Abstract
Objective: To determine if inhaled albuterol (salbutamol) increases oxygen consumption (V′o<inf>2</inf>) in children and, if so, the duration of this effect.
Design: Oxygen consumption was measured by indirect calorimetry using the Argon dilution technique with a respiratory mass spectrometer. After measurement of baseline values, albuterol was administered and subsequent measurements were performed at 10 minutes, 1 hour, 2 hours, 3 hours, and 4 hours.
Setting: Multidisciplinary PICU in a university teaching hospital.
Patients: Eleven intubated infants and children (five girls, six boys) with a mean age of 20 months (range, 1 mo to 8 yr) and a mean weight of 10.7 kg (range, 3.1-23 kg) who required therapeutic albuterol inhalations.
Intervention: Nine hundred micrograms of albuterol (10 puffs) was administered by a metered-dose inhaler into a spacer through the inspiratory arm of the ventilator circuit near to the patient, during 10 mechanically assisted breaths.
Measurements and Main Results: All children showed an increase in V′o<inf>2</inf> within 10 minutes (mean increase 48.6%). The increased V′o<inf>2</inf> was still elevated (42.3% above baseline) at 1 hour, but 3 hours after albuterol inhalation, the V′o<inf>2</inf> was back to baseline in all patients. Heart rate increased significantly at 10 minutes, 1 hour, and 2 hours after inhalation.
Conclusion: There is a large increase in V′o<inf>2</inf> after albuterol inhalation. This effect lasts up to 3 hours.
| Original language | English (US) |
|---|---|
| Pages (from-to) | e389-e392 |
| Journal | Pediatric Critical Care Medicine |
| Volume | 15 |
| Issue number | 9 |
| DOIs | |
| State | Published - Nov 10 2014 |
| Externally published | Yes |
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Keywords
- Albuterol inhalation
- Bronchodilator
- Children
- Mechanical ventilation
- Oxygen consumption
- Salbutamol
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Critical Care and Intensive Care Medicine
- Medicine(all)
Cite this
Increase in oxygen consumption after albuterol inhalation in ventilated infants and children. / Ross, Patrick A.; Newth, Christopher J L; Hugen, Cindy A C; Maher, John; Deakers, Timothy W.
In: Pediatric Critical Care Medicine, Vol. 15, No. 9, 10.11.2014, p. e389-e392.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increase in oxygen consumption after albuterol inhalation in ventilated infants and children
AU - Ross, Patrick A.
AU - Newth, Christopher J L
AU - Hugen, Cindy A C
AU - Maher, John
AU - Deakers, Timothy W.
PY - 2014/11/10
Y1 - 2014/11/10
N2 - Objective: To determine if inhaled albuterol (salbutamol) increases oxygen consumption (V′o2) in children and, if so, the duration of this effect.Design: Oxygen consumption was measured by indirect calorimetry using the Argon dilution technique with a respiratory mass spectrometer. After measurement of baseline values, albuterol was administered and subsequent measurements were performed at 10 minutes, 1 hour, 2 hours, 3 hours, and 4 hours.Setting: Multidisciplinary PICU in a university teaching hospital.Patients: Eleven intubated infants and children (five girls, six boys) with a mean age of 20 months (range, 1 mo to 8 yr) and a mean weight of 10.7 kg (range, 3.1-23 kg) who required therapeutic albuterol inhalations.Intervention: Nine hundred micrograms of albuterol (10 puffs) was administered by a metered-dose inhaler into a spacer through the inspiratory arm of the ventilator circuit near to the patient, during 10 mechanically assisted breaths.Measurements and Main Results: All children showed an increase in V′o2 within 10 minutes (mean increase 48.6%). The increased V′o2 was still elevated (42.3% above baseline) at 1 hour, but 3 hours after albuterol inhalation, the V′o2 was back to baseline in all patients. Heart rate increased significantly at 10 minutes, 1 hour, and 2 hours after inhalation.Conclusion: There is a large increase in V′o2 after albuterol inhalation. This effect lasts up to 3 hours.
AB - Objective: To determine if inhaled albuterol (salbutamol) increases oxygen consumption (V′o2) in children and, if so, the duration of this effect.Design: Oxygen consumption was measured by indirect calorimetry using the Argon dilution technique with a respiratory mass spectrometer. After measurement of baseline values, albuterol was administered and subsequent measurements were performed at 10 minutes, 1 hour, 2 hours, 3 hours, and 4 hours.Setting: Multidisciplinary PICU in a university teaching hospital.Patients: Eleven intubated infants and children (five girls, six boys) with a mean age of 20 months (range, 1 mo to 8 yr) and a mean weight of 10.7 kg (range, 3.1-23 kg) who required therapeutic albuterol inhalations.Intervention: Nine hundred micrograms of albuterol (10 puffs) was administered by a metered-dose inhaler into a spacer through the inspiratory arm of the ventilator circuit near to the patient, during 10 mechanically assisted breaths.Measurements and Main Results: All children showed an increase in V′o2 within 10 minutes (mean increase 48.6%). The increased V′o2 was still elevated (42.3% above baseline) at 1 hour, but 3 hours after albuterol inhalation, the V′o2 was back to baseline in all patients. Heart rate increased significantly at 10 minutes, 1 hour, and 2 hours after inhalation.Conclusion: There is a large increase in V′o2 after albuterol inhalation. This effect lasts up to 3 hours.
KW - Albuterol inhalation
KW - Bronchodilator
KW - Children
KW - Mechanical ventilation
KW - Oxygen consumption
KW - Salbutamol
UR - http://www.scopus.com/inward/record.url?scp=84928262061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928262061&partnerID=8YFLogxK
U2 - 10.1097/PCC.0000000000000279
DO - 10.1097/PCC.0000000000000279
M3 - Article
VL - 15
SP - e389-e392
JO - Pediatric Critical Care Medicine
JF - Pediatric Critical Care Medicine
SN - 1529-7535
IS - 9
ER -