Increased cmv igg antibody titer is associated with non-aids events among virologically suppressed hiv-positive persons

Aimee C. Hodowanec, Nell S. Lurain, Supriya Krishnan, Ronald J. Bosch, Alan L. Landay

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: Among HIV-positive individuals, increased levels of inflammation and immune activation persist even in the setting of effective antiretroviral therapy (ART) and are associated with greater rates of non-AIDS events. The etiology of this persistent inflammation is incompletely understood. Methods: Using a well-characterized cohort of 322 HIV-infected individuals on suppressive ART, we conducted a case-control study. Cytomegalovirus (CMV) immunoglobulin G (IgG) levels, plasma biomarkers, and T-cell phenotypes were measured/characterized from samples collected 1 year after ART initiation. Conditional logistic regression for matched case-control studies analyzed the associations of year 1 CMV-specific IgG level with the subsequent occurrence of any non-AIDS event. Correlations between continuous CMV IgG antibody levels and soluble and cellular markers were assessed. Results: We found that higher levels of CMV IgG were associated with increased risk of nonAIDS events (OR = 1.58 per IQR [95% CI: 1.12, 2.24], P = 0.01) and with elevated soluble and cellular markers of inflammation. Conclusions: The magnitude of the host immune response to CMV may play a role in the persistent inflammation and resultant morbid events observed in the HIV-positive population.

Original languageEnglish (US)
Pages (from-to)66-78
Number of pages13
JournalPathogens and Immunity
Issue number1
StatePublished - Feb 14 2019
Externally publishedYes


  • Cardiovascular events
  • Cytomegalovirus (CMV)
  • HIV
  • Immunity
  • Inflammation
  • Malignancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Molecular Biology
  • Microbiology (medical)
  • Infectious Diseases


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