Incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA)

Sebastian G. de la Fuente, Eugene P. Ceppa, Srinevas K. Reddy, Bryan M. Clary, Douglas Tyler, Theodore N. Pappas

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Introduction: The lack of accurate markers makes preoperative differentiation between pancreatic cancer and non-malignant head lesions clinically challenging. In this study, we investigated the incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by EUS and EUS-guided FNA. Methods: Medical records of consecutive patients who underwent pancreaticoduodenectomy at Duke University were reviewed. Demographics, clinicopathologic characteristics, preoperative imaging, EUS, EUS-guided FNA, and postoperative outcomes were analyzed. Results: Seven percent of the total 494 patients studied were found to have benign disease on postoperative pathology. Fifty-nine percent of these patients with benign disease underwent preoperative EUS. EUS was positive for a head mass in 70%, demonstrated enlarged lymph nodes in 27%, and showed signs concerning for vascular invasion in 13%. FNA was suspicious or indeterminate for cancer in 63% of patients. Postoperative complications occurred in 47% and one patient died after surgery. The overall pancreatic leak rate was 15%. Conclusions: Even with aggressive use of preoperative evaluation, there is still a small subset of patients where malignancy cannot be excluded without pancreaticoduodenectomy.

Original languageEnglish (US)
Pages (from-to)1139-1142
Number of pages4
JournalJournal of Gastrointestinal Surgery
Volume14
Issue number7
DOIs
StatePublished - 2010
Externally publishedYes

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Endosonography
Fine Needle Biopsy
Pancreatic Neoplasms
Incidence
Pancreaticoduodenectomy
Head
Medical Records
Blood Vessels
Neoplasms
Lymph Nodes
Demography
Pathology

Keywords

  • Cancer
  • Endoscopic ultrasonography
  • Pancreas
  • Pancreaticoduodenectomy

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology
  • Medicine(all)

Cite this

Incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA). / de la Fuente, Sebastian G.; Ceppa, Eugene P.; Reddy, Srinevas K.; Clary, Bryan M.; Tyler, Douglas; Pappas, Theodore N.

In: Journal of Gastrointestinal Surgery, Vol. 14, No. 7, 2010, p. 1139-1142.

Research output: Contribution to journalArticle

de la Fuente, Sebastian G. ; Ceppa, Eugene P. ; Reddy, Srinevas K. ; Clary, Bryan M. ; Tyler, Douglas ; Pappas, Theodore N. / Incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA). In: Journal of Gastrointestinal Surgery. 2010 ; Vol. 14, No. 7. pp. 1139-1142.
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