InBr3-mediated one-pot synthesis of 2-(polyhydroxylatedalkyl)-N- aryl-/-alkylpyrroles from 1,2-cyclopropa-3-pyranone and amines

Pingyuan Wang, Shanshan Song, Zehong Miao, Guangfu Yang, Ao Zhang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

An efficient one-pot synthesis of polyhydroxyalkyl-substituted pyrroles from 1,2-cyclopropa-3-pyranones with primary amines is reported. With 10% of InBr3 as the catalyst, both aryl- and alkylamines as well as various 1,2-cyclopropa-3-pyranones are well tolerated. This method is highly appealing because of its one-pot process, mild reaction conditions, substrate simplicity, and broad substrate scope.

Original languageEnglish (US)
Pages (from-to)3852-3855
Number of pages4
JournalOrganic Letters
Volume15
Issue number15
DOIs
StatePublished - Aug 2 2013
Externally publishedYes

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Pyrroles
Amines
amines
pyrroles
Substrates
synthesis
catalysts
Catalysts
indium bromide

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

InBr3-mediated one-pot synthesis of 2-(polyhydroxylatedalkyl)-N- aryl-/-alkylpyrroles from 1,2-cyclopropa-3-pyranone and amines. / Wang, Pingyuan; Song, Shanshan; Miao, Zehong; Yang, Guangfu; Zhang, Ao.

In: Organic Letters, Vol. 15, No. 15, 02.08.2013, p. 3852-3855.

Research output: Contribution to journalArticle

Wang, Pingyuan ; Song, Shanshan ; Miao, Zehong ; Yang, Guangfu ; Zhang, Ao. / InBr3-mediated one-pot synthesis of 2-(polyhydroxylatedalkyl)-N- aryl-/-alkylpyrroles from 1,2-cyclopropa-3-pyranone and amines. In: Organic Letters. 2013 ; Vol. 15, No. 15. pp. 3852-3855.
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AU - Zhang, Ao

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