Inclusion of methoxy groups inverts the thermodynamic stabilities of DNA-RNA hybrid duplexes: A molecular dynamics simulation study

Keyphrases

• Thermodynamic Stability 100%
• DNA-RNA Hybrids 100%
• Methoxy Group 100%
• Hybrid-duplex 100%
• Molecular Dynamics Simulation Study 100%
• A Molecular Dynamics Simulation 100%
• Duplex 50%
• Nucleic Acids 33%
• 2′-O-methyl 33%
• 2′-O-methylation 33%
• Two-hybrid 16%
• Antiretroviral Therapy 16%
• Antisense 16%
• DNA Strands 16%
• Methyl Groups 16%
• Molecular Dynamics Simulation 16%
• Modified nucleosides 16%
• Hydrophobicity 16%
• Duplex Stability 16%
• Hydration Pattern 16%
• Deoxyribose 16%
• Furanose 16%
• Special Properties 16%
• Antisense Therapy 16%
• Chemically Modified nucleic Acids 16%
• Free Energy Component Analysis 16%
• Dynamic Patterns 16%
• Binding Free Energy Calculations 16%
• Absolute Binding Free Energy 16%
• Nucleic Acid Stability 16%

Biochemistry, Genetics and Molecular Biology

• Nucleic Acid 100%
• DNA RNA Hybridization 100%
• Thermodynamics 100%
• Antisense 40%
• Conformation 40%
• RNA 20%
• DNA Strand 20%
• Hydrophobicity 20%
• Deoxyribose 20%
• Furanose 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Nucleic Acid 100%
• Antiviral Therapy 20%
• Methyl Group 20%
• Hydration 20%
• Hydrophobicity 20%
• Deoxyribose 20%