Incontinentia Pigmenti: Evidence for Both Neutrophil and Lymphocyte Dysfunction

R. Thomas Jessen; Dennis E. Van Epps; James S. Goodwin; James Bowerman

doi:10.1001/archderm.1978.01640200036009

Incontinentia Pigmenti: Evidence for Both Neutrophil and Lymphocyte Dysfunction

R. Thomas Jessen, Dennis E. Van Epps, James S. Goodwin, James Bowerman

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A child with incontinentia pigmenti (Bloch-Sultzberger syndrome) had recurrent pneumococcal meningitis and pneumococcal bacteremia with associated subdural hematomas. Immunologic evaluation revealed defective neutrophil chemotaxis with normal neutrophil chemiluminescense. In addition, lymphocytes showed a depressed proliferative response to phytohemagglutinin stimulation. An immunologic defect may prove to be part of this syndrome.

Original language	English (US)
Pages (from-to)	1182-1186
Number of pages	5
Journal	Archives of Dermatology
Volume	114
Issue number	8
DOIs	https://doi.org/10.1001/archderm.1978.01640200036009
State	Published - Aug 1978
Externally published	Yes

ASJC Scopus subject areas

Dermatology

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abstract = "A child with incontinentia pigmenti (Bloch-Sultzberger syndrome) had recurrent pneumococcal meningitis and pneumococcal bacteremia with associated subdural hematomas. Immunologic evaluation revealed defective neutrophil chemotaxis with normal neutrophil chemiluminescense. In addition, lymphocytes showed a depressed proliferative response to phytohemagglutinin stimulation. An immunologic defect may prove to be part of this syndrome.",

author = "Jessen, \{R. Thomas\} and \{Van Epps\}, \{Dennis E.\} and Goodwin, \{James S.\} and James Bowerman",

year = "1978",

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AU - Bowerman, James

PY - 1978/8

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AB - A child with incontinentia pigmenti (Bloch-Sultzberger syndrome) had recurrent pneumococcal meningitis and pneumococcal bacteremia with associated subdural hematomas. Immunologic evaluation revealed defective neutrophil chemotaxis with normal neutrophil chemiluminescense. In addition, lymphocytes showed a depressed proliferative response to phytohemagglutinin stimulation. An immunologic defect may prove to be part of this syndrome.

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Incontinentia Pigmenti: Evidence for Both Neutrophil and Lymphocyte Dysfunction

Abstract

ASJC Scopus subject areas

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