram ; Peaceman, Alan M. ; Tolosa, Jorge E. / Inadequate weight gain in overweight and obese pregnant women : What is the effect on fetal growth?. In: American Journal of Obstetrics and Gynecology. 2014 ; Vol. 211, No. 2.
@article{fc49586fbc564763b4c259738d575da5,
title = "Inadequate weight gain in overweight and obese pregnant women: What is the effect on fetal growth?",
abstract = "Objective We sought to evaluate inadequate gestational weight gain and fetal growth among overweight and obese women. Study Design We conducted an analysis of prospective singleton term pregnancies in which 1053 overweight and obese women gained 5 kg (14.4 6.2 kg) or 188 who either lost or gained 5 kg (1.1 4.4 kg). Birthweight, fat mass, and lean mass were assessed using anthropometry. Small for gestational age (SGA) was defined as 10th percentile of a standard US population. Univariable and multivariable analysis evaluated the association between weight change and neonatal morphometry. Results There was no significant difference in age, race, smoking, parity, or gestational age between groups. Weight loss or gain 5 kg was associated with SGA, 18/188 (9.6{\%}) vs 51/1053 (4.9{\%}); (adjusted odds ratio, 2.6; 95{\%} confidence interval, 1.4-4.7 P =.003). Neonates of women who lost or gained 5 kg had lower birthweight (3258-443 vs 3467 492 g, P.0001), fat mass (403 175 vs 471 193 g, P 0001), and lean mass (2855 321 vs 2995 347 g, P <.0001), and smaller length, percent fat mass, and head circumference. Adjusting for diabetic status, prepregnancy body mass index, smoking, parity, study site, gestational age, and sex, neonates of women who gained ≤5 kg had significantly lower birthweight, lean body mass, fat mass, percent fat mass, head circumference, and length. There were no significant differences in neonatal outcomes between those who lost weight and those who gained ≤5 kg. Conclusion In overweight and obese women weight loss or gain ≤5 kg is associated with increased risk of SGA and decreased neonatal fat mass, lean mass, and head circumference.",
keywords = "fetal anthropometry, gestational diabetes, gestational weight loss",
author = "Catalano, {Patrick M.} and Lisa Mele and Landon, {Mark B.} and Ramin, {Susan M.} and Reddy, {Uma M.} and Brian Casey and Wapner, {Ronald J.} and Varner, {Michael W.} and Rouse, {Dwight J.} and Thorp, {John M.} and George Saade and Yoram Sorokin and Peaceman, {Alan M.} and Tolosa, {Jorge E.}",
year = "2014",
doi = "10.1016/j.ajog.2014.02.004",
language = "English (US)",
volume = "211",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Inadequate weight gain in overweight and obese pregnant women

T2 - What is the effect on fetal growth?

AU - Catalano, Patrick M.

AU - Mele, Lisa

AU - Landon, Mark B.

AU - Ramin, Susan M.

AU - Reddy, Uma M.

AU - Casey, Brian

AU - Wapner, Ronald J.

AU - Varner, Michael W.

AU - Rouse, Dwight J.

AU - Thorp, John M.

AU - Saade, George

AU - Sorokin, Yoram

AU - Peaceman, Alan M.

AU - Tolosa, Jorge E.

PY - 2014

Y1 - 2014

N2 - Objective We sought to evaluate inadequate gestational weight gain and fetal growth among overweight and obese women. Study Design We conducted an analysis of prospective singleton term pregnancies in which 1053 overweight and obese women gained 5 kg (14.4 6.2 kg) or 188 who either lost or gained 5 kg (1.1 4.4 kg). Birthweight, fat mass, and lean mass were assessed using anthropometry. Small for gestational age (SGA) was defined as 10th percentile of a standard US population. Univariable and multivariable analysis evaluated the association between weight change and neonatal morphometry. Results There was no significant difference in age, race, smoking, parity, or gestational age between groups. Weight loss or gain 5 kg was associated with SGA, 18/188 (9.6%) vs 51/1053 (4.9%); (adjusted odds ratio, 2.6; 95% confidence interval, 1.4-4.7 P =.003). Neonates of women who lost or gained 5 kg had lower birthweight (3258-443 vs 3467 492 g, P.0001), fat mass (403 175 vs 471 193 g, P 0001), and lean mass (2855 321 vs 2995 347 g, P <.0001), and smaller length, percent fat mass, and head circumference. Adjusting for diabetic status, prepregnancy body mass index, smoking, parity, study site, gestational age, and sex, neonates of women who gained ≤5 kg had significantly lower birthweight, lean body mass, fat mass, percent fat mass, head circumference, and length. There were no significant differences in neonatal outcomes between those who lost weight and those who gained ≤5 kg. Conclusion In overweight and obese women weight loss or gain ≤5 kg is associated with increased risk of SGA and decreased neonatal fat mass, lean mass, and head circumference.

AB - Objective We sought to evaluate inadequate gestational weight gain and fetal growth among overweight and obese women. Study Design We conducted an analysis of prospective singleton term pregnancies in which 1053 overweight and obese women gained 5 kg (14.4 6.2 kg) or 188 who either lost or gained 5 kg (1.1 4.4 kg). Birthweight, fat mass, and lean mass were assessed using anthropometry. Small for gestational age (SGA) was defined as 10th percentile of a standard US population. Univariable and multivariable analysis evaluated the association between weight change and neonatal morphometry. Results There was no significant difference in age, race, smoking, parity, or gestational age between groups. Weight loss or gain 5 kg was associated with SGA, 18/188 (9.6%) vs 51/1053 (4.9%); (adjusted odds ratio, 2.6; 95% confidence interval, 1.4-4.7 P =.003). Neonates of women who lost or gained 5 kg had lower birthweight (3258-443 vs 3467 492 g, P.0001), fat mass (403 175 vs 471 193 g, P 0001), and lean mass (2855 321 vs 2995 347 g, P <.0001), and smaller length, percent fat mass, and head circumference. Adjusting for diabetic status, prepregnancy body mass index, smoking, parity, study site, gestational age, and sex, neonates of women who gained ≤5 kg had significantly lower birthweight, lean body mass, fat mass, percent fat mass, head circumference, and length. There were no significant differences in neonatal outcomes between those who lost weight and those who gained ≤5 kg. Conclusion In overweight and obese women weight loss or gain ≤5 kg is associated with increased risk of SGA and decreased neonatal fat mass, lean mass, and head circumference.

KW - fetal anthropometry

KW - gestational diabetes

KW - gestational weight loss

UR - http://www.scopus.com/inward/record.url?scp=84905121421&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905121421&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2014.02.004

DO - 10.1016/j.ajog.2014.02.004

M3 - Article

VL - 211

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 2

ER -