InBr3-mediated one-pot synthesis of 2-(polyhydroxylatedalkyl)-N- aryl-/-alkylpyrroles from 1,2-cyclopropa-3-pyranone and amines

Pingyuan Wang, Shanshan Song, Zehong Miao, Guangfu Yang, Ao Zhang

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

An efficient one-pot synthesis of polyhydroxyalkyl-substituted pyrroles from 1,2-cyclopropa-3-pyranones with primary amines is reported. With 10% of InBr3 as the catalyst, both aryl- and alkylamines as well as various 1,2-cyclopropa-3-pyranones are well tolerated. This method is highly appealing because of its one-pot process, mild reaction conditions, substrate simplicity, and broad substrate scope.

Original languageEnglish (US)
Pages (from-to)3852-3855
Number of pages4
JournalOrganic Letters
Volume15
Issue number15
DOIs
StatePublished - Aug 2 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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